Dr Md Rahman
Research Fellow - DRMCRL
Adelaide Medical School
Faculty of Health and Medical Sciences
Since 1st March 2016, I have been working at Dame Roma Mitchell Cancer Research laboratories (DRMCRL), which has an international reputation for its basic and translational research in breast cancer and androgen receptor signaling. My current research aims to explore the exciting potential of Enobosarm, a selective androgen receptor modulator (SARM) in the treatment of endocrine resistant ERα positive breast cancer using contemporary in-vivo and in-vitro experimental models.
During my PhD training at The University of Sydney, I successfully demonstrate the role of protein phosphatase 2A (PP2A) in respiratory epithelia cells and reveal that enhancing the power of endogenous PP2A can be an effective and alternative therapeutic approach to combat asthmatic inflammation.
Since 1st March 2016, I have been working at the Dame Roma Mitchell Cancer Research laboratories (DRMCRL), which has an international reputation for its basic and translational research in breast cancer and androgen receptor signaling. My current research aims to explore the exciting potential of Enobosarm, a selective androgen receptor modulator (SARM) in the treatment of endocrine resistant ERα positive breast cancer using contemporary in-vivo and in-vitro experimental models.
During my PhD training at The University of Sydney, I successfully demonstrate the role of protein phosphatase 2A (PP2A) in respiratory epithelia cells and reveal that enhancing the power of endogenous PP2A can be an effective and alternative therapeutic approach to combat asthmatic inflammation.
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Appointments
Date Position Institution name 2016 - ongoing Postdoctoral Research Fellow University of Adelaide 2013 - 2015 Casual Academic Staff University of Sydney 2012 - 2016 Postgraduate Researcher (specialization in Molecular Biology) University of Sydney 2011 - ongoing Assistant Professor (on extraordinary leave) Stamford University Bangladesh 2008 - 2008 Assistant Proctor Stamford University Bangladesh 2006 - 2011 Lecturer Stamford University Bangladesh 2005 - 2015 Executive (Sales training) Orion Pharma Ltd, Bangladesh -
Awards and Achievements
Date Type Title Institution Name Country Amount 2016 Research Award Postgraduate Research Support Scheme (PRSS) travel grant The University of Sydney Australia — 2012 Scholarship Endeavour Postgraduate award-2012 Australian Government- Department of Education and Training Australia — 2012 Scholarship Internal Faculty Scholarship Faculty of Pharmacy, The University of Sydney Australia — 2008 Scholarship Korean Government Scholarship — Korea, Republic of — 1999 Scholarship University Merit Scholarship Khulna University Bangladesh — -
Language Competencies
Language Competency Bengali Can read, write, speak, understand spoken and peer review English Can read, write, speak, understand spoken and peer review Hindi Can understand spoken Korean Can read, write, speak and understand spoken -
Education
Date Institution name Country Title 2012 - 2016 The University of Sydney Australia Ph.D. 2009 - 2011 Seoul National University Korea, Republic of MSc in Pharmacy 1999 - 2003 Khulna University Bangladesh B.Pharm (Hons) -
Research Interests
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Journals
Year Citation 2019 Tarulli, G., Laven-Law, G., Shehata, M., Walters, K., Denis, I., Rahman, M., . . . Hickey, T. (2019). Androgen receptor signalling promotes a luminal phenotype in mammary epithelial cells. Journal of Mammary Gland Biology and Neoplasia, 24(1), 99-108.
Scopus3 WoS2 Europe PMC12017 Patel, B., Rahman, M., Baehring, G., Xenaki, D., Tang, F. -M., Oliver, B., & Ammit, A. (2017). Roflumilast N-Oxide in Combination with Formoterol Enhances the Antiinflammatory Effect of Dexamethasone in Airway Smooth Muscle Cells. Am J Respir Cell Mol Biol, 56(4), 532-538.
Scopus9 Europe PMC42016 Patel, B., Rahman, M., Rumzhum, N., Oliver, B., Verrills, N., & Ammit, A. (2016). Theophylline represses IL-8 secretion from airway smooth muscle cells independently of phosphodiesterase inhibition: Novel role as a protein phosphatase 2A activator. American Journal of Respiratory Cell and Molecular Biology, 54(6), 792-801.
Scopus10 Europe PMC62016 Rahman, M., Prabhala, P., Rumzhum, N., Patel, B., Wickop, T., Hansbro, P., . . . Ammit, A. (2016). TLR2 ligation induces corticosteroid insensitivity in A549 lung epithelial cells: anti-inflammatory impact of PP2A activators. The International Journal of Biochemistry and Cell Biology, 78, 279-287.
Scopus8 Europe PMC62016 Rahman, M., Prünte, L., Lebender, L., Patel, B., Gelissen, I., Hansbro, P., . . . Ammit, A. (2016). The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells. Scientific Reports, 6(1), 1-8.
Scopus17 Europe PMC122016 Rahman, M., Rumzhum, N., Hansbro, P., Morris, J., Clark, A., Verrills, N., & Ammit, A. (2016). Activating protein phosphatase 2A (PP2A) enhances tristetraprolin (TTP) anti-inflammatory function in A549 lung epithelial cells. Cellular Signalling, 28(4), 325-334.
Scopus31 Europe PMC242016 Patel BS, Rahman MM, Rumzhum NN, Oliver BG, Verrills NM, Ammit AJ.., & Rahman, M. (2016). Theophylline Represses IL-8 Secretion From ASM Cells Independently of PDE Inhibition: Novel Role as a PP2A Activator. Am J Respir Cell Mol Biol, 54(6), 792-801. 2016 Rumzhum, N., Rahman, M., Oliver, B., & Ammit, A. (2016). Effect of Sphingosine 1-Phosphate on Cyclo-Oxygenase-2 Expression, Prostaglandin E2 Secretion, and β2-Adrenergic Receptor Desensitization. Am J Respir Cell Mol Biol., 54(1), 128-135.
Scopus18 Europe PMC122015 Rahman, M., Rumzhum, N., Morris, J., Clark, A., Verrills, N., & Ammit, A. (2015). Basal protein phosphatase 2A activity restrains cytokine expression: role for MAPKs and tristetraprolin. Scientific Reports, 5(1), 10063-1-10063-16.
Scopus25 Europe PMC172015 Prabhala, P., Bunge, K., Rahman, M. M., Ge, Q., Clark, A. R., & Ammit, A. J. (2015). Temporal regulation of cytokine mRNA expression by tristetraprolin: dynamic control by p38 MAPK and MKP-1. American Journal of Physiology: Lung Cellular and Molecular Physiology, 308(9), L973-L980.
Scopus25 Europe PMC192014 Alkhouri, H., Rumzhum, N., Rahman, M., FitzPatrick, M., de Pedro, M., Oliver, B., . . . Ammit, A. (2014). TLR2 activation causes tachyphylaxis to β₂ -agonists in vitro and ex vivo: modelling bacterial exacerbation. Allergy, 69(9), 1215-1222.
Scopus10 Europe PMC72014 Rahman, M., Alkhouri, H., Tang, F., Che, W., Ge, Q., & Ammit, A. (2014). Sphingosine 1-phosphate induces neutrophil chemoattractant IL-8: repression by steroids. PLoS One, 9(3), e92466-1-e92466-8.
Scopus21 Europe PMC182013 Hirota, J. A., Im, H., Rahman, M. M., Rumzhum, N. N., Manetsch, M., Pascoe, C. D., . . . Ammit, A. J. (2013). The nucleotide-binding domain and leucine-rich repeat protein-3 inflammasome is not activated in airway smooth muscle upon toll-like receptor-2 ligation. American Journal of Respiratory Cell and Molecular Biology, 49(4), 517-524.
Scopus5 Europe PMC52013 Manetsch, M., Rahman, M., Patel, B., Ramsay, E., Rumzhum, N., Alkhouri, H., . . . Ammit, A. (2013). Long-acting β2-agonists increase fluticasone propionate-induced mitogen-activated protein kinase phosphatase 1 (MKP-1) in airway smooth muscle cells. PLoS One, 8(3), e59635-1-e59635-9.
Scopus29 Europe PMC212012 Che, W., Manetsch, M., Quante, T., Rahman, M., Patel, B., Ge, Q., & Ammit, A. (2012). Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells. Biochimica et Biophysica Acta-Molecular Cell Research, 1823(10), 1658-1665.
Scopus34 Europe PMC272011 Rahman, M., Kundu, J., Shin, J., Na, H., & Surh, Y. (2011). Docosahexaenoic acid inhibits UVB-induced activation of NF-κB and expression of COX-2 and NOX-4 in HR-1 hairless mouse skin by blocking MSK1 signaling. PLoS One, 6(11), 1-10.
2007 Ahmed, F., Shahid, I. Z., Rahman, M. M., Masud, M. M., & Sadhu, S. K. (2007). Antinociceptive activity of Derris uliginosa. Fitoterapia, 78(5), 377-378.
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Memberships
Date Role Membership Country 2016 - ongoing Member Australia Alumni association Bangladesh Bangladesh 2016 - ongoing Member Alumni The University of Sydney Australia 2016 - ongoing Member Australian Government scholarship alumni Australia 2014 - ongoing Member American Association for Pharmaceutical Scientists (AAPS) Australia 2013 - ongoing Member Australian Society for Medical Research — 2011 - ongoing Member Alumni Korean Government Scholarship Program Korea, Republic of 2011 - ongoing Member Alumni Seoul National University — 2006 - ongoing Member Pharmacist, registration Number A-2721 Bangladesh 2005 - ongoing Member Alumni Khulna University Bangladesh
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