Mrs Nicole Isaacs
Clinical Research Coordinator │ Senior Research Assistant
Adelaide Medical School & NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health │The University of Adelaide
Intestinal Nutrient Sensing Group │ Centre for Nutrition & Gastrointestinal Diseases │ South Australian Health & Medical Research institute (SAHMRI)
Nicole is Clinical Research Coordinator for A/Professor Richard L Young
There are a number of Clinical Trial’s underway requiring volunteers.
Students are also encouraged to enquire regarding Honours and Postdoctoral studies.
Please contact Nicole for more information.
Clinical Studies currently underway (January 2017) ...
Study 1: Artificial Sweetener Study
Community based study involving healthy volunteers, looking at how signals in the intestine control the uptake of sugar into the body, and whether these pathways are altered by diet supplementation with artificial sweeteners.
Study 3: Sweet Taste Study - Diabetes Clinical Trial
The aim of this research is to understand how the gut senses sugars, and then regulates the uptake of sugar into the blood steam in people with Type 2 Diabetes.
|2017||Cvijanovic,N, Isaacs,NJ, Rayner,CK, Feinle-Bisset,C, Young,RL, Little,TJ, 2017, Lipid stimulation of fatty acid sensors in the human duodenum: relationship with gastrointestinal hormones, BMI and diet., Int J Obes (Lond), 41, 2, 233-239 10.1038/ijo.2016.199|
|2016||Cvijanovic,N, Isaacs,NJ, Rayner,CK, Feinle-Bisset,C, Young,RL, Little,TJ, 2016, Duodenal fatty acid sensor and transporter expression following acute fat exposure in healthy lean humans, Clinical Nutrition, Online, 1-6 10.1016/j.clnu.2016.02.005|
|2014||Little,TJ, Isaacs,NJ, Young,RL, Ott,R, Nguyen,NQ, Rayner,CK, Horowitz,M, Feinle-Bisset,C, 2014, Characterization of duodenal expression and localization of fatty acid-sensing receptors in humans: relationships with body mass index, American Journal of Physiology. Gastrointestinal and Liver Physiology, 307, 10, G958-G967 10.1152/ajpgi.00134.2014|
|2013||Li,H, Kentish,S, Kritas,S, Young,R, Isaacs,N, O'Donnell,T, Blackshaw,L, Wittert,G, Page,A, 2013, Modulation of murine gastric vagal afferent mechanosensitivity by neuropeptide W, Acta Physiologica (Print Edition), 209, 2, 179-191 10.1111/apha.12154|
|2013||Hughes,P, Castro Kraftchenko,J, Harrington,A, Isaacs,N, Moretta,M, Hicks,G, Urso,D, Brierley,S, 2013, Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity, Gut, Online, 7, 1-2 10.1136/gutjnl-2013-306240|
|2013||Hughes,P, Harrington,A, Castro Kraftchenko,J, Liebregts,T, Adam,B, Grasby,D, Isaacs,N, Maldeniya,M, Martin,C, Persson,J et al, 2013, Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes, Gut, 62, 10, 1456-1465 10.1136/gutjnl-2011-301856|
|2013||Kentish,S, O'Donnell,T, Isaacs,N, Young,R, Li,H, Harrington,A, Brierley,S, Wittert,G, Blackshaw,L, Page,A et al, 2013, Gastric vagal afferent modulation by leptin is influenced by food intake status, Journal of Physiology-London, 591, 7, 1921-1934 10.1113/jphysiol.2012.247577|
|2013||Young,R, Chia,C, Isaacs,N, Ma,J, Khoo,J, Wu,T, Horowitz,M, Rayner,C, 2013, Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes, Diabetes, 62, 10, 3532-3541 10.2337/db13-0581|
|2013||Harrington,A, Brierley,S, Isaacs,N, Young,R, Blackshaw,L, 2013, Identifying spinal sensory pathways activated by noxious esophageal acid, Neurogastroenterology and Motility, 25, 10, 660-668 10.1111/nmo.12180|
|2012||Harrington,A, Brierley,S, Isaacs,N, Hughes,P, Castro Kraftchenko,J, Blackshaw,L, 2012, Sprouting of colonic afferent central terminals and increased spinal mitogen-activated protein kinase expression in a mouse model of chronic visceral hypersensitivity, Journal of Comparative Neurology, 520, 10, 2241-2255 10.1002/cne.23042|
|2012||Kentish,S, Li,H, Philp,L, O'Donnell,T, Isaacs,N, Young,R, Wittert,G, Blackshaw,L, Page,A, 2012, Diet-induced adaptation of vagal afferent function, Journal of Physiology-London, 590, 1, 209-221 10.1113/jphysiol.2011.222158|
|2011||Harrington,A, Hughes,P, Martin,C, Yang,J, Castro,J, Isaacs,N, Blackshaw,L, Brierley,S, 2011, A novel role for TRPM8 in visceral afferent function, PAIN®, 152, 7, 1459-1468 10.1016/j.pain.2011.01.027|
|2010||Young,R, Page,A, Isaacs,N, Flach,C, Blackshaw,L, 2010, Sensory and Motor Innervation of the Crural Diaphragm by the Vagus Nerves, Gastroenterology, 138, 3, 1091-1106 10.1053/j.gastro.2009.08.053|
|2010||Isaacs,NJ, Young,RL, Wittert,G, Blackshaw,LA, Page,AJ, 2010, Anatomy of gastric vagal afferent innervation in normal and obese mice, NEUROGASTROENTEROLOGY AND MOTILITY, 22, 9-9|
|2009||Page,A, O'Donnell,T, Isaacs,N, Young,R, Blackshaw,L, 2009, Nitric Oxide as an Endogenous Peripheral Modulator of Visceral Sensory Neuronal Function, Journal of Neuroscience, 29, 22, 7246-7255 10.1523/JNEUROSCI.6099-08.2009|
|2009||Brierley,S, Hughes,P, Page,A, Kwan,K, Martin,C, O'Donnell,T, Isaacs,N, Harrington,A, Adam,B, Liebregts,T et al, 2009, The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli, Gastroenterology, 137, 6, 2084-2095 10.1053/j.gastro.2009.07.048|
|2008||Young,R, Isaacs,N, Blackshaw,L, 2008, Chemical coding and central projections of gastric vagal afferent neurons, Neurogastroenterology and Motility, 20, 6, 708-718 10.1111/j.1365-2982.2007.01071.x|
|2008||Young,R, Isaacs,N, Blackshaw,L, 2008, Anatomy and function of group III metabotropic glutamate receptors in gastric vagal pathways, Neuropharmacology, 54, 6, 965-975 10.1016/j.neuropharm.2008.02.010|
|2008||Brierley,S, Page,A, Hughes,P, Adam,B, Liebregts,T, Isaacs,N, Holtmann,G, Liedtke,W, Blackshaw,L, 2008, Selective role for TRPV4 ion channels in visceral sensory pathways, Gastroenterology, 134, 7, 2059-2069 10.1053/j.gastro.2008.01.074|
|2007||Young,R, Page,A, Isaacs,N, O'Donnell,T, Blackshaw,L, 2007, Peripheral versus central modulation of gastric vagal pathways by metabotropic glutamate receptor 5, American Journal of Physiology-Gastrointestinal and Liver Physiology, 292, 2, G501-G511 10.1152/ajpgi.00353.2006|
|2007||Sutherland,K, Young,R, Isaacs,N, Horowitz,M, Blackshaw,L, 2007, Phenotypic characterization of taste cells of the mouse small intestine, American Journal of Physiology-Gastrointestinal and Liver Physiology, 292, 5, G1420-G1428 10.1152/ajpgi.00504.2006|
|2005||Page,A, Slattery,J, O'Donnell,T, Isaacs,N, Young,R, Blackshaw,L, 2005, Modulation of gastro-oesophageal vagal afferents by galanin in mouse and ferret, Journal of Physiology-London, 563, 3, 809-819 10.1113/jphysiol.2004.075291|
|2005||Page,A, Young,R, Martin,C, Umaerus,M, O'Donnell,T, Isaacs,N, Coldwell,J, Hulander,M, Mattsson,J, Lehmann,A et al, 2005, Metabotropic glutamate receptors inhibit mechanosensitivity in vagal sensory neurons, Gastroenterology, 128, 2, 402-410 10.1053/j.gastro.2004.11.062|
|2001||Isaacs,N, McClean,R, Leigh,C, Breed,W, 2001, Glycoconjugates on the surface of epididymal spermatozoa in a marsupial, the brushtail possum, Trichosurus vulpecula, Reproduction, 122, 1, 165-176 10.1530/rep.0.1220165|
|2001||Smid,S, Young,R, Isaacs,N, Blackshaw,L, 2001, GABABR expressed on vagal afferent neurones inhibit gastric mechanosensitivity in ferret proximal stomach, American Journal of Physiology-Gastrointestinal and Liver Physiology, 281, 6, G1494-G1501|
|2003||Brierley,S, Coldwell,J, Isaacs,N, Howarth,G, Blackshaw,L, 2003, Colonic spinal primary afferents: mechanosensory and chemosensory subtypes and effects of inflammation, Kluwer Academic Publishers, PO Box 17, 3300AA Dordrecht, The Netherlands, pp. 120-125|
|2010||Isaacs,N, Flach,C, Young,R, Wittert,G, Blackshaw,L, Page,A, 2010, Anatomy of gastric vagal afferent-leptin interactions in normal and obese mice 10.1016/S0016-5085(10)62805-3|
|2009||Harrington,A, Hughes,P, Martin,C, Isaacs,N, Brierley,S, Blackshaw,L, 2009, Localisation and function of transient receptor potential ion channel melastatin subtype 8 (TRPM8) in mouse colonic primary afferent nerve fibers, Congress of the International Society for Autonomic Neuroscience - ISAN, Sydney, Australia 10.1016/j.autneu.2009.05.028|
|2012||Hughes,P, Nicholson,I, Bird,D, To,S, Isaacs,N, Grasby,D, Persson,J, Harrington,A, Brierley,S, Zola,H et al, 2012, C-IBS patients lack monocyte derived β-endorphin which results in disinhibition of colonic afferent mechanosensitivity, Digestive Disease Week, San Diego 10.1016/S0016-5085(12)62702-4|
|2000||Isaacs,N, Breed,W, 2000, Changes in glycoprotein composition of the plasma membrane of brushtail possum spermatozoa, during epidydmal migration, FSA/ASRB 2000 - Thirty-first Annual Conference of the Australian Society for Reproductive Biology, Canberra, Australia|