Azmeraw Amare
NHMRC Emerging Leadership Fellow (C)
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Dr. Azmeraw Amare is a Clinical and Genetic Epidemiologist, interested in Precision medicine, pharmacogenomics, and translational medicine, and with particular expertise in using genetic and bioinformatic approaches to understand the biological basis of complex health conditions related to mental wellbeing, pharmacogenomics, cardiometabolic disorders and healthy ageing — in multiracial and multi-trait context.
He has a multidisciplinary educational background, with academic qualifications in clinical and genetic epidemiology (the University of Groningen in the Netherlands, MSc), public health research methodology (Université Libre de Bruxelles in Belgium, MPH), and Medicine (the University of Adelaide in Australia, PhD).
Dr Amare is the NHMRC Emerging Leadership Investigator (2022-2026), ARC Discovery Early Career Researcher Awardee (2022-2024, defered) and the US Brain Behaviour Research Foundation NARSAD Young Investigator (2019-2021) and leads the G-ENomics of mentAl well-Being and heaLthy age-ING (ENABLING) research group based at the Adelaide Medical School.
His research, which has been conducted in collaboration with scientists around the world, has sought to find an answer to fundamental questions about how genetics and the interaction between genetic and environmental factors regulate individuals’ risk to mental illness and response to pharmacological treatment. He has led several genetic association studies that identified novel genes underlying; (i) risk to mental illness (Amare AT, et al. Nature: Molecular Psychiatry, 2020), (ii) response to pharmacological treatment (Amare AT, et al. JAMA Psychiatry 2018; 75(1): 65-74.), (iii) variability in cardiovascular traits (Nolte IM, Munoz ML, Tragante V, Amare AT, et al. Nature Communications 2017; 8: 15805) and (iv) the overlapping effects of mental- and physical medical disorders (Amare AT, et al. Translational Psychiatry 2017; 7: e1007). The impact of his work has been recognised by prizes, scholarships and grant awards.
Dr Amare has an extraordinary publication track record, having authored or co-authored 93 articles (15 as a first/last author) and a book chapter, with 89% of them published in prestigious SCImago Q1 journals including in Nature, Nature Communications, Lancet, the New England Journal of Medicine, JAMA Psychiatry and Molecular Psychiatry, 54.4% listed in top 1%, 75% in top 10% (InCites). Dr Amare was selected by the Australian Review in consecutive years (2019 and 2020) as one of Australia’s top 40 Rising stars (best of 5 on Health and Medical Sciences list) among early-career researchers under 10 years.
Over 70,000 citations and H-index 54 (Google Scholar)
GENomics of mentAl wellBeing and heaLthy age-ING — ENABLING research group
Vision and Overall aim
Our DNA carries the basic instructions needed to reproduce, develop, survive and restore cellular damages. Unpacking DNA information and understanding the mechanisms of how the instruction in DNA is converted into proteins and interacts with the external environment is vital for a personalised approach to treatment, disease prevention and/or health promotion — to ultimately realise the century’s vision of precision medicine. Our group applies state-of-the-art data science techniques to understand the genetic and environmental determinants underlying the variability of human complex phenotypes including risk to diseases and response to treatment. Specifically, we are interested in studying the omics [genomics (DNA), epigenomes, transcriptomics (RNA), proteomics (Protein), metabolomics and microbiomes] of complex diseases and applying this knowledge to improve global health and address gaps in Culturally And Linguistically Diverse (CALD) people.
Leveraging genomic data obtained from international biobanks, our research applies advanced bioinformatic techniques to explore the “omics” of (a) risk and pharmacological treatment response to mental health disorders (depression, bipolar disorder, schizophrenia), (b) neurodegenerative disorders (Alzheimer's disease and other dementias), (c) ageing traits (frailty, longevity, cognition and intrinsic capacity) and (d)mechanism of genetic overlap across physical medical and mental health disorders.
Areas of research include
- Application of genomic sciences to Improve the Health of Culturally And Linguistically Diverse people — Diversity Genomics
- Pharmacogenomics in the treatment of mental illness
- The genomics of risk to mental illness — depression, bipolar disorder, schizophrenia
- Mechanism of genetic overlap across physical medical and mental health disorders
- The epidemiology of mental illness and effective clinical interventions
- Pharmacoepidemiology
- Genomics of healthy ageing traits — human intrinsic capacity
- Investigate the relationship of human intrinsic capacity with physical and mental health endpoints, including disability, morbidity, and mortality
“We have a place for Honours / PhD/ Masters / Mphil students who are interested in big data analytics — both genetic & clinical data using python or R programming languages. Students with a quantitative science background such as bioinformatics, computer science, mathematics, physics, engineering, Epidemiology/Biostatistics etc would be appropriate.”
Lead researcher: Dr Azmeraw Amare
Research team
• A/Prof K Oliver Schubert
• A/Prof Scott Clark
• Dr Natalie Mills
• Dr Liliana Ciobanu
• Dr Micah Cearns
Partnerships
• Prof Bernhard Baune – University of Münster, Germany
• Prof Renuka Visvanathan –University of Adelaide, Australia
• Prof Harold Snieder – the University of Groningen, the Netherlands
• A/Prof Sarah Cohen-Woods – Flinders University, Australia
• A/Prof Yi-Hsiang Hsu – Harvard Medical school, the United States of America
• Dr Fasil Tekola Ayele – National Institute of Health (NIH), the United States of America
Grants, Scholarships and Awards
- 2021-2026 NHMRC Investigator Grant Emerging Leadership. Role: CIA (AUD 650,740).
- 2022-2027 NHMRC-EU Collaborative Research - Horizon 2020 Programme. Role: CID (AUD 500,000).
- 2022-2027 European Commission - Horizon 2020 Programme Collaborative Research. Role: AI (EURO 11 million). PSYCH-STRATA - A Stratified Treatment Algorithm in Psychiatry: A program on stratified pharmacogenomics in severe mental illness
- 2022-2027 MRFF 2021 Genomics Health Futures Mission: The Australian Genetic Diversity Database: towards a more equitable future for genomic medicine in Australia. Role: CI (AUD 10 million).
- 2022 University of Adelaide international travel Award, AUD 3,000.
- Early Career Travel Award by the International Society of Psychiatric Genetics (ISPG) to attend the World Congress of Psychiatric Genetics (WCPG) in Florence (Italy)
- 2021 ARC Discovery Early Career Researcher Award (DECRA). Role: CIA (AUD 365,000, defer).
- 2021 The University of Adelaide, Faculty Emerging Leaders Development Award. Role: CIA (AUD 40,000).
- 2019-2021 Brain and Behaviour Research Foundation NARSAD young investigator grant. Role: CIA (AUD 102,000).
- 2019 & 2020 (two consecutive years) Recognised as one of Australia’s top 40 Rising stars (best of 5 in Health & Medical Sciences list) among all researchers under 10 years into their research career by The Australian newspaper research Review. https://specialreports.theaustralian.com.au/1540291/27/
- 2018 University of Adelaide Doctoral Research Medal for Outstanding research at PhD level and Dean’s Commendation for Doctoral Thesis Excellence.
- 2017 University of Adelaide international research travel grant (AUD 3000).
- 2017 World Psychiatric Association Young Scientists Fellowship by the World Psychiatric Association [Germany].
- 2015-2018 Adelaide Scholarship International (est.AUD 220,000) [Australia].
- 2014 University of Washington summer Scholarship to attend the 19th summer institute in statistical genetics courses [USA].
- 2012-2014 University of Groningen International Scholarship for Postgraduate Study [Netherlands]
- 2011-2012 Government of Belgium University Commission for Development (CIUF-CUD) Postgraduate Scholarship [Belgium].
Selected Publications
- Amare AT, Schubert KO, Hou L, Clark SR, Papiol S, Heilbronner U et al. Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study. JAMA Psychiatry 2018; 75(1): 65-74.
- Amare AT, Ahmad Vaez, Yi-Hsiang Hsu, Nese Direk, Zoha Kamali, David M. Howard, Andrew M. McIntosh, Henning Tiemeier, Ute Bültmann, Harold Snieder, Catharina A. Hartman. Bivariate genome-wide association analyses of a broad depression phenotype combined with major depression, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression. Nature: Molecular Psychiatry 2020, 25(7), 1420-1429.
- Amare AT, Schubert KO, Klingler-Hoffmann M, Cohen-Woods S, Baune BT. The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome-wide and candidate gene studies. Translational Psychiatry 2017; 7: e1007.
- Amare AT, Schubert KO, Baune BT. Pharmacogenomics in the treatment of mood disorders: Strategies and Opportunities for personalized psychiatry. The EPMA journal 2017; 8(3): 211-227.
- Amare AT, Schubert KOT, Schulze TG, Baune B. Association of Polygenic Score for Major Depression with Response to Lithium in Patients with Bipolar Disorder. Nature: Molecular Psychiatry, 2020.
- Amare AT, Schubert KO, Tekola-Ayele F, Hsu YH, Sangkuhl K, Jenkins G et al. Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder. Frontiers in Psychiatry 2018; 9: 65.
- Amare AT, Schubert KO, Tekola-Ayele F, Hsu YH, Sangkuhl K, Jenkins G et al. The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression. Journal of neural transmission 2019.
- Tekola-Ayele F, Workalemahu T, Amare AT. High burden of birthweight-lowering genetic variants in Africans and Asians. BMC medicine 2018; 16(1): 70.
- Stacey D, Schubert KO, Clark SR, Amare AT, Milanesi E, Maj C et al. A gene co-expression module implicating the mitochondrial electron transport chain is associated with long-term response to lithium treatment in bipolar affective disorder. Transl Psychiatry 2018; 8(1): 183.
- Opel N, Amare AT, Redlich R, Repple J, Kaehler C, Grotegerd D et al. Cortical surface area alterations shaped by the genetic load for neuroticism. Molecular Psychiatry 2018.
- Nolte IM, Munoz ML, Tragante V, Amare AT, Jansen R, Vaez A et al. Genetic loci associated with heart rate variability and their effects on cardiac disease risk. Nature Communications 2017; 8: 15805.
- Haljas K, Amare AT, Alizadeh BZ, Hsu YH, Mosley T, Newman A et al. Bivariate Genome-Wide Association Study of Depressive Symptoms With Type 2 Diabetes and Quantitative Glycemic Traits. Psychosomatic medicine 2018; 80(3): 242-251.
- Ni G, Amare AT, Zhou X, Mills N, Gratten J, Lee SH. The genetic relationship between female reproductive traits and six psychiatric disorders. Sci Rep 2019; 9(1): 12041.
- Direk N, Williams S, Smith JA, Ripke S, Air T, Amare AT, et al. An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype. Biological Psychiatry 2017; 82(5): 322-329.
- Ciobanu LG, Ferrari AJ, Erskine HE, Santomauro DF, Charlson FJ, Leung J Amare AT et al. The prevalence and burden of mental and substance use disorders in Australia: Findings from the Global Burden of Disease Study 2015. The Australian and New Zealand journal of psychiatry 2018; 52(5): 483-490.
- Amare AT, Caughey GE, Whitehead C, Lang CE, Bray SCE, Corlis M, Visvanathan R, Wesselingh S, Inacio MC. The prevalence, trends and determinants of mental health disorders in older Australians living in permanent residential aged care: Implications for policy and quality of aged care services. The Australian & New Zealand Journal of Psychiatry 2020; 54(12): 1200-1211.
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Appointments
Date Position Institution name 2023 - ongoing Senior Researcher Level C University of Adelaide 2020 - ongoing Research Fellow University of Adelaide 2018 - 2020 Postdoc South Australian Health and Medical Research Institute 2018 - 2022 Lecturer Level B University of Adelaide 2015 - 2018 PhD University of Adelaide -
Awards and Achievements
Date Type Title Institution Name Country Amount 2019 Award 2018 Doctoral Research Medal for Outstanding research at PhD level University of Adelaide Australia Gold Medal 2018 Research Award Dean's Commendation for Doctoral Thesis Excellence University of Adelaide Australia - 2017 Fellowship 2017 World congress of psychiatry Young Fellowship Programme World Psychiatric Association Germany - 2015 Scholarship Adelaide Scholarship International (ASI) University of Adelaide Australia - 2014 Scholarship 19th summer institute in statistical genetics courses in Seattle University of Washington United States - 2012 Scholarship CPE-SHARE research institute, University Medical center Groningen University of Groningen Netherlands - 2011 Scholarship CIUF-CUD Scholarship for postgraduate Study Belgium University Commission for Development (CIUF-CUD) Belgium - 2006 Award Top student and gold medal among 2006 graduates in the faculty of public health Hawassa University Ethiopia Gold Medal -
Education
Date Institution name Country Title 2015 - 2018 University of Adelaide Australia PhD in Medicine 2014 - 2014 University of Groningen, Groningen Netherlands Master of Science in Clinical and Psychosocial Epidemiology (Research master) 2011 - 2012 Université Libre de Bruxelles, Brussels Belgium Master in research methodology -
Certifications
Date Title Institution name Country 2014 19th Summer Institute in Statistical Genetics University of Washington United States -
Research Interests
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Journals
Year Citation 2024 Ou, A. H., Rosenthal, S. B., Adli, M., Akiyama, K., Akula, N., Alda, M., . . . Schalling, M. (2024). Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study. Translational Psychiatry, 14(1), 109.
2023 Amare, A. T., Thalamuthu, A., Schubert, K. O., Fullerton, J. M., Ahmed, M., Hartmann, S., . . . Baune, B. T. (2023). Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder. Molecular Psychiatry, 1-11.
Scopus3 WoS2 Europe PMC72023 GBD 2019 Australia Collaborators. (2023). The burden and trend of diseases and their risk factors in Australia, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet Public Health, 8(8), e585-e599.
Scopus8 WoS2 Europe PMC32023 Global Burden of Disease 2021 Health Financing Collaborator Network., Baune, B., Sharew, N., Amare, A., Olagunju, A., Opio, J. N., & Noubiap Nzeale, J. J. (2023). Global investments in pandemic preparedness and COVID-19: development assistance and domestic spending on health between 1990 and 2026.. The Lancet. Global health, 11(3), e385-e413.
Scopus83 WoS37 Europe PMC252023 Amare, A., Thalamuthu, A., Schubert, K. O., Fullerton, J., Ahmed, M., Hartmann, S., . . . Baune, B. (2023). Association of Polygenic Score and the involvement of Cholinergic and Glutamatergic Pathways with Lithium Treatment Response in Patients with Bipolar Disorder. Res Sq.
2023 Herrera-Rivero, M., Gutiérrez-Fragoso, K., Thalamuthu, A., Amare, A., Adli, M., Akiyama, K., . . . Baune, B. (2023). Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder. Res Sq.
2023 Kelsoe, J., Ou, A., Rosenthal, S., Adli, M., Akiyama, K., Akula, N., . . . Zompo, M. D. (2023). Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study.. Res Sq.
2023 Herrera-Rivero, M., Adli, M., Akiyama, K., Akula, N., Amare, A. T., Ardau, R., . . . Baune, B. T. (2023). Exploring the genetics of lithium response in bipolar disorders.. Res Sq.
2022 Reiner, R. C., Hay, S. I., Bhandari, D., & LBD Triple Burden Collaborators. (2022). The overlapping burden of the three leading causes of disability and death in sub-Saharan African children. Nature Communications, 13(1), 1-14.
Scopus3 Europe PMC12022 Cearns, M., Amare, A. T., Schubert, K. O., Thalamuthu, A., Frank, J., Streit, F., . . . Stamm, T. (2022). Erratum: Using polygenic scores and clinical data for bipolar disorder patient stratification and lithium response prediction: Machine learning approach (The British Journal of Psychiatry (2022) (1–10) DOI: 10.1192/bjp.2022.28). British Journal of Psychiatry, 221(2), 494.
Europe PMC12022 Schubert, K. O., Thalamuthu, A., Amare, A. T., Frank, J., Streit, F., Adl, M., . . . Baune, B. T. (2022). Correction: Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients.. Translational psychiatry, 12(1), 278.
WoS12022 Ciobanu, L. G., Stankov, L., Schubert, K. O., Amare, A. T., Jawahar, M. C., Lawrence-Wood, E., . . . Aidman, E. (2022). General intelligence and executive functioning are overlapping but separable at genetic and molecular pathway levels: An analytical review of existing GWAS findings. PLOS ONE, 17(10), e0272368.
Scopus1 Europe PMC12022 Repple, J., König, A., de Lange, S. C., Opel, N., Redlich, R., Meinert, S., . . . van den Heuvel, M. P. (2022). Association between genetic risk for type 2 diabetes and structural brain connectivity in major depressive disorder. Biol Psychiatry Cogn Neurosci Neuroimaging, 7(3), 333-340.
Scopus6 WoS4 Europe PMC12022 Taylor, D., Amare, A. T., Edwards, S., Inacio, M., & Visvanathan, R. (2022). A vulnerable residential environment is associated with higher risk of mortality and early transition to permanent residential aged care for community dwelling older South Australians. Age and Ageing, 51(3), afac029-1-afac029-9.
Scopus5 WoS3 Europe PMC22022 Cearns, M., Amare, A. T., Schubert, K. O., Thalamuthu, A., Frank, J., Streit, F., . . . Baune, B. T. (2022). Using polygenic scores and clinical data for bipolar disorder patient stratification and lithium response prediction: machine learning approach. The British Journal of Psychiatry, 220(4), 219-228.
Scopus11 WoS8 Europe PMC42021 Visvanathan, R., Amare, A. T., Wesselingh, S., & Inacio, M. C. (2021). General practitioner conduct of clinical services representing comprehensive geriatric assessment is associated with lower risk of mortality in older Australians receiving home care packages. Age and Ageing, 50(4), 1243-1251.
Scopus4 WoS32021 Le Clerc, S., Lombardi, L., Baune, B. T., Amare, A. T., Schubert, K. O., Hou, L., . . . Tamouza, R. (2021). HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders. Scientific Reports, 11(1), 17823-1-17823-12.
Scopus7 WoS6 Europe PMC72021 Coombes, B. J., Millischer, V., Batzler, A., Larrabee, B., Hou, L., Papiol, S., . . . Biernacka, J. M. (2021). Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study. Complex Psychiatry, 7(3-4), 80-89.
Scopus5 Europe PMC22021 Ward, J. L., Azzopardi, P. S., Francis, K. L., Santelli, J. S., Skirbekk, V., Sawyer, S. M., . . . Viner, R. M. (2021). Global, regional, and national mortality among young people aged 10-24 years, 1950-2019: a systematic analysis for the Global Burden of Disease Study 2019. LANCET, 398(10311), 1593-1618.
Scopus82 WoS26 Europe PMC532021 Schubert, K. O., Thalamuthu, A., Amare, A. T., Frank, J., Streit, F., Adl, M., . . . Baune, B. T. (2021). Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients. Translational Psychiatry, 11(1), 100-108.
Scopus19 WoS15 Europe PMC122021 Visvanathan, R., Amare, A. T., Lang, C., Khadka, J., Yu, S., Beilby, J., . . . Inacio, M. C. (2021). Utilisation of general practice health assessments around an aged care assessment is associated with lower mortality risk in older Australians. Age and Ageing, 50(1), 120-126.
Scopus9 WoS8 Europe PMC12021 Amare, A. T., Schubert, K. O., Hou, L., Clark, S. R., Papiol, S., Cearns, M., . . . Binder, E. B. (2021). Association of polygenic score for major depression with response to lithium in patients with bipolar disorder. Molecular Psychiatry, 26(6), 2457-2470.
Scopus35 WoS39 Europe PMC262020 Amare, A., Bhandari, D., Gill, T., Hariyani, N., Noubiap Nzeale, J., & LBD Double Burden of Malnutrition Collaborators. (2020). Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017. Nature Medicine, 26(5), 750-759.
Scopus47 WoS43 Europe PMC312020 Reiner, R. C., Wiens, K. E., Deshpande, A., Baumann, M. M., Lindstedt, P. A., Blacker, B. F., . . . Bekele, Y. A. (2020). Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000-17: Analysis for the Global Burden of Disease Study 2017. The Lancet, 395(10239), 1779-1801.
Scopus64 WoS52 Europe PMC512020 Reiner, R. C., Wiens, K. E., Deshpande, A., Baumann, M. M., Lindstedt, P. A., Blacker, B. F., . . . Bekele, Y. A. (2020). Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000-17: Analysis for the Global Burden of Disease Study 2017. The Lancet, 395(10239), 1779-1801.
Scopus64 WoS52 Europe PMC512020 Scott, J., Etain, B., Manchia, M., Brichant-Petitjean, C., Geffory, P., Schulze, T., . . . Schubert, K. (2020). An examination of the quality and performance of the Alda scale for classifying lithium response phenotypes. Bipolar Disorders, 22(3), 255-265.
Scopus23 WoS21 Europe PMC122020 Inacio, M. C., Amare, A. T., Whitehead, C., Bray, S. C. E., Corlis, M., Visvanathan, R., & Wesselingh, S. (2020). Factors associated with accessing aged care services in Australia after approval for services: Findings from the historical cohort of the Registry of Senior Australians.. Australasian journal on ageing, 39(3), 382-392.
Scopus8 WoS8 Europe PMC72020 Amare, A. T., Vaez, A., Hsu, Y. H., Direk, N., Kamali, Z., Howard, D. M., . . . Hartman, C. A. (2020). Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression. Molecular Psychiatry, 25(7), 1420-1429.
Scopus52 WoS44 Europe PMC322020 Inacio, M. C., Visvanathan, R., Lang, C. E., Amare, A., Harrison, S. L., & Wesselingh, S. (2020). Pain in older Australians seeking aged care services: Findings from the Registry of Older South Australians (ROSA). Journal of the American Medical Directors Association, 21(1), 132-133.
Scopus2 WoS2 Europe PMC12020 Kinyoki, D., Ross, J., Lazzar-Atwood, A., Munro, S., Schaeffer, L., Abbasalizad-Farhangi, M., . . . Awasthi, A. (2020). Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017 (Nature Medicine, (2020), 26, 5, (750-759), 10.1038/s41591-020-0807-6). Nature Medicine, 26(8), 1308.
2020 Reiner, R., Wiens, K., Deshpande, A., Baumann, M., Lindstedt, P., Blacker, B., . . . Bell, M. (2020). Department of Error: Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Study 2017 (The Lancet (2020) 395(10239) (1779–1801), (S0140673620301148), (10.1016/S0140-6736(20)30114-8)). The Lancet, 395(10239), 1762.
Scopus12020 Amare, A. T., Caughey, G. E., Whitehead, C., Lang, C. E., Bray, S. C. E., Corlis, M., . . . Inacio, M. C. (2020). The prevalence, trends and determinants of mental health disorders in older Australians living in permanent residential aged care: implications for policy and quality of aged care services. Australian and New Zealand Journal of Psychiatry, 54(12), 1200-1211.
Scopus25 WoS20 Europe PMC102020 Khadka, J., Visvanathan, R., Theou, O., Moldovan, M., Amare, A. T., Lang, C., . . . Inacio, M. C. (2020). Development and validation of a frailty index based on Australian Aged Care Assessment Program data. Medical Journal of Australia, 213(7), 321-326.
Scopus19 WoS19 Europe PMC112020 Reiner, R., & Hay, S. (2020). Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000-17: analysis for the Global Burden of Disease Study 2017 (vol 395, pg 1779, 2020). LANCET, 395(10239), 1762.
WoS12020 GBD 2019 Risk Factors Collaborators., Bhandari, D., Baune, B., Lalloo, R., Noubiap Nzeale,, J. J., Ciobanu, L., & Lassi, Z. (2020). Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet, 396(10258), 1223-1249.
Scopus3732 WoS3510 Europe PMC20752020 GBD 2019 Diseases and Injuries Collaborators., Baune, B., Bhandari, D., Ciobanu, L., Lalloo, R., Lassi, Z., & Noubiap Nzeale, J. (2020). Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet, 396(10258), 1204-1222.
Scopus7161 WoS2780 Europe PMC44382020 Murray, C. J. L., Abbafati, C., Abbas, K. M., Abbasi, M., Abbasi-Kangevari, M., Abd-Allah, F., . . . Badiye, A. D. (2020). Five insights from the Global Burden of Disease Study 2019. The Lancet, 396(10258), 1135-1159.
Scopus327 WoS303 Europe PMC1762020 Wang, H., Abbas, K. M., Abbasifard, M., Abbasi-Kangevari, M., Abbastabar, H., Abd-Allah, F., . . . Noubiap Nzeale, J. (2020). Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019. The Lancet, 396(10258), 1160-1203.
Scopus842 WoS454 Europe PMC5502020 Bousman, C. A., Bengesser, S. A., Aitchison, K. J., Amare, A. T., Aschauer, H., Baune, B. T., . . . Müller, D. J. (2020). Review and Consensus on Pharmacogenomic Testing in Psychiatry.. Pharmacopsychiatry, 54(1), 5-17.
Scopus87 WoS76 Europe PMC492019 Stanaway, J. D., Afshin, A., Gakidou, E., Lim, S. S., Abate, D., Abate, K. H., . . . Azzopardi, P. S. (2019). Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1923–1994), (S0140673618322256), (10.1016/S0140-6736(18)32225-6)). The Lancet, 393(10190), e44.
Scopus4 Europe PMC12019 Tekola-Ayele, F., Lee, A., Workalemahu, T., Zhang, W., Shrestha, D., Amare, A. T., & Ouidir, M. (2019). Genetic overlap between birthweight and adult cardiometabolic diseases has implications for genomic medicine. Scientific Reports, 9(1), 8 pages.
Scopus5 WoS5 Europe PMC42019 Stanaway, J. D., Reiner, R. C., Blacker, B. F., Goldberg, E. M., Khalil, I. A., Troeger, C. E., . . . Hay, S. I. (2019). The global burden of typhoid and paratyphoid fevers: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet Infectious Diseases, 19(4), 369-381.
Scopus394 WoS311 Europe PMC2842019 Deribew, A., Biadgilign, S., Deribe, K., Dejene, T., Tessema, G. A., Melaku, Y. A., . . . Wang, H. (2019). The Burden of HIV/AIDS in Ethiopia from 1990 to 2016: Evidence from the Global Burden of Diseases 2016 Study. Ethiopian journal of health sciences, 29(1), 859-868.
Scopus31 WoS30 Europe PMC282019 Orpana, H., Marczak, L., Arora, M., Abbasi, N., Abdulkader, R., Abebe, Z., . . . Jha, R. (2019). Global, regional, and national burden of suicide mortality 1990 to 2016: Systematic analysis for the Global Burden of Disease Study 2016. BMJ (Online), 364(1), 11 pages.
Scopus144 WoS1918 Europe PMC2882019 Leehr, E. J., Opel, N., Werner, J., Redlich, R., Repple, J., Grotegerd, D., . . . Dannlowski, U. (2019). Evidence for a sex-specific contribution of polygenic load for anorexia nervosa to body weight and prefrontal brain structure in nonclinical individuals. Neuropsychopharmacology, 44(13), 2212-2219.
Scopus1 WoS12019 Ni, G., Amare, A. T., Zhou, X., Mills, N., Gratten, J., & Lee, S. H. (2019). The genetic relationship between female reproductive traits and six psychiatric disorders. Scientific Reports, 9(1), 12041-1-12041-12.
Scopus15 WoS11 Europe PMC92019 Visvanathan, R., Amare, A. T., Wesselingh, S., Hearn, R., McKechnie, S., Mussared, J., & Inacio, M. C. (2019). Prolonged wait time prior to entry to home care packages increases the risk of mortality and transition to permanent residential aged care services: findings from the Registry of Older South Australians (ROSA). Journal of Nutrition, Health and Aging, 23(3), 271-280.
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WoS274 Europe PMC1572015 GBD 2013 DALYs Collaborators., HALE Collaborators., Murray, C., Barber, R., Foreman, K., Ozgoren, A., . . . Başara, B. (2015). Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition. The Lancet, 386(10009), 2145-2191.
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Scopus2104 WoS1850 Europe PMC12142015 Lalloo, R., & GBD 2013 Mortality and Causes of Death Collaborators. (2015). Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet, 385(9963), 117-171.
Scopus5878 WoS4745 Europe PMC34612015 Global Burden of Disease Cancer Collaboration. (2015). The global burden of cancer 2013. JAMA oncology, 1(4), 505-527.
Scopus2360 WoS2073 Europe PMC14342014 Wang, H., Liddell, C., Coates, M., Mooney, M., Levitz, C., Schumacher, A., . . . Hay, S. (2014). Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet, 384(9947), 957-979.
Scopus573 WoS442 Europe PMC3992014 Kassebaum, N., Bertozzi-Villa, A., Coggeshall, M., Shackelford, K., Steiner, C., Heuton, K., . . . Lozano, R. (2014). Global, regional, and national levels and causes of maternal mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet, 384(9947), 980-1004.
Scopus1085 WoS583 Europe PMC7102014 Murray, C., Ortblad, K., Guinovart, C., Lim, S., Wolock, T., Roberts, D., . . . Dayama, A. (2014). Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet, 384(9947), 1005-1070.
Scopus728 WoS615 Europe PMC5302014 Kassebaum, N. J., Bertozzi-Villa, A., & Coggeshall, M. S. (2014). Global, regional, and national levels and causes of maternal mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013 (vol 384, pg 980, 2014). LANCET, 384(9947), 956.
WoS3192011 Tayelgn, A., Zegeye, D., & Kebede, Y. (2011). Mothers' satisfaction with referral hospital delivery service in Amhara Region, Ethiopia. BMC Pregnancy and Childbirth, 11(1), 78.
Scopus73 WoS68 Europe PMC66 -
Book Chapters
Year Citation 2016 Amare, A., Schubert., & Baune. (2016). Genetic Overlap Between Depression and Cardiometabolic Disorders. In Baune, & Tully (Eds.), Cardiovascular Diseases and Depression Treatment and Prevention in Psychocardiology (pp. 235-255). Switzerland: Springer.
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Conference Papers
Year Citation 2017 Baune, B., Amare, A., Schubert, K. O., & Biernacka, J. (2017). POLYGENIC SCORE FOR CARDIOMETABOLIC AND PSYCHIATRIC PHENOTYPES PREDICT RESPONSE TO TREATMENT WITH SELECTIVE SEROTONIN REUPTAKE INHIBITORS IN MAJOR DEPRESSIVE DISORDER. In EUROPEAN NEUROPSYCHOPHARMACOLOGY Vol. 27 (pp. S512-S513). Jerusalem, ISRAEL: ELSEVIER SCIENCE BV.
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Conference Items
Year Citation 2022 Amare, A., Thalamuthu, A., Schubert, K. O., McMahon, F. J., Schulze, T. G., Clark, S., & Baune, B. (2022). POLYGENIC SCORE IDENTIFIES BIPOLAR PATIENTS ULTRA-RESPONSIVE TO LITHIUM TREATMENT. Poster session presented at the meeting of European Neuropsychopharmacology. Florence, Italy: Elsevier BV.
2021 Ciobanu, L., Stankov, L., Heathcote, A., Clark, S., Breen, J., Rogasch, N., . . . Aidman, E. (2021). Mapping the genetic architectures of cognitive functioning. Poster session presented at the meeting of GeneMappers 2021. Virtual. 2020 Ciobanu, L., Schubert, O., Amare, A., Jawahar, C., Lawrence-Woods, E., Mills, N., . . . Aidman, E. (2020). P9. MAPPING THE GENETIC ARCHITECTURES OF COGNITIVE FITNESS: CAN GWAS DATA DIFFERENTIATE EXECUTIVE FUNCTIONING FROM GENERAL COGNITIVE ABILITY?. Poster session presented at the meeting of Nature Neurogenetics. New York. 2020 Ciobanu, L., Schubert, K. O., Amare, A., Jawahar, C., Mills, N., Knight, M., . . . Aidman, E. (2020). Genetic Pathways of Cognitive Performance are Overlapping but Distinct for General Intelligence and Executive Functioning Tasks. Poster session presented at the meeting of 2020 Virtual World Congress of Psychiatric Genetics. Virtual. 2020 Ciobanu, L., Schubert, K. O., Amare, A., Jawahar, C., Lawrence-Woods, E., Knight, M., . . . Aidman, E. (2020). Genetic Markers of Cognitive Fitness. Poster session presented at the meeting of Defence Human Sciences Symposium 2020. online. 2020 Cearns, M., Amare, A., Clark, S. R., & Baune, B. (2020). Meta-polygenic stratification of bipolar patients increases the accuracy of lithium response prediction using clinical data. Poster session presented at the meeting of 2020 Virtual World Congress of Psychiatric Genetics. Virtual. 2017 Haljas, K., Lahti, J., Amare, A. T., Alizadeh, B. Z., Snieder, H., Eriksson, J., & Raikkonen, K. (2017). A BIVARIATE GENOME-WIDE ASSOCIATION STUDY (GWAS) OF DEPRESSIVE SYMPTOMS AND FASTING GLUCOSE/INSULIN. Poster session presented at the meeting of EUROPEAN NEUROPSYCHOPHARMACOLOGY. Toronto, CANADA: ELSEVIER SCIENCE BV. 2015 Amare, A. T., Nigatu, Y. T., Hsu, Y. -H., Lahti, J., Alizadeh, B. Z., & Snieder, H. (2015). A bivariate Genome Wide Association Study (GWAS) of depressive symptoms and lipid levels has identified pleiotropic gene loci. Poster session presented at the meeting of INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE. Montreal, CANADA: PERGAMON-ELSEVIER SCIENCE LTD.
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Preprint
Year Citation 2024 Beyene, M. B., Visvanathan, R., Ahmed, M., Benyamin, B., Beard, J., & Amare, A. (2024). Development and Validation of an Intrinsic Capacity Score in the UK Biobank Study.
2024 Ahmed, M., Mulugeta, A., Okewole, N., Clark, S., Iyegbe, C., & Amare, A. (2024). Pharmacogenomic diversity in psychiatry: Challenges and Opportunities in Africa.
- 2021-2026 NHMRC Investigator Grant Emerging Leadership. Role: CIA (AUD 650,740).
- 2022-2027 NHMRC-EU Collaborative Research - Horizon 2020 Programme. Role: CID (AUD 500,000).
- 2022-2027 European Commission - Horizon 2020 Programme Collaborative Research. Role: AI (EURO 11 million). PSYCH-STRATA - A Stratified Treatment Algorithm in Psychiatry: A program on stratified pharmacogenomics in severe mental illness
- 2022-2027 MRFF 2021 Genomics Health Futures Mission: The Australian Genetic Diversity Database: towards a more equitable future for genomic medicine in Australia. Role: CI (AUD 10 million).
- 2022 University of Adelaide international travel Award, AUD 3,000.
- Early Career Travel Award by the International Society of Psychiatric Genetics (ISPG) to attend the World Congress of Psychiatric Genetics (WCPG) in Florence (Italy)
- 2021 ARC Discovery Early Career Researcher Award (DECRA). Role: CIA (AUD 365,000, defer).
- 2021 The University of Adelaide, Faculty Emerging Leaders Development Award. Role: CIA (AUD 40,000).
- 2019-2021 Brain and Behaviour Research Foundation NARSAD young investigator grant. Role: CIA (AUD 102,000).
- 2019 & 2020 (two consecutive years) Recognised as one of Australia’s top 40 Rising stars (best of 5 in Health & Medical Sciences list) among all researchers under 10 years into their research career by The Australian newspaper research Review. https://specialreports.theaustralian.com.au/1540291/27/
- 2018 University of Adelaide Doctoral Research Medal for Outstanding research at PhD level and Dean’s Commendation for Doctoral Thesis Excellence.
- 2017 University of Adelaide international research travel grant (AUD 3000).
- 2017 World Psychiatric Association Young Scientists Fellowship by the World Psychiatric Association [Germany].
- 2015-2018 Adelaide Scholarship International (est.AUD 220,000) [Australia].
- 2014 University of Washington summer Scholarship to attend the 19th summer institute in statistical genetics courses [USA].
- 2012-2014 University of Groningen International Scholarship for Postgraduate Study [Netherlands]
- 2011-2012 Government of Belgium University Commission for Development (CIUF-CUD) Postgraduate Scholarship [Belgium].
Course coordinator and lecturer for the course "Genetic Epidemiology"
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2022 Principal Supervisor An Investigation into the Genetic Basis of Human Intrinsic Reserve Doctor of Philosophy Doctorate Full Time Mr Melkamu Bedimo Beyene 2022 Principal Supervisor Developing Genetic Testing Tools for Optimising Pharmacotherapy and Enabling a Precision Mental Health Care Doctor of Philosophy Doctorate Full Time Mr Nigussie Tadesse Sharew
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