![Thanh Loc Nguyen](/sites/default/files/styles/profile_large/public/profile-images/33538.jpeg?itok=ZNFe3nXv)
Dr Thanh Loc Nguyen
Grant-Funded Researcher, TI&I Program
South Australian Immunogenomics Cancer Institute
Faculty of Health and Medical Sciences
Dr. Thanh Loc Nguyen completed his doctoral studies in 2021 at Sungkyunkwan University (Seoul, Republic of Korea) under the supervision of Prof. Jaeyun Kim. His research focuses on micro and nanoparticles for drug delivery and immunotherapy. Afterward, he was appointed as a Brain Korea 21 postdoctoral research fellow in the same group, where he worked on developing vaccines for the treatment of cancer, multiple sclerosis, and asthma. His research resulted in 2 US patents and was published in high-impact journals, including Nature Communications, Advanced Materials, ACS Nano, and Biomaterials. From 2021 to 2023, he was awarded the Creative Challenge Research funding grants from the National Research Foundation of Korea for his postdoctoral studies.
Dr. Nguyen has a keen interest in understanding the fundamental chemistry of materials that govern their characteristics and interactions with the immune system, particularly with dendritic cells and T cells. Dendritic cells act as sentinels of our immunity, capable of initiating or suppressing immune responses through their interactions with T cells. Dr. Nguyen has joined the Yang lab at SAiGENCI as a Grant-Funded Researcher (Level B) with the aim of developing biomaterials for enhanced cancer immunotherapy.
Research interests
- Cancer Immunotherapy
- Immune-biomaterials interactions
- Immunoengineering
- Tissue engineering and regenerative medicine
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Appointments
Date Position Institution name 2024 - ongoing Grant-Funded Researcher (Level B) University of Adelaide 2021 - 2024 BK21 Postdoctoral research fellow Sungkyunkwan University -
Language Competencies
Language Competency English Can read, write, speak, understand spoken and peer review Vietnamese Can read, write, speak, understand spoken and peer review -
Education
Date Institution name Country Title 2015 - 2021 Sungkyunkwan University South Korea PhD in Engineering 2010 - 2015 Ho Chi Minh City University of Technology Vietnam Bachelor in Engineering -
Postgraduate Training
Date Title Institution Country 2024 Grant-Funded Researcher University of Adelaide Australia 2021 - 2024 Postdoctoral fellow Sungkyunkwan University South Korea -
Research Interests
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Journals
Year Citation 2024 Nguyen, T. L., Phan, N. M., & Kim, J. (2024). Administration of ROS-Scavenging Cerium Oxide Nanoparticles Simply Mixed with Autoantigenic Peptides Induce Antigen-Specific Immune Tolerance against Autoimmune Encephalomyelitis. ACS Applied Materials and Interfaces, 16(26), 33106-33120.
2024 Trinh, T. A., Nguyen, T. L., & Kim, J. (2024). Lignin-Based Antioxidant Hydrogel Patch for the Management of Atopic Dermatitis by Mitigating Oxidative Stress in the Skin. ACS Applied Materials and Interfaces, 16(26), 33135-33148.
2024 Im, J., Choi, Y., Nguyen, T. L., Kim, M. K., & Kim, J. (2024). Injectable Mesocellular Foam Silica Microparticles with a Dual Role of Cell-Recruiting Scaffolds and Intracellular Delivery Vehicles for Enhanced Cancer Vaccine. Advanced Functional Materials, 34(25), 11 pages.
2024 Phan, N. M., Nguyen, T. L., Choi, Y., Mo, X. W., Trinh, T. A., Yi, G. R., & Kim, J. (2024). High Cellular Internalization of Virus-Like Mesoporous Silica Nanoparticles Enhances Adaptive Antigen-Specific Immune Responses against Cancer. ACS Applied Materials and Interfaces, 16(35), 45917-45928.
2023 Phan, N. M., Nguyen, T. L., Shin, H., Trinh, T. A., & Kim, J. (2023). ROS-Scavenging Lignin-Based Tolerogenic Nanoparticle Vaccine for Treatment of Multiple Sclerosis. ACS Nano, 17(24), 24696-24709.
Scopus3 Europe PMC12023 Trinh, T. A., Le, T. M. D., Nguyen, H. T. T., Nguyen, T. L., Kim, J., Huynh, D. P., & Lee, D. S. (2023). pH-temperature Responsive Hydrogel-Mediated Delivery of Exendin-4 Encapsulated Chitosan Nanospheres for Sustained Therapeutic Efficacy in Type 2 Diabetes Mellitus. Macromolecular Bioscience, 23(11), 12 pages.
Scopus12022 Nguyen, T. L., & Kim, J. (2022). Nanoparticle-Based Tolerogenic Vaccines for the Treatment of Autoimmune Diseases: A Review. ACS Applied Nano Materials, 5(5), 6013-6028.
Scopus62022 Phan, V. H. G., Murugesan, M., Manivasagan, P., Nguyen, T. L., Phan, T. H., Luu, C. H., . . . Thambi, T. (2022). Injectable Hydrogel Based on Protein-Polyester Microporous Network as an Implantable Niche for Active Cell Recruitment. Pharmaceutics, 14(4), 17 pages.
Scopus11 Europe PMC62022 Kim, Y. E., Choi, S. W., Kim, M. K., Nguyen, T. L., & Kim, J. (2022). Therapeutic Hydrogel Patch to Treat Atopic Dermatitis by Regulating Oxidative Stress. Nano Letters, 22(5), 2038-2047.
Scopus41 Europe PMC112022 Nguyen, T. L., Choi, Y., Im, J., Shin, H., Phan, N. M., Kim, M. K., . . . Kim, J. (2022). Immunosuppressive biomaterial-based therapeutic vaccine to treat multiple sclerosis via re-establishing immune tolerance. Nature Communications, 13(1), 15 pages.
Scopus19 Europe PMC82022 Phan, N. M., Nguyen, T. L., & Kim, J. (2022). Nanozyme-Based Enhanced Cancer Immunotherapy. Tissue Engineering and Regenerative Medicine, 19(2), 237-252.
Scopus29 Europe PMC102022 Ji, D., Park, J. M., Oh, M. S., Nguyen, T. L., Shin, H., Kim, J. S., . . . Kim, J. (2022). Superstrong, superstiff, and conductive alginate hydrogels. Nature Communications, 13(1), 10 pages.
Scopus170 Europe PMC262021 Ji, D., Nguyen, T. L., & Kim, J. (2021). Bioinspired Structural Composite Hydrogels with a Combination of High Strength, Stiffness, and Toughness. Advanced Functional Materials, 31(28), 8 pages.
Scopus262020 Nguyen, T. L., Cha, B. G., Choi, Y., Im, J., & Kim, J. (2020). Injectable dual-scale mesoporous silica cancer vaccine enabling efficient delivery of antigen/adjuvant-loaded nanoparticles to dendritic cells recruited in local macroporous scaffold. Biomaterials, 239, 11 pages.
Scopus88 Europe PMC332020 Duong, H. T. T., Thambi, T., Yin, Y., Kim, S. H., Nguyen, T. L., Phan, V. H. G., . . . Lee, D. S. (2020). Degradation-regulated architecture of injectable smart hydrogels enhances humoral immune response and potentiates antitumor activity in human lung carcinoma. Biomaterials, 230, 12 pages.
Scopus81 Europe PMC322020 Nguyen, T. L., Yin, Y., Choi, Y., Jeong, J. H., & Kim, J. (2020). Enhanced Cancer DNA Vaccine via Direct Transfection to Host Dendritic Cells Recruited in Injectable Scaffolds. ACS Nano, 14(9), 11623-11636.
Scopus40 Europe PMC152020 Lee, J. Y., Kim, M. K., Nguyen, T. L., & Kim, J. (2020). Hollow Mesoporous Silica Nanoparticles with Extra-Large Mesopores for Enhanced Cancer Vaccine. ACS Applied Materials and Interfaces, 12(31), 34658-34666.
Scopus76 Europe PMC232019 Giang Phan, V. H., Duong, H. T. T., Thambi, T., Nguyen, T. L., Turabee, M. H., Yin, Y., . . . Lee, D. S. (2019). Modularly engineered injectable hybrid hydrogels based on protein-polymer network as potent immunologic adjuvant in vivo. Biomaterials, 195, 100-110.
Scopus46 Europe PMC132019 Le, T. M. D., Jung, B. K., Li, Y., Duong, H. T. T., Nguyen, T. L., Hong, J. W., . . . Lee, D. S. (2019). Physically crosslinked injectable hydrogels for long-term delivery of oncolytic adenoviruses for cancer treatment. Biomaterials Science, 7(10), 4195-4207.
Scopus35 Europe PMC142019 Nguyen, T. L., Choi, Y., & Kim, J. (2019). Mesoporous Silica as a Versatile Platform for Cancer Immunotherapy. Advanced Materials, 31(34), 17 pages.
Scopus172 Europe PMC532019 Sinha, A., Choi, Y., Nguyen, M. H., Nguyen, T. L., Choi, S. W., & Kim, J. (2019). A 3D Macroporous Alginate Graphene Scaffold with an Extremely Slow Release of a Loaded Cargo for In Situ Long-Term Activation of Dendritic Cells. Advanced Healthcare Materials, 8(5), 10 pages.
Scopus33 Europe PMC142019 Yin, Y., Nguyen, T. L., Wang, B., Duong, H. T. T., Lee, D. S., Kim, J. H., . . . Jeong, J. H. (2019). Simultaneous delivery of DNA vaccine and hydrophobic adjuvant using reducible polyethylenimine-functionalized graphene oxide for activation of dendritic cells. Journal of Industrial and Engineering Chemistry, 80, 870-876.
Scopus152018 Duong, H. T. T., Yin, Y., Thambi, T., Nguyen, T. L., Giang Phan, V. H., Lee, M. S., . . . Lee, D. S. (2018). Smart vaccine delivery based on microneedle arrays decorated with ultra-pH-responsive copolymers for cancer immunotherapy. Biomaterials, 185, 13-24.
Scopus152 Europe PMC432017 Sinha, A., Cha, B. G., Choi, Y., Nguyen, T. L., Yoo, P. J., Jeong, J. H., & Kim, J. (2017). Carbohydrate-Functionalized rGO as an Effective Cancer Vaccine for Stimulating Antigen-Specific Cytotoxic T Cells and Inhibiting Tumor Growth. Chemistry of Materials, 29(16), 6883-6892.
Scopus27 -
Patents
Year Citation 2024 Nguyen, T. L., & Jaeyun, K. (2024). US 11,890,332 B2, Dual-scale porous silica particle-based composition for preventing or treating cancer. United States. 2023 Nguyen, T. L., & Jaeyun, K. (2023). US 2023/0241190 A1, Vaccine for treating multiple sclerosis. United States.
- 2021.03 - 2024.02: Brain Korea 21 Postdoctoral Fellowship
- 2021.06 - 2022.05: National Research Foundation of Korea (NRF, 2021R1I1A1A01059165), Role: PI, Grant amount: 70M KRW
- 2022.06 - 2023.05: National Research Foundation of Korea (NRF, 2022R1I1A1A01073332), Role: PI, Grant amount: 70M KRW
2024 Spring semester: Advanced Engineering of Biomaterials (4420_BIOPRENG_7109), The University of Adelaide
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Review, Assessment, Editorial and Advice
Date Title Type Institution Country 2024 - ongoing Nature Nanotechnology Peer Review N/A - 2023 - ongoing Journal of Nanobiotechnology Peer Review N/A - 2023 - ongoing Cancer Immunology, Immunotherapy Peer Review N/A -
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