Mrs Nicole Isaacs

Nicole Isaacs
Research Officer
Adelaide Medical School
Faculty of Health and Medical Sciences

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Mrs Nicole Isaacs

Clinical Research Coordinator │ Senior Research Assistant

Adelaide Medical School & NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health │The University of Adelaide

Intestinal Nutrient Sensing Group │ Centre for Nutrition & Gastrointestinal Diseases │ South Australian Health & Medical Research institute (SAHMRI)


Nicole is Clinical Research Coordinator for A/Professor Richard L Young

There are a number of Clinical Trial’s underway requiring volunteers.

Students are also encouraged to enquire regarding Honours and Postdoctoral studies.

Please contact Nicole for more information.


Clinical Studies currently underway (January 2017) ...


Study 1: Artificial Sweetener Study

Community based study involving healthy volunteers, looking at how signals in the intestine control the uptake of sugar into the body, and whether these pathways are altered by diet supplementation with artificial sweeteners.

Artificial Sweetener Study


Study 3: Sweet Taste Study - Diabetes Clinical Trial

The aim of this research is to understand how the gut senses sugars, and then regulates the uptake of sugar into the blood steam in people with Type 2 Diabetes.

Sweet Taste Study


Date Citation
2017 Cvijanovic,N, Isaacs,NJ, Rayner,CK, Feinle-Bisset,C, Young,RL, Little,TJ, 2017, Lipid stimulation of fatty acid sensors in the human duodenum: relationship with gastrointestinal hormones, BMI and diet., Int J Obes (Lond), 41, 2, 233-239 10.1038/ijo.2016.199
2016 Cvijanovic,N, Isaacs,NJ, Rayner,CK, Feinle-Bisset,C, Young,RL, Little,TJ, 2016, Duodenal fatty acid sensor and transporter expression following acute fat exposure in healthy lean humans, Clinical Nutrition, Online, 1-6 10.1016/j.clnu.2016.02.005
2014 Little,TJ, Isaacs,NJ, Young,RL, Ott,R, Nguyen,NQ, Rayner,CK, Horowitz,M, Feinle-Bisset,C, 2014, Characterization of duodenal expression and localization of fatty acid-sensing receptors in humans: relationships with body mass index, American Journal of Physiology. Gastrointestinal and Liver Physiology, 307, 10, G958-G967 10.1152/ajpgi.00134.2014
2013 Li,H, Kentish,S, Kritas,S, Young,R, Isaacs,N, O'Donnell,T, Blackshaw,L, Wittert,G, Page,A, 2013, Modulation of murine gastric vagal afferent mechanosensitivity by neuropeptide W, Acta Physiologica (Print Edition), 209, 2, 179-191 10.1111/apha.12154
2013 Hughes,P, Castro Kraftchenko,J, Harrington,A, Isaacs,N, Moretta,M, Hicks,G, Urso,D, Brierley,S, 2013, Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity, Gut, Online, 7, 1-2 10.1136/gutjnl-2013-306240
2013 Hughes,P, Harrington,A, Castro Kraftchenko,J, Liebregts,T, Adam,B, Grasby,D, Isaacs,N, Maldeniya,M, Martin,C, Persson,J et al, 2013, Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes, Gut, 62, 10, 1456-1465 10.1136/gutjnl-2011-301856
2013 Kentish,S, O'Donnell,T, Isaacs,N, Young,R, Li,H, Harrington,A, Brierley,S, Wittert,G, Blackshaw,L, Page,A et al, 2013, Gastric vagal afferent modulation by leptin is influenced by food intake status, Journal of Physiology-London, 591, 7, 1921-1934 10.1113/jphysiol.2012.247577
2013 Young,R, Chia,C, Isaacs,N, Ma,J, Khoo,J, Wu,T, Horowitz,M, Rayner,C, 2013, Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes, Diabetes, 62, 10, 3532-3541 10.2337/db13-0581
2013 Harrington,A, Brierley,S, Isaacs,N, Young,R, Blackshaw,L, 2013, Identifying spinal sensory pathways activated by noxious esophageal acid, Neurogastroenterology and Motility, 25, 10, 660-668 10.1111/nmo.12180
2012 Harrington,A, Brierley,S, Isaacs,N, Hughes,P, Castro Kraftchenko,J, Blackshaw,L, 2012, Sprouting of colonic afferent central terminals and increased spinal mitogen-activated protein kinase expression in a mouse model of chronic visceral hypersensitivity, Journal of Comparative Neurology, 520, 10, 2241-2255 10.1002/cne.23042
2012 Kentish,S, Li,H, Philp,L, O'Donnell,T, Isaacs,N, Young,R, Wittert,G, Blackshaw,L, Page,A, 2012, Diet-induced adaptation of vagal afferent function, Journal of Physiology-London, 590, 1, 209-221 10.1113/jphysiol.2011.222158
2011 Harrington,A, Hughes,P, Martin,C, Yang,J, Castro,J, Isaacs,N, Blackshaw,L, Brierley,S, 2011, A novel role for TRPM8 in visceral afferent function, PAIN®, 152, 7, 1459-1468 10.1016/j.pain.2011.01.027
2010 Young,R, Page,A, Isaacs,N, Flach,C, Blackshaw,L, 2010, Sensory and Motor Innervation of the Crural Diaphragm by the Vagus Nerves, Gastroenterology, 138, 3, 1091-1106 10.1053/j.gastro.2009.08.053
2010 Isaacs,NJ, Young,RL, Wittert,G, Blackshaw,LA, Page,AJ, 2010, Anatomy of gastric vagal afferent innervation in normal and obese mice, NEUROGASTROENTEROLOGY AND MOTILITY, 22, 9-9
2009 Page,A, O'Donnell,T, Isaacs,N, Young,R, Blackshaw,L, 2009, Nitric Oxide as an Endogenous Peripheral Modulator of Visceral Sensory Neuronal Function, Journal of Neuroscience, 29, 22, 7246-7255 10.1523/JNEUROSCI.6099-08.2009
2009 Brierley,S, Hughes,P, Page,A, Kwan,K, Martin,C, O'Donnell,T, Isaacs,N, Harrington,A, Adam,B, Liebregts,T et al, 2009, The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli, Gastroenterology, 137, 6, 2084-2095 10.1053/j.gastro.2009.07.048
2008 Young,R, Isaacs,N, Blackshaw,L, 2008, Chemical coding and central projections of gastric vagal afferent neurons, Neurogastroenterology and Motility, 20, 6, 708-718 10.1111/j.1365-2982.2007.01071.x
2008 Young,R, Isaacs,N, Blackshaw,L, 2008, Anatomy and function of group III metabotropic glutamate receptors in gastric vagal pathways, Neuropharmacology, 54, 6, 965-975 10.1016/j.neuropharm.2008.02.010
2008 Brierley,S, Page,A, Hughes,P, Adam,B, Liebregts,T, Isaacs,N, Holtmann,G, Liedtke,W, Blackshaw,L, 2008, Selective role for TRPV4 ion channels in visceral sensory pathways, Gastroenterology, 134, 7, 2059-2069 10.1053/j.gastro.2008.01.074
2007 Young,R, Page,A, Isaacs,N, O'Donnell,T, Blackshaw,L, 2007, Peripheral versus central modulation of gastric vagal pathways by metabotropic glutamate receptor 5, American Journal of Physiology-Gastrointestinal and Liver Physiology, 292, 2, G501-G511 10.1152/ajpgi.00353.2006
2007 Sutherland,K, Young,R, Isaacs,N, Horowitz,M, Blackshaw,L, 2007, Phenotypic characterization of taste cells of the mouse small intestine, American Journal of Physiology-Gastrointestinal and Liver Physiology, 292, 5, G1420-G1428 10.1152/ajpgi.00504.2006
2005 Page,A, Slattery,J, O'Donnell,T, Isaacs,N, Young,R, Blackshaw,L, 2005, Modulation of gastro-oesophageal vagal afferents by galanin in mouse and ferret, Journal of Physiology-London, 563, 3, 809-819 10.1113/jphysiol.2004.075291
2005 Page,A, Young,R, Martin,C, Umaerus,M, O'Donnell,T, Isaacs,N, Coldwell,J, Hulander,M, Mattsson,J, Lehmann,A et al, 2005, Metabotropic glutamate receptors inhibit mechanosensitivity in vagal sensory neurons, Gastroenterology, 128, 2, 402-410 10.1053/j.gastro.2004.11.062
2001 Isaacs,N, McClean,R, Leigh,C, Breed,W, 2001, Glycoconjugates on the surface of epididymal spermatozoa in a marsupial, the brushtail possum, Trichosurus vulpecula, Reproduction, 122, 1, 165-176 10.1530/rep.0.1220165
2001 Smid,S, Young,R, Isaacs,N, Blackshaw,L, 2001, GABABR expressed on vagal afferent neurones inhibit gastric mechanosensitivity in ferret proximal stomach, American Journal of Physiology-Gastrointestinal and Liver Physiology, 281, 6, G1494-G1501

Book Chapters

Date Citation
2003 Brierley,S, Coldwell,J, Isaacs,N, Howarth,G, Blackshaw,L, 2003, Colonic spinal primary afferents: mechanosensory and chemosensory subtypes and effects of inflammation, Kluwer Academic Publishers, PO Box 17, 3300AA Dordrecht, The Netherlands, pp. 120-125

Conference Papers

Date Citation
2010 Isaacs,N, Flach,C, Young,R, Wittert,G, Blackshaw,L, Page,A, 2010, Anatomy of gastric vagal afferent-leptin interactions in normal and obese mice 10.1016/S0016-5085(10)62805-3
2009 Harrington,A, Hughes,P, Martin,C, Isaacs,N, Brierley,S, Blackshaw,L, 2009, Localisation and function of transient receptor potential ion channel melastatin subtype 8 (TRPM8) in mouse colonic primary afferent nerve fibers, Congress of the International Society for Autonomic Neuroscience - ISAN, Sydney, Australia 10.1016/j.autneu.2009.05.028

Conference Items

Date Citation
2012 Hughes,P, Nicholson,I, Bird,D, To,S, Isaacs,N, Grasby,D, Persson,J, Harrington,A, Brierley,S, Zola,H et al, 2012, C-IBS patients lack monocyte derived β-endorphin which results in disinhibition of colonic afferent mechanosensitivity, Digestive Disease Week, San Diego 10.1016/S0016-5085(12)62702-4
2000 Isaacs,N, Breed,W, 2000, Changes in glycoprotein composition of the plasma membrane of brushtail possum spermatozoa, during epidydmal migration, FSA/ASRB 2000 - Thirty-first Annual Conference of the Australian Society for Reproductive Biology, Canberra, Australia
Research Officer
North Terrace West
Room Number
7 South
Org Unit
Medical Specialties