Dr Iza Denis

Iza Denis
Research Fellow - DRMCRL
Adelaide Medical School
Faculty of Health and Medical Sciences

Dr Iza Denis is a National Breast Cancer Foundation of Australia Fellow at the Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide. In 2009 Dr Denis completed a Bachelor in Life and Earth Sciences at the University of Rennes, France. In 2009, she undertook a Master’s program in Regenerative Medicine (funded by an ERASMUS scholarship) at the DNA damage response laboratory, National University of Galway Ireland (NUIG). Her research project was focused on elucidating cytoplasmic and nuclear signalling in response to chemotherapeutic drugs in human breast cancer cells. Dr Denis subsequently (2010) undertook an additional MSc program in Cellular Biology and Physiopathology at the University Victor Segalen of Bordeaux, France, during which she studied the role of the CXCL4 chemokine and a CXCL4 variant, CXCL4L1, in cancer-related angiogenesis. In 2014 she was awarded her PhD at the University of Nantes Cancer Research Institute, France. The focus of her PhD studies was developing new therapeutic approaches to treat mesothelioma and lung cancer, utilising nanomedicine, new epigenetic drugs and immunogenic strategies. Dr Denis has published 8 original research papers (4 as first author).

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Dr Iza Denis

Dr Iza Denis is a National Breast Cancer Foundation of Australia Fellow at the Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide. In 2009 Dr Denis completed a Bachelor in Life and Earth Sciences at the University of Rennes, France. In 2009, she undertook a Master’s program in Regenerative Medicine (funded by an ERASMUS scholarship) at the DNA damage response laboratory, National University of Galway Ireland (NUIG). Her research project was focused on elucidating cytoplasmic and nuclear signalling in response to chemotherapeutic drugs in human breast cancer cells. Dr Denis subsequently (2010) undertook an additional MSc program in Cellular Biology and Physiopathology at the University Victor Segalen of Bordeaux, France, during which she studied the role of the CXCL4 chemokine and a CXCL4 variant, CXCL4L1, in cancer-related angiogenesis. In 2014 she was awarded her PhD at the University of Nantes Cancer Research Institute, France. The focus of her PhD studies was developing new therapeutic approaches to treat mesothelioma and lung cancer, utilising nanomedicine, new epigenetic drugs and immunogenic strategies. Dr Denis has published 8 original research papers (4 as first author).

Journals

Date Citation
2017 Das,R, Gregory,PA, Fernandes,RC, Denis,I, Wang,Q, Townley,SL, Zhao,SG, Hanson,A, Pickering,MA, Armstrong,HK et al, 2017, MicroRNA-194 promotes prostate cancer metastasis by inhibiting SOCS2., Cancer Res, 77, 4, - 10.1158/0008-5472.CAN-16-2529
2016 Bahhaj,FE, Denis,I, Pichavant,L, Delatouche,R, Collette,F, Linot,C, Pouliquen,D, Grégoire,M, Héroguez,V, Blanquart,C et al, 2016, Histone Deacetylase Inhibitors Delivery using Nanoparticles with Intrinsic Passive Tumor Targeting Properties for Tumor Therapy, Theranostics, 6, 6, 795-807 10.7150/thno.13725
2015 Denis,I, el Bahhaj,F, Collette,F, Delatouche,R, Gueugnon,F, Pouliquen,D, Pichavant,L, Héroguez,V, Grégoire,M, Bertrand,P et al, 2015, Histone deacetylase inhibitor-polymer conjugate nanoparticles for acid-responsive drug delivery, European Journal of Medicinal Chemistry, 95, 369-376 10.1016/j.ejmech.2015.03.037
2014 Denis,I, el Bahhaj,F, Collette,F, Delatouche,R, Gueugnon,F, Pouliquen,D, Pichavant,L, Héroguez,V, Grégoire,M, Bertrand,P et al, 2014, Vorinostat–Polymer Conjugate Nanoparticles for Acid-Responsive Delivery and Passive Tumor Targeting, Biomacromolecules, 15, 12, 4534-4543 10.1021/bm501338r
2014 Zwick,V, Chatzivasileiou,AO, Deschamps,N, Roussaki,M, Simões-Pires,CA, Nurisso,A, Denis,I, Blanquart,C, Martinet,N, Carrupt,PA et al, 2014, Aurones as histone deacetylase inhibitors: Identification of key features, Bioorganic & Medicinal Chemistry Letters, 24, 23, 5497-5501 10.1016/j.bmcl.2014.10.019
2014 Denis,I, Cellerin,L, Gregoire,M, Blanquart,C, 2014, Cisplatin in combination with Phenethyl Isothiocyanate (PEITC), a potential new therapeutic strategy for malignant pleural mesothelioma, Oncotarget, 5, 22, 11641-11652 10.18632/oncotarget.2604
2013 Gueugnon,F, Denis,I, Pouliquen,D, Collette,F, Delatouche,R, Héroguez,V, Grégoire,M, Bertrand,P, Blanquart,C, 2013, Nanoparticles Produced by Ring-Opening Metathesis Polymerization Using Norbornenyl-poly(ethylene oxide) as a Ligand-Free Generic Platform for Highly Selective In Vivo Tumor Targeting, Biomacromolecules, 14, 7, 2396-2402 10.1021/bm400516b
2013 Delatouche,R, Denis,I, Grinda,M, Bahhaj,FE, Baucher,E, Collette,F, Héroguez,V, Grégoire,M, Blanquart,C, Bertrand,P et al, 2013, Design of pH responsive clickable prodrugs applied to histone deacetylase inhibitors: A new strategy for anticancer therapy, European Journal of Pharmaceutics and Biopharmaceutics, 85, 3, 862-872 10.1016/j.ejpb.2013.03.006
Position
Research Fellow - DRMCRL
Phone
7623240
Fax
8222 3217
Campus
Institute of Medical & Veterinary Science
Building
IMVS - Hanson Institute Building
Org Unit
School of Medicine

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