Dr Miranda Ween

Miranda Ween
Postdoctoral Research Fellow
Adelaide Medical School
Faculty of Health and Medical Sciences

Dr Ween in Completed her PhD in 2010 in Cancer biology and then undertook a postdoctoral position in the Research Centre for Infectious Diseases with a focus on lung pathogenic bacteria and metal biology. In 2015, Dr Ween was invited to join the Chronic Inflammatory Lung Disease Laboratory. Here she investigates how smoking affects inflammation in the lung, and the ability of macrophages to phagocytose lung pathogenic bacteria. Dr Ween also studies the mechanisms into COPD, a lung disease which affects up to 1.5 million Australians. She has also established herself as an Australian pioneer in E-cigarette research, and was invited to present to the SA Parliamentary enquiry into E-cigarettes in 2016.

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Dr Miranda Ween

Dr Ween in Completed her PhD in 2010 in Cancer biology and then undertook a postdoctoral position in the Research Centre for Infectious Diseases with a focus on lung pathogenic bacteria and metal biology. In 2015, Dr Ween was invited to join the Chronic Inflammatory Lung Disease Laboratory. Here she investigates how smoking affects inflammation in the lung, and the ability of macrophages to phagocytose lung pathogenic bacteria. Dr Ween also studies the mechanisms into COPD, a lung disease which affects up to 1.5 million Australians. She has also established herself as an Australian pioneer in E-cigarette research, and was invited to present to the SA Parliamentary enquiry into E-cigarettes in 2016.

Understanding the role macrophages play in COPD and other chronic inflammatory lung diseases

What effects do E-cigarettes have on the lung, and how much safer are they than cigarettes?

Investigating the role of the sphingosine rheostat in chronic inflammatory lung diseases

Appointments

Date Position Institution name
2016 National Asthma Council Career Development Fellow Royal Adelaide Hospital
2015 Adjunct Lecturer University of adelaide
2015 Posdtdoctoral Research Fellow Royal Adelaide Hospital
2010 - 2015 Postodctoral Research Fellow University of Adelaide

Awards and Achievements

Date Type Title Institution Name Amount
2017 International Journal of Molecular Science Travel Award
2017 Biochemical Society Travel Award
2016 Schiccitano Award Department of Thoracic Medicine, Royal Adelaide Hospital
2015 Lillian Roxon Asthma Australia Travel award National Asthma Council/TSANZ
2015 Finalist for THRF 50th anniversary award The Hospital Research Foundation
2013 Research Career Development Network Achievement Award School of Molecular Biosciences, University of Adelaide
2013 Executive Deans Order of Merit Faculty of Sciences, University of Adelaide
2013 Faculty of Sciences Research Excellence Award Finalist Faculty of Sciences, University of Adelaide
2013 CASS Foundation National Travel Grant
2013 I’m a Scientist national competition zone winner
2010 Robert Seamark Postgraduate Award Department of Obstetrics and Gynaecology, University of Adelaide

Education

Date Institution name Country Title
2010 University of Adelaide Australia Doctorate of Philosophy in Cancer Biology
2006 University of Adelaide Australia Diploma of Languages in French
2005 University of Adelaide Australia Bachelor of Science (Hons) in Cell Biology
2004 University of Adelaide Australia Bachelor Science (Biomedical Science) Majoring in Immunity & Infection and Human Physiology

Keywords

Cell Biology, Cellular Immunology, Infectious Diseases, Respiratory Diseases

Journals

Date Citation
2017 Hodge,S, Tran,H, Hamon,R, Roscioli,E, Hodge,G, Jersmann,H, Ween,M, Reynolds,P, Yeung,A, Treiberg,J et al, 2017, Nonantibiotic macrolides restore airway macrophage phagocytic function with potential anti-inflammatory effects in chronic lung diseases, American Journal of Physiology - Lung Cellular and Molecular Physiology, 312, 5, L678-L687 10.1152/ajplung.00518.2016
2017 Ricciardelli,C, Lokman,N, Pyragius,C, Ween,M, Macpherson,A, Ruszkiewicz,A, Hoffmann,P, Oehler,M, 2017, Keratin 5 overexpression is associated with serous ovarian cancer recurrence and chemotherapy resistance, Oncotarget, 8, 11, 17819-17832 10.18632/oncotarget.14867
2016 Tran,H, Barnawi,J, Ween,M, Hamon,R, Roscioli,E, Hodge,G, Reynolds,P, Pitson,S, Davies,L, Haberberger,R et al, 2016, Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720, Journal of Leukocyte Biology, 100, 1, 195-202 10.1189/jlb.3A1015-471R
2016 Ricciardelli,C, Lokman,N, Ween,M, Oehler,M, 2016, Ovarian cancer-peritoneal cell interactions promote extracellular matrix processing, Endocrine-Related Cancer, 23, 11, T155-T168 10.1530/ERC-16-0320
2016 Ween,M, Ahern,J, Carroll,A, Hodge,G, Pizzutto,S, Jersmann,H, Reynolds,P, Hodge,S, 2016, A small volume technique to examine and compare alveolar macrophage phagocytosis of apoptotic cells and non typeable Haemophilus influenzae (NTHi), Journal of Immunological Methods, 429, 7-14 10.1016/j.jim.2015.12.004
2016 Ween,M, Reynolds,P, Hodge,S, 2016, Hidden dangers of E-cigarettes: Airway macrophage dysfunction and altered inflammatory response, European Respiratory Journal, 48, suppl 60, OA4981-OA4981 10.1183/13993003.congress-2016.OA4981
2015 Pederick,V, Eijkelkamp,B, Begg,S, Ween,M, McAllister,L, Paton,J, McDevitt,C, 2015, ZnuA and zinc homeostasis in pseudomonas aeruginosa, Scientific Reports, 5, 13139-1-13139-14 10.1038/srep13139
2015 Bajaj,M, Mamidyala,S, Zuegg,J, Begg,S, Ween,M, Luo,Z, Huang,J, McEwan,A, Kobe,B, Paton,J et al, 2015, Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach, ACS Chemical Biology, 10, 6, 1511-1520 10.1021/cb501032x
2015 Ween,M, Armstrong,M, Oehler,M, Ricciardelli,C, 2015, The role of ABC transporters in ovarian cancer progression and chemoresistance, Critical Reviews in Oncology/Hematology, 96, 2, 220-256 10.1016/j.critrevonc.2015.05.012
2015 Ricciardelli,C, Lokman,N, Cheruvu,S, Tan,I, Ween,M, Pyragius,C, Ruszkiewicz,A, Hoffmann,P, Oehler,M, 2015, Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation, Clinical & Experimental Metastasis, 32, 5, 441-455 10.1007/s10585-015-9718-1
2014 Counago,R, Ween,M, Begg,S, Bajaj,M, Zuegg,J, O'Mara,M, Cooper,M, McEwan,A, Paton,J, Kobe,B et al, 2014, Imperfect coordination chemistry facilitates metal ion release in the Psa permease, Nature Chemical Biology, 10, 1, 35-43 10.1038/NCHEMBIO.1382
2014 Eijkelkamp,B, Morey,J, Ween,M, Ong,C, McEwan,A, Paton,J, McDevitt,C, 2014, Extracellular zinc competitively inhibits manganese uptake and compromises oxidative stress management in Streptococcus pneumoniae, PLoS One, 9, 2, e89427-1-e89427-11 10.1371/journal.pone.0089427
2014 Pederick,V, Eijkelkamp,B, Ween,M, Begg,S, Paton,J, McDevitt,C, 2014, Acquisition and role of molybdate in Pseudomonas aeruginosa, Applied and Environmental Microbiology, 80, 21, 6843-6852 10.1128/aem.02465-14
2013 Ricciardelli,C, Ween,M, Lokman,N, Tan,I, Pyragius,C, Oehler,M, 2013, Chemotherapy-induced hyaluronan production: a novel chemoresistance mechanism in ovarian cancer, BMC Cancer, 13, 476, 1-12 10.1186/1471-2407-13-476
2013 Lokman,N, Elder,A, Ween,M, Pyragius,C, Hoffmann,P, Oehler,M, Ricciardelli,C, 2013, Annexin A2 is regulated by ovarian cancer-peritoneal cell interactions and promotes metastasis, Oncotarget, 4, 8, 1199-1211 10.18632/oncotarget.1122
2012 Counago,R, McDevitt,C, Ween,M, Kobe,B, 2012, Prokaryotic substrate-binding proteins as targets for antimicrobial therapies, Current Drug Targets, 13, 11, 1400-1410 10.2174/138945012803530170
2012 Pederick,V, Ween,M, McDevitt,C, 2012, The role of ATP-binding cassette transporters in bacterial pathogenicity, Protoplasma, 249, 4, 919-942 10.1007/s00709-011-0360-8
2012 Ween,M, Oehler,M, Ricciardelli,C, 2012, Transforming growth factor-beta-induced protein (TGFBI)/(βig-H3): a matrix protein with dual functions in ovarian cancer, International Journal of Molecular Sciences, 13, 8, 10461-10477 10.3390/ijms130810461
2011 Ween,M, Oehler,M, Ricciardelli,C, 2011, Role of versican, hyaluronan and CD44 in ovarian cancer metastasis, International Journal of Molecular Sciences (Online), 12, 2, 1009-1029 10.3390/ijms12021009
2011 Ween,M, Hummitzsch,K, Rodgers,R, Oehler,M, Ricciardelli,C, 2011, Versican induces a pro-metastatic ovarian cancer cell behavior which can be inhibited by small hyaluronan oligosaccharides, Clinical & Experimental Metastasis, 28, 2, 113-125 10.1007/s10585-010-9363-7
2011 Ween,M, Lokman,N, Hoffmann,P, Rodgers,R, Ricciardelli,C, Oehler,M, 2011, Transforming growth factor-beta-induced protein secreted by peritoneal cells increases the metastatic potential of ovarian cancer cells, International Journal of Cancer, 128, 7, 1-15 10.1002/ijc.25494
2011 Lokman,N, Ween,M, Oehler,M, Ricciardelli,C, 2011, The role of annexin A2 in tumorigenesis and cancer progression, Cancer Microenvironment, 4, 2, 199-208 10.1007/s12307-011-0064-9
2009 Ricciardelli,C, Sakko,A, Ween,M, Russell,D, Horsfall,D, 2009, The biological role and regulation of versican levels in cancer, Cancer and Metastasis Reviews, 28, 1-2, 233-245 10.1007/s10555-009-9182-y
2007 Ricciardelli,C, Russell,D, Ween,M, Mayne,K, Suwiwat,S, Byers,S, Marshall,V, Tilley,W, Horsfall,D, 2007, Formation of hyaluronan- and versican-rich pericellular matrix by prostate cancer cells promotes cell motility, Journal of Biological Chemistry, 282, 14, 10814-10825 10.1074/jbc.M606991200

Book Chapters

Date Citation
2009 Ricciardelli,C, Sakko,A, Ween,M, Russell,D, Horsfall,D, 2009, The proteoglycan versican: an important regulator of cell locomotion in development and disease, Nova Science Publishers, pp. 1-19

Conference Papers

Date Citation
2017 Ween,M, Whittall,J, Hodge,S, 2017, E-CIGARETTES CAUSE INCREASED CELL DEATH, APOPTOSIS AND ALTERED CYTOKINE PROFILE OF HUMAN BRONCHIAL EPITHELIAL CELLS
2017 Whittall,J, Ween,M, Hodge,S, 2017, INNATE IMMUNE MACROPHAGE RESPONSE TO NTHI AND AZITHROMYCIN IN COPD
2017 Tran,HB, Hamon,R, Truong,TT, Ween,M, Riscioli,E, Jerssman,H, Hodge,G, Reynolds,P, Hodge,S, 2017, CIGARETTE SMOKE-INDUCED INFLAMMATION IN MACROPHAGES IS INITIATED BY NLRP3/AIM2 INFLAMMASOMES: INVOLVEMENT OF THE SPHINGOSINE-1-PHOSPHATE (S1P) SIGNALLING
2011 Ricciardelli,C, Lokman,NA, Ween,MP, Hoffman,P, Oehler,MK, 2011, Role of annexin A2 in ovarian cancer metastasis

Conference Items

Date Citation
2017 Ween,M, Jones,C, Tran,H, Whittall,J, Hodge,S, 2017, Investigation of the CD1b lipid antigen presentation pathway In pulmonary COPD, The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ)Annual Scientific Meeting 2017, Canberra, Australia 10.1111/resp.13010
2015 Lokman,NA, Elder,AS, Ween,MP, Pyragius,CE, Hoffmann,P, Ruszkiewicz,A, Oehler,MK, Ricciardelli,C, 2015, Annexin A2 a potential prognostic marker for serous ovarian cancer promotes ovarian cancer metastasis
2015 Pederick,VG, Eijkelkamp,BA, Begg,SL, Ween,MP, McAllister,LJ, Paton,JC, McDevitt,CA, 2015, ZnuA and zinc homeostasis in Pseudomonas aeruginosa, BacPath 13: Molecular Analysis of Bacterial Pathogens Conference 2015, Phillip Island, VIC
2015 Pederick,VG, Begg,SL, eijkelkamp,BA, ween,MP, Paton,JC, McDevitt,CA, 2015, Metal uptake transporters – a microbial Achilles heel, An exchange workshop on antimicrobial resistance, UniSA
2015 Ricciardelli,C, Cheruvu,S, Lokman,NA, Ween,MP, Tan,IA, Pyragius,CE, Ruszkiewicz,A, Oehler,MK, 2015, Transketolase a protein regulated by ovarian cancer-peritoneal interactions is elevated in omental metastases and regulates serous ovarian cancer proliferation
2014 Lokman,N, Elder,A, Ween,M, Pyragius,C, Hoffmann,P, Ruszkiewicz,A, Ricciardelli,C, Oehler,M, 2014, ANNEXIN A2 A POTENTIAL PROGNOSTIC MARKER FOR SEROUS OVARIAN CANCER PROMOTES OVARIAN CANCER METATASIS
2013 Pederick,VG, Eijkelkamp,BA, Ween,MP, Begg,SL, Paton,JC, McDevitt,CA, 2013, The role of molybdenum in Pseudomonas aeruginosa persistence, School of Molecular and Biomedical Sciences 3-Minute Thesis competition
2011 Pederick,VG, Ween,MP, Paton,JC, McDevitt,CA, 2011, Biochemical characterisation of PA1876, a Pseudomonas aeruginosa multidrug ATP-binding cassette transporter, Adelaide Protein Group
2011 Pederick,VG, Ween,MP, Paton,JC, McDevitt,CA, 2011, Biochemical characterisation of PA1876, a novel Pseudomonas aeruginosa multidrug ATP-binding cassette transporter, School of Molecular and Biomedical Science Research Symposium
2011 Pederick,VG, Ween,MP, Paton,JC, McDevitt,CA, 2011, Biochemical characterisation of PA1876, a novel Pseudomonas aeruginosa multidrug ATP-binding cassette transporter, Australian Society for Medical Research SA Meeting

2016                           Royal Adelaide Hospital Clinical Project Grant ($50,000)

2016                           National Asthma Council/Thoracic Society for Australia and New Zealand Asthma and Airways career development fellowship ($60,000)

2006 – 2009               Practical Demonstrator, School of Molecular and Biomedical Sciences, Adelaide University

2008 – 2010               CBL/PBL Tutor, School of Medicine, Adelaide University

2010 – 2015               School of Molecular Biosciences Centrifuge Trainer

2014 – 2015               Masters of Biotechnology Guest Lecturer

2016                           Honours Co-supervisor

2011                           Co-supervision of Honours student

2012                           Supervision of Summer Scholarship student

2016                           Honours Co-supervisor

 

Position
Postdoctoral Research Fellow
Phone
83137082
Campus
North Terrace
Building
Adelaide Health and Medical Sciences Building
Room Number
WS7050.05
Org Unit
Medicine

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