2024 |
Lau, A. A., Trim, P. J., King, B. M., Hassiotis, S., Hung, Y. H., Bush, A. I., . . . Hemsley, K. M. (2024). Filipin complex-reactive brain lesions: A cautionary tale. Neuropathology and Applied Neurobiology, 50(1), 8 pages. DOI |
2023 |
Tan, S. L., Hewson, L. J., Mustaffar, N. F., He, Q. Q., Wimmer, N., Trim, P. J., . . . Lau, A. A. (2023). Substrate reduction therapy in a<i>Drosophila melanogaster</i>model of Sanfilippo syndrome. DOI |
2022 |
Whyte, L. S., Fourrier, C., Hassiotis, S., Lau, A. A., Trim, P. J., Hein, L. K., . . . Sargeant, T. J. (2022). Lysosomal gene Hexb displays haploinsufficiency in a knock-in mouse model of Alzheimer's disease. IBRO Neuroscience Reports, 12, 131-141. DOI Scopus8 WoS6 Europe PMC6 |
2021 |
Jolly, R. D., Hunter, S. A., Alley, M. R., King, B. M., Lau, A. A., Trim, P. J., . . . Hemsley, K. M. (2021). Mucopolysaccharidosis II (MPS II) in a free-living kaka (nestor meridionalis) in New Zealand. Journal of Wildlife Diseases, 57(4), 884-890. DOI Scopus2 WoS1 |
2020 |
Hocquemiller, M., Hemsley, K. M., Douglass, M. L., Tamang, S. J., Neumann, D., King, B. M., . . . Laufer, R. (2020). AAVrh10 Vector Corrects Disease Pathology in MPS IIIA Mice and Achieves Widespread Distribution of SGSH in Large Animal Brains. Molecular Therapy Methods and Clinical Development, 17, 174-187. DOI Scopus22 WoS15 Europe PMC16 |
2020 |
Whyte, L. S., Hassiotis, S., Hattersley, K. J., Hemsley, K. M., Hopwood, J. J., Lau, A. A., & Sargeant, T. J. (2020). Lysosomal Dysregulation in the Murine App<sup>NL-G-F/NL-G-F</sup> Model of Alzheimer's Disease. Neuroscience, 429, 143-155. DOI Scopus10 WoS10 Europe PMC7 |
2019 |
Lau, A. A., Hopwood, J. J., & Hemsley, K. M. (2019). Canine adenoviral vector-mediated gene transfer to the guinea pig brain. Gene Reports, 16, 100432-1-100432-5. DOI Scopus1 WoS1 |
2019 |
He, Q. Q., Trim, P. J., Lau, A. A., King, B. M., Hopwood, J. J., Hemsley, K. M., . . . Ferro, V. (2019). Synthetic disaccharide standards enable quantitative analysis of stored heparan sulfate in MPS IIIA murine brain regions. ACS Chemical Neuroscience, 10(8), 3847-3858. DOI Scopus9 WoS7 Europe PMC5 |
2018 |
Lau, A. A., Tamang, S. J., & Hemsley, K. M. (2018). MPS-IIIA mice acquire autistic behaviours with age. Journal of Inherited Metabolic Disease, 41(4), 669-677. DOI Scopus10 WoS8 Europe PMC8 |
2017 |
Lau, A. A., & Hemsley, K. M. (2017). Adeno-associated viral gene therapy for mucopolysaccharidoses exhibiting neurodegeneration. Journal of Molecular Medicine, 95(10), 1043-1052. DOI Scopus7 WoS5 Europe PMC4 |
2017 |
Hemsley, K., & Lau, A. (2017). Intracerebral gene therapy for mucopolysaccharidosis type IIIB syndrome. The Lancet Neurology, 16(9), 681-682. DOI |
2017 |
Whyte, L. S., Lau, A. A., Hemsley, K. M., Hopwood, J. J., & Sargeant, T. J. (2017). Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?. Journal of Neurochemistry, 140(5), 703-717. DOI Scopus97 WoS95 Europe PMC72 |
2017 |
Lau, A. A., King, B. M., Thorsen, C. L., Hassiotis, S., Beard, H., Trim, P. J., . . . Hemsley, K. M. (2017). A novel conditional Sgsh knockout mouse model recapitulates phenotypic and neuropathic deficits of Sanfilippo syndrome. Journal of Inherited Metabolic Disease, 40(5), 715-724. DOI Scopus9 WoS8 Europe PMC5 |
2017 |
Whyte, L. S., Hemsley, K. M., Lau, A. A., Hassiotis, S., Saito, T., Hopwood, J. J., & Sargeant, T. J. (2017). Reduction in open field activity in the absence of memory deficits in the AppNL-G-F knock-in mouse model of Alzheimer’s disease. Behavioural Brain Research, 336, 177-181. DOI Scopus47 WoS44 Europe PMC31 |
2016 |
Winner, L. K., Beard, H., Hassiotis, S., Lau, A. A., Luck, A. J., Hopwood, J. J., & Hemsley, K. M. (2016). A preclinical study evaluating AAVrh10-based gene therapy for Sanfilippo syndrome. Human Gene Therapy, 27(5), 363-375. DOI Scopus37 WoS35 Europe PMC25 |
2015 |
Whyte, L. S., Hopwood, J. J., Hemsley, K. M., & Lau, A. A. (2015). Variables influencing fluorimetric N-sulfoglucosamine sulfohydrolase (SGSH) activity measurement in brain homogenates. Molecular Genetics and Metabolism Reports, 5, 60-62. DOI Scopus5 WoS4 Europe PMC4 |
2014 |
Trim, P., Lau, A., Hopwood, J., & Snel, M. (2014). A simple method for early age phenotype confirmation using toe tissue from a mouse model of MPS IIIA. Rapid Communications in Mass Spectrometry, 28(8), 933-938. DOI Scopus24 WoS23 Europe PMC15 |
2013 |
Lau, A., Shamsani, N., Winner, L., Hassiotis, S., King, B., Hopwood, J., & Hemsley, K. (2013). Neonatal bone marrow transplantation in MPS IIIA mice. JIMD Reports, 8, 121-132. DOI Scopus20 Europe PMC14 |
2012 |
Lau, A., Rozaklis, T., Ibanes, S., Luck, A., Beard, H., Hassiotis, S., . . . Hemsley, K. (2012). Helper-dependent canine adenovirus vector-mediated transgene expression in a neurodegenerative lysosomal storage disorder. Gene, 491(1), 53-57. DOI Scopus24 WoS21 Europe PMC17 |
2010 |
Lau, A., Hannouche, H., Rozaklis, T., Hassiotis, S., Hopwood, J., & Hemsley, K. (2010). Allogeneic stem cell transplantation does not improve neurological deficits in mucopolysaccharidosis type IIIA mice. Experimental Neurology, 225(2), 445-454. DOI Scopus32 WoS30 Europe PMC26 |
2010 |
Lau, A., Hopwood, J., Kremer, E., & Hemsley, K. (2010). SGSH gene transfer in mucopolysaccharidosis type IIIA mice using canine adenovirus vectors. Molecular Genetics and Metabolism, 100(2), 168-175. DOI Scopus26 WoS26 Europe PMC16 |
2008 |
Lau, A., Crawley, A., Hopwood, J., & Hemsley, K. (2008). Open field locomotor activity and anxiety-related behaviors in mucopolysaccharidosis type IIIA mice. Behavioural Brain Research, 191(1), 130-136. DOI Scopus62 WoS57 Europe PMC45 |
2007 |
Fraldi, A., Hemsley, K., Crawley, A., Lombardi, A., Lau, A., Sutherland, L., . . . Hopwood, J. (2007). Functional correction of CNS lesions in an MPS-IIIA mouse model by intracerebral AAV-mediated delivery of sulfamidase and SUMF1 genes. Human Molecular Genetics, 16(22), 2693-2702. DOI Scopus103 WoS104 Europe PMC75 |
2006 |
Lau, A., Hemsley, K., Meedeniya, A., Robinson, A., & Hopwood, J. (2006). Directed differentiation and characterization of genetyically modified embryonic stem cells for therapy. Methods in Molecular Biology, 329, 471-484. DOI Scopus2 |
2004 |
Lau, A., Hemsley, K., Meedeniya, A., & Hopwood, J. (2004). In vitro characterization of genetically modified embryonic stem cells as a therapy for murine mucopolysaccharidosis type IIIA. Molecular Genetics and Metabolism, 81(2), 86-95. DOI Scopus7 WoS4 Europe PMC6 |