Dr Ian Musgrave
Senior Lecturer
School of Biomedicine
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
I am a molecular pharmacologist who works at the University of Adelaide, Australia. I have a broad interest in the understanding of how surface receptors can modulate neuronal function and survival, as well as interests in natural product pharmacology and toxicology as well as drug design. I am also interested in evolutionary biology, science communication (committee member of SA Science Communicators). I write for the Conversation on the toxicological impacts of everyday items. I am also an avid amateur astronomer. My astronomy blog is astroblog.
I did postdoctoral work in the Institute of Pharmacology at the Free University of Berlin in 1991-1994, returning to Australia in 1994. I have collaborated with Professor John Carver, Dr. Scot Smid and Professor Colin Barrow on using natural products to attack the neurodegeneration process in Alzheimer’s Disease. I am currently the convenor of the Toxicology Special Interest Group of the Australasian Society for Pharmacology and Toxicology. I am also collaborating with Professor Roger Byard on the forensic implications of herbal medicines. I have held NH&MRC funding and ARC funding.
- My Research
- Career
- Publications
- Grants and Funding
- Teaching
- Supervision
- Professional Activities
- Contact
The main thrust of my research has been the role of signal transduction in neuronal function. In recent years this has extended into the area of neuroprotection and neurotoxicity. This has been followed on three fronts; the role of amyloid peptides in neurotoxicity, and how this may be combated with natural products. This work is undertaken with Professor John Carver and Dr. Scott Smid. We have found potent products that can prevent and disrupt amyloid formation. This has profound implications not only for the therapy of Alzhemiers' disease but for a wide range of diseases that involve protein misfolding, from systemic amyloidosis to HIV infection. As a further logical development of the natural product theme, my work has branched out into neurotoxicology with work with Professor Roger Byard and Professor Michael Bunce (Curtin University WA) looking at the toxicity of herbal medicines. (NHMRC Grant APP1061329) As a result of this work we have collaborated with the TGA and the South Australian Health Department have been able to advise them of potentially dangerous herbal medicines.
Project 1.
Title: Exploring the herbal phytochemical Bakuchiol's Toxicity
Project outline: Psoralea corylifolia, or Bu Gu Zhi in Traditional Chinese Medicine, is associated with hepatotoxicity. Psoralea corylifolia contains a number of phytochemicals: Psoralen, isopsoralen and Bakuchiol been associated with hepatotoxicity (but see DOI: 10.4268/cjcmm20151129). Preliminary experiments from our lab have shown that Bakuchiol to be more toxic than Psoralen to the hepatocyte model cell line HepG2. Given its use in cosmetics, the effect of Bakuchiol on toxicity in an epithelial cell line will be tested as well. Cell viability will be determined via MTT and epithelial barrier integrity will be determined via TEER. As well as pure Bakuchiol, commercial preparations of Bakuchiol will be tested for toxicity, as the supporting ingredients may alter Bakuchiol toxicity.
Project available for Honours and potentially HDR.
Location: North Terrace campus, Helen Mayo South
Project 2.
Title: The evolving usage of Herbal medicines in Australia post COVID
Project outline: During the COVID-19 pandemic, herbal medicines were promoted as therapies. However, we do not know the pattern of usage of herbal medicines during or after the pandemic. The last survey of Herbal use in Australia dates back to 2008 (pharmacoepidemiology and drug safety 2008; 17: 1006–1013DOI: 10.1002/pds.1610). Furthermore, we do not know if the patterns of use of herbal medicine had an impact on adverse drug reactions. To address this this project will have two parts.
a) Developing and Administering a population-based survey on herbal medicine use during the years 2020-2022 (requires human ethics approval).
b) Searching the TGA Adverse drug reactions database to look at ADR reporting of these common herbal medicines pre-pandemic and during the pandemic. And determine if there is an increase in ADR’s during this pandemic period.
Project available for Honours and potentially HDR.
Location: North Terrace campus, Helen Mayo South
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Appointments
Date Position Institution name 2001 - ongoing Senior Lecturer University of Adelaide 1998 - 2000 Senior Research Officer Royal Melbourne Institute of Technology University 1997 - ongoing Research Fellow (Wholetime Medical Specialists) Prince Henry’s Institute of Medical Research 1995 - 1996 Research Fellow (National Health and Medical Research Council C.J. Martin) Prince Henry's Institute of Medical Research 1992 - 1994 Research Fellow (National Health and Medical Research Council C.J. Martin) Institut für Molekulare Pharmakologie (LG), Freie Universität 1991 - 1992 Alexander von Humboldt Fellow Institut für Molekulare Pharmakologie (LG), Freie Universität 1989 - 1991 National Health and Medical Research Council Research Officer Department of Pharmacology 1985 - ongoing Research Assistant I University of Queensland 1980 - 1984 Research Assistant II University of Queensland 1977 - 1980 Technologist B University of Queensland -
Awards and Achievements
Date Type Title Institution Name Country Amount 2018 Achievement The Thornett Award for the Promotion of Reason 2018 Australian Skeptics Australia $2000 2017 Recognition Unsung hero of Science Communication SA 2017 Government of South Australia, Department of Industry and Skills Australia - 1995 Research Award Johnson and Johnson New Investigator Award Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Australia - -
Language Competencies
Language Competency German Can read, speak and understand spoken -
Education
Date Institution name Country Title 1989 University of Melbourne Australia Ph.D. 1987 University of Queensland Australia M. Sc. 1976 Queensland Institute of Technology Australia B.App.Sci. -
Research Interests
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Journals
Year Citation 2023 He, Y., Ketagoda, D. H. K., Bright, R., Britza, S. M., Zechner, J., Musgrave, I., . . . Zilm, P. (2023). Synthesis of Cationic Silver Nanoparticles with Highly Potent Properties against Oral Pathogens and Their Biofilms. ChemNanoMat, 9(3), 1-8.
Scopus3 WoS22022 Zechner, J., Britza, S. M., Farrington, R., Byard, R. W., & Musgrave, I. F. (2022). Flavonoid-statin interactions causing myopathy and the possible significance of OATP transport, CYP450 metabolism and mevalonate synthesis.. Life Sci, 291, 8 pages.
Scopus9 WoS3 Europe PMC12022 Tennakoon, A., Katharesan, V., Musgrave, I. F., Koblar, S. A., Faull, R. L. M., Curtis, M. A., & Johnson, I. P. (2022). Normal aging, motor neurone disease, and Alzheimer’s disease are characterized by cortical changes in inflammatory cytokines. Journal of Neuroscience Research, 100(2), 653-669.
Scopus10 WoS8 Europe PMC62022 Britza, S. M., Musgrave, I. F., Farrington, R., & Byard, R. W. (2022). Intestinal epithelial damage due to herbal compounds - an in vitro study.. Drug Chem Toxicol, 46(2), 1-9.
Scopus2 WoS1 Europe PMC12022 Britza, S. M., Musgrave, I. F., & Byard, R. W. (2022). Implications for herbal polypharmacy: coumarin-induced hepatotoxicity increased through common herbal phytochemicals astragaloside IV and atractylenolide I.. Toxicology mechanisms and methods, 32(8), 1-10.
Scopus3 WoS2 Europe PMC12022 Britza, S. M., Farrington, R., Byard, R. W., & Musgrave, I. F. (2022). In vitro demonstration of herbal exacerbation of paracetamol-induced hepatotoxicity. Phytomedicine Plus, 2(2), 1-9.
Scopus32022 Britza, S. M., Byard, R. W., & Musgrave, I. F. (2022). Traditional Chinese medicine-associated nephrotoxicity and the importance of herbal interactions – an overview. Pharmacological Research - Modern Chinese Medicine, 3, 1-6.
Scopus62022 Britza, S. M., Farrington, R., Musgrave, I. F., Aboltins, C., & Byard, R. W. (2022). Could herbal soup be a potentially unrecognized cause of hepatotoxicity at autopsy?. Forensic science, medicine, and pathology, 18(4), 403-406.
Scopus4 WoS32022 Elias, A. K., Wilson, M. R., Carver, J. A., & Musgrave, I. F. (2022). The Extracellular Molecular Chaperone Clusterin Inhibits Amyloid Fibril Formation and Suppresses Cytotoxicity Associated with Semen-Derived Enhancer of Virus Infection (SEVI). Cells, 11(20), 3259-1-3259-12.
Scopus2 WoS1 Europe PMC12022 Britza, S. M., Farrington, R., Musgrave, I. F., & Byard, R. W. (2022). Does Bak Kut Teh really cause hepatotoxicity?. Forensic science, medicine, and pathology, 19(1), 133-134.
Europe PMC12021 Byard, R. W., & Musgrave, I. F. (2021). Does herbal therapy for COVID-19 have implications for forensic practice?. Forensic science, medicine, and pathology, 17(3), 377-378.
Scopus2 WoS12021 Ngo, S., White, P. J., Davis, E. A., Santiago, M., Angelo, T., Shield, A., . . . Hinton,, T. (2021). Identifying the core concepts of pharmacology education. Pharmacology Research and Perspectives, 9(4), e00836-1-e00836-13.
Scopus12 WoS8 Europe PMC42021 Byard, R. W., & Musgrave, I. (2021). The potential side effects of herbal preparations in domestic animals. Forensic Science, Medicine, and Pathology, 17(4), 723-725.
Scopus32021 Santiago, M., Davis, E. A., Hinton, T., Angelo, T. A., Shield, A., Babey, A. M., . . . White, P. J. (2021). Defining and unpacking the core concepts of pharmacology education. Pharmacology Research and Perspectives, 9(6), e00894-1-e00894-9.
Scopus13 WoS9 Europe PMC52020 Hoban, C. L., Musgrave, I. F., Byard, R. W., Nash, C., Farrington, R., Maker, G., . . . Coghlan, M. (2020). Combined liquid chromatography-mass spectrometry and next-generation dna sequencing detection of adulterants and contaminants in analgesic and anti-inflammatory herbal medicines. Pharmaceutical Medicine, 34(1), 49-61.
Scopus11 WoS5 Europe PMC12020 Britza, S. M., Musgrave, I. F., & Byard, R. W. (2020). Paracetamol (acetaminophen) hepatotoxicity increases in the presence of an added herbal compound. Legal Medicine, 47, 3 pages.
Scopus12 WoS9 Europe PMC42019 Farrington, R., Musgrave, I., Nash, C., Coghlan, M., & Byard, R. (2019). Evaluation of an early twentieth century Afghan herbalist’s preparations. Forensic Science, Medicine, and Pathology, 15(2), 314-318.
Scopus1 WoS1 Europe PMC12019 Farrington, R., Musgrave, I., & Byard, R. W. (2019). Potential adverse outcomes of herbal preparation use in childhood. Acta Paediatrica, International Journal of Paediatrics, 108(3), 419-422.
Scopus10 WoS6 Europe PMC32019 Alghazwi, M., Smid, S., Musgrave, I., & Zhang, W. (2019). In vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Aβ₁−₄₂) toxicity and aggregation. Neurochemistry International, 124, 215-224.
Scopus72 WoS66 Europe PMC402019 Farrington, R., Musgrave, I. F., & Byard, R. W. (2019). Evidence for the efficacy and safety of herbal weight loss preparations. Journal of integrative medicine, 17(2), 87-92.
Scopus22 WoS19 Europe PMC62019 Hoban, C. L., Byard, R. W., & Musgrave, I. F. (2019). Analysis of spontaneous adverse drug reactions to echinacea, valerian, black cohosh and ginkgo in Australia from 2000 to 2015. JOURNAL OF INTEGRATIVE MEDICINE-JIM, 17(5), 338-343.
Scopus9 WoS7 Europe PMC52019 Crighton, E., Weisenseel, J., Bunce, M., Musgrave, I. F., Trengove, R., & Maker, G. (2019). Exploring the application of the DSA-TOF, a direct, high-resolution time-of-flight mass spectrometry technique for the screening of potential adulterated and contaminated herbal medicines. Journal of the American Society for Mass Spectrometry, 30(9), 1713-1719.
Scopus10 WoS6 Europe PMC32019 Crighton, E., Coghlan, M., Farrington, R., Hoban, C., Power, M., Nash, C., . . . Maker, G. (2019). Toxicological screening and DNA sequencing detects contamination and adulteration in regulated herbal medicines and supplements for diet, weight loss and cardiovascular health. Journal of Pharmaceutical and Biomedical Analysis, 176, 112834-1-112834-7.
Scopus20 WoS16 Europe PMC52019 Sun, B., Sundaraneedi, M. K., Southam, H. M., Poole, R. K., Musgrave, I. F., Keene, F. R., & Collins, J. G. (2019). Synthesis and biological properties of tetranuclear ruthenium complexes containing the bis[4(4'-methyl-2,2'-bipyridyl)]-1,7-heptane ligand.. Dalton transactions (Cambridge, England : 2003), 48(38), 14505-14515.
Scopus13 WoS11 Europe PMC32019 Hoban, C., Byard, R., & Musgrave, I. (2019). Hypersensitive adverse drug reactions to glucosamine and chondroitin preparations in Australia between 2000 and 2011.. Postgraduate medical journal, 96(1134), 190-193.
Scopus4 WoS2 Europe PMC12018 Hoban, C. L., Musgrave, I. F., Coghlan, M. L., Power, M. W. P., Byard, R. W., Nash, C., . . . Bunce, M. (2018). Adulterants and Contaminants in Psychotropic Herbal Medicines Detected with Mass Spectrometry and Next-Generation DNA Sequencing. Pharmaceutical Medicine, 32(6), 429-444.
Scopus17 WoS102018 Sun, B., Musgrave, I., Day, A., Heimann, K., Keene, F., & Collins, J. (2018). Eukaryotic cell toxicity and HSA binding of [Ru(Me <inf>4</inf> phen)(bb <inf>7</inf> )] <sup>2+</sup> and the effect of encapsulation in cucurbit[10]uril. Frontiers in Chemistry, 6(NOV), 12 pages.
Scopus7 WoS8 Europe PMC12018 Pilla, M., van den Heuvel, C., Musgrave, I., & Byard, R. W. (2018). Increasing incidence of nonlethal inflicted injuries in paediatric homicides: a 45-year study. Journal of Forensic and Legal Medicine, 59, 4-7.
Scopus2 WoS12018 Farrington, R., Musgrave, I., Nash, C., & Byard, R. W. (2018). Potential forensic issues in overseas travellers exposed to local herbal products. Journal of Forensic and Legal Medicine, 60, 1-2.
Scopus10 WoS8 Europe PMC12018 Hoban, C., Nash, C., Musgrave, I. F., & Byard, R. W. (2018). An analysis of Vietnamese traditional herbal medicines for prescription and non-prescription drugs, herbicides and pesticides. Australian Journal of Forensic Sciences, 50(5), 514-520.
Scopus3 WoS32017 Byard, R., Musgrave, I., Maker, G., & Bunce, M. (2017). What risks do herbal products pose to the Australian community?. Medical Journal of Australia, 206(2), 86-90.
Scopus57 WoS43 Europe PMC172017 O'Neill, K., Musgrave, I. F., & Humpage, A. (2017). Extended Low-Dose Exposure to Saxitoxin Inhibits Neurite Outgrowth in Model Neuronal Cells. Basic and Clinical Pharmacology and Toxicology, 120(4), 390-397.
Scopus11 WoS8 Europe PMC52016 Das, S., Stark, L., Musgrave, I., Pukala, T., & Smid, S. (2016). Bioactive polyphenol interactions with β amyloid: a comparison of binding modelling, effects on fibril and aggregate formation and neuroprotective capacity. Food & Function, 7(2), 1138-1146.
Scopus42 WoS39 Europe PMC152016 Maiden, N., Musgrave, I., Fisk, W., & Byard, R. (2016). Pig Organ Energy Loss Comparison Experiments Using BBs. Journal of Forensic Sciences, 61(3), 679-686.
Scopus6 WoS6 Europe PMC32016 Jayne, T., Newman, M., Verdile, G., Sutherland, G., Münch, G., Musgrave, I., . . . Lardelli, M. (2016). Evidence for and against a pathogenic role of reduced γ-secretase activity in familial Alzheimer's disease. Journal of Alzheimer's Disease, 52(3), 781-799.
Scopus32 WoS27 Europe PMC252016 Musgrave, I., Farrington, R., Hoban, C., & Byard, R. (2016). Caffeine toxicity in forensic practice: possible effects and under-appreciated sources. Forensic Science, Medicine, and Pathology, 12(3), 299-303.
Scopus25 WoS19 Europe PMC102016 Gransbury, G., Kappen, P., Glover, C., Hughes, J., Levina, A., Lay, P., . . . Harris, H. (2016). Comparison of KP1019 and NAMI-A in tumour-mimetic environments. Metallomics, 8(8), 762-773.
Scopus36 WoS34 Europe PMC92016 Brinn, M., O'Neill, K., Musgrave, I., Freeman, B., Henneberg, M., & Kumaratilake, J. (2016). An optimized method for obtaining adult rat spinal cord motor neurons to be used for tissue culture. Journal of Neuroscience Methods, 273, 128-137.
Scopus12016 O'Neill, K., Musgrave, I., & Humpage, A. (2016). Low dose extended exposure to saxitoxin and its potential neurodevelopmental effects: A review. Environmental Toxicology and Pharmacology, 48, 7-16.
Scopus39 WoS31 Europe PMC122016 Calabrese, A., Liu, Y., Wang, T., Musgrave, I., Pukala, T., Tabor, R., . . . Bowie, J. (2016). The amyloid fibril-forming properties of the amphibian antimicrobial peptide uperin 3.5. ChemBioChem, 17(3), 239-246.
Scopus36 WoS34 Europe PMC172015 Coghlan, M., Maker, G., Crighton, E., Haile, J., Murray, D., White, N., . . . Bunce, M. (2015). Combined DNA, toxicological and heavy metal analyses provides an auditing toolkit to improve pharmacovigilance of traditional Chinese medicine (TCM). Scientific Reports, 5(1), 17475-1-17475-9.
Scopus88 WoS69 Europe PMC402015 Moussavi Nik, S., Newman, M., Wilson, L., Ebrahimie, E., Wells, S., Musgrave, I., . . . Lardelli, M. (2015). Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity. Human Molecular Genetics, 24(13), 3662-3678.
Scopus25 WoS22 Europe PMC142015 Hoban, C., Byard, R., & Musgrave, I. (2015). A comparison of patterns of spontaneous adverse drug reaction reporting with St. John's Wort and fluoxetine during the period 2000-2013. Clinical and Experimental Pharmacology and Physiology, 42(7), 747-751.
Scopus20 WoS14 Europe PMC82014 Gilbert, J., Musgrave, I., Hoban, C., & Byard, R. (2014). Lethal hepatocellular necrosis associated with herbal polypharmacy in a patient with chronic hepatitis B infection. Forensic Science International, 241, 138-140.
Scopus18 WoS14 Europe PMC32014 Elias, A., Scanlon, D., Musgrave, I., & Carver, J. (2014). SEVI, the semen enhancer of HIV infection along with fragments from its central region, form amyloid fibrils that are toxic to neuronal cells. Biochimica et Biophysica Acta - Proteins and Proteomics, 1844(9), 1591-1598.
Scopus16 WoS14 Europe PMC102014 Blacksell, L., Byard, R., & Musgrave, I. (2014). Forensic problems with the composition and content of herbal medicines. Journal of Forensic and Legal Medicine, 23, 19-21.
Scopus13 WoS8 Europe PMC32014 Byard, R. W., Musgrave, I., Hoban, C., & Bunce, M. (2014). DNA sequencing and metabolomics: new approaches to the forensic assessment of herbal therapeutic agents. Forensic Science, Medicine, and Pathology, 11(1), 1-2.
Scopus9 WoS6 Europe PMC32014 Liu, Y., Carver, J., Ho, L., Elias, A., Musgrave, I., & Pukala, T. (2014). Hemin as a generic and potent protein misfolding inhibitor. Biochemical and Biophysical Research Communications, 454(2), 295-300.
Scopus21 WoS19 Europe PMC82013 Lloyd, H., Hinton, T., Bullock, S., Babey, A., Davis, E., Fernandes, L., . . . Ziogas, J. (2013). An evaluation of pharmacology curricula in Australian science and health-related degree programs. BMC Medical Education, 13(1), 1-15.
Scopus13 WoS12 Europe PMC62013 Liu, Y., Pukala, T., Musgrave, I., Williams, D., Dehle, F., & Carver, J. (2013). Gallic acid is the major component of grape seed extract that inhibits amyloid fibril formation. Bioorganic & Medicinal Chemistry Letters, 23(23), 6336-6340.
Scopus100 WoS95 Europe PMC432013 Wong, D., Musgrave, I., Harvey, B., & Smid, S. (2013). Açaí (Euterpe oleraceae Mart.) berry extract exerts neuroprotective effects against β-amyloid exposure in vitro. Neuroscience Letters, 556, 221-226.
Scopus45 WoS38 Europe PMC242013 Rahman, S., Basilakis, J., Rahmadi, A., Lujic, S., Musgrave, I., Jorm, L., . . . Munch, G. (2013). Use of serotonergic antidepressants and St John's wort in older Australians: A population-based cohort study. Australasian Psychiatry, 21(3), 262-266.
Scopus6 WoS4 Europe PMC32012 Calabrese, A., Markulic, K., Musgrave, I., Guo, H., Zhang, L., & Bowie, J. (2012). Structural and activity changes in three bioactive anuran peptides when Asp is replaced by isoAsp. Peptides, 38(2), 427-436.
Scopus1 WoS1 Europe PMC12012 Smid, S., Maag, J., & Musgrave, I. (2012). Dietary polyphenol-derived protection against neurotoxic β-amyloid protein: from molecular to clinical. Food & Function: linking the chemistry and physics of food with health and nutrition, 3(12), 1242-1250.
Scopus55 WoS47 Europe PMC212012 Koudelka, T., Dehle, F., Musgrave, I., Hoffmann, P., & Carver, J. (2012). Methionine oxidation enhances κ-casein amyloid fibril formation. Journal of Agricultural and Food Chemistry, 60(16), 4144-4155.
Scopus28 WoS27 Europe PMC112012 Weekley, C., Aitken, J., Musgrave, I., & Harris, H. (2012). Methylselenocysteine treatment leads to diselenide formation in human cancer cells: evidence from X-ray absorption spectroscopy studies. Biochemistry, 51(3), 736-738.
Scopus23 WoS20 Europe PMC112012 Moussavi Nik, S., Wilson, L., Newman, M., Croft, K., Mori, T., Musgrave, I., & Lardelli, M. (2012). The BACE1-PSEN-AβPP regulatory axis has an ancient role in response to low oxygen/oxidative stress. Journal of Alzheimer's Disease, 28(3), 515-530.
Scopus44 WoS23 Europe PMC272012 Harvey, B., Ohlsson, K., Maag, J., Musgrave, I., & Smid, S. (2012). Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro. Neurotoxicology, 33(1), 138-146.
Scopus64 WoS57 Europe PMC402012 Wilkins, J., Stanyon, C., & Musgrave, I. (2012). Selection without replicators: the origin of genes, and the replicator/interactor distinction in etiobiology. Biology & Philosophy, 27(2), 215-239.
Scopus4 WoS32011 Weekley, C., Aitken, J., Vogt, S., Finney, L., Paterson, D., De Jonge, M., . . . Harris, H. (2011). Metabolism of selenite in human lung cancer cells: X-ray absorption and fluorescence studies. Journal of the American Chemical Society, 133(45), 18272-18279.
Scopus73 WoS68 Europe PMC342011 Harvey, B., Musgrave, I., Ohlsson, K., Fransson, A., & Smid, S. (2011). The green tea polyphenol (−)-epigallocatechin-3-gallate inhibits amyloid-β evoked fibril formation and neuronal cell death in vitro. Food Chemistry, 129(4), 1729-1736.
Scopus39 WoS34 Europe PMC172011 Weekley, C., Aitken, J., Vogt, S., Finney, L., Paterson, D., De Jonge, M., . . . Harris, H. (2011). Uptake, distribution, and speciation of selenoamino acids by human cancer cells: X-ray absorption and fluorescence methods. Biochemistry, 50(10), 1641-1650.
Scopus48 WoS41 Europe PMC282011 Ellis-Steinborner, S., Scanlon, D., Musgrave, I., Tran, T., Hack, S., Wang, T., . . . Bowie, J. (2011). An unusual kynurenine-containing opioid tetrapeptide from the skin gland secretion of the Australian red tree frog Litoria rubella. Sequence determination by electrospray mass spectrometry. Rapid Communications in Mass Spectrometry, 25(12), 1735-1740.
Scopus9 WoS10 Europe PMC62011 Lyachev, A., Musgrave, I. O., Tang, Y., Hernandez-Gomez, C., Ross, I. N., Galimberti, M., . . . Collier, J. (2011). Development of a novel large bandwidth front-end system for high peak power OPCPA systems. OPTICS EXPRESS, 19(17), 15824-15832.
WoS15 Europe PMC22010 Dehle, F., Ecroyd, H., Musgrave, I., & Carver, J. (2010). αB-Crystallin inhibits the cell toxicity associated with amyloid fibril formation by κ-casein and the amyloid-β peptide. Cell Stress & Chaperones, 15(6), 1013-1026.
Scopus59 WoS55 Europe PMC292010 Byard, R., & Musgrave, I. (2010). Herbal medicines and forensic investigations. Forensic Science, Medicine, and Pathology, 6(2), 81-82.
Scopus21 WoS16 Europe PMC82010 Ingman, W., McGrath, L., Breed, W., Musgrave, I., Robker, R., & Robertson, S. (2010). The mechanistic basis for sexual dysfunction in male transforming growth factor β1 null mutant mice. Journal of Andrology, 31(2), 95-107.
Scopus5 WoS6 Europe PMC42009 Hudson, S., Ecroyd, H., Dehle, F., Musgrave, I., & Carver, J. (2009). (-)-Epigallocatechin-3-gallate (EGCG) Maintains k-Casein in its pre-fibrillar state without redirecting its aggregation pathway. Journal of Molecular Biology, 392(3), 689-700.
Scopus129 WoS121 Europe PMC662009 Bilusich, D., Jackway, R., Musgrave, I., Tyler, M., & Bowie, J. (2009). The host-defence skin peptide profiles of Peron's Tree Frog Litoria peronii in winter and summer. Sequence determination by electrospray mass spectrometry and activities of the peptides. Rapid Communications in Mass Spectrometry, 23(17), 2628-2636.
Scopus14 WoS13 Europe PMC82009 Sherman, P., Jackway, R., Nicholson, E., Musgrave, I., Boontheung, P., & Bowie, J. (2009). Activities of seasonably variable caerulein and rothein skin peptides from the tree frogs Litoria splendida and Litoria rothii. Toxicon, 54(6), 828-835.
Scopus14 WoS11 Europe PMC52009 Jackway, R., Maselli, V., Musgrave, I., Maclean, M., Tyler, M., & Bowie, J. (2009). Skin peptides from anurans of the Litoria rubella Group: sequence determination using electrospray mass spectrometry. Opioid activity of two major peptides. Rapid Communications in Mass Spectrometry, 23(8), 1189-1195.
Scopus13 WoS13 Europe PMC62008 Jackway, R., Pukala, T., Maselli, V., Musgrave, I., Bowie, J., Liu, Y., . . . Tyler, M. (2008). Disulfide-containing peptides from the glandular skin secretions of froglets of the genus Crinia: Structure, activity and evolutionary trends. Regulatory Peptides, 151(1-3), 80-87.
Scopus10 WoS10 Europe PMC62008 Jackway, R., Bowie, J., Bilusich, D., Musgrave, I., Surinya, K., Tyler, M., & Eichinger, P. (2008). The fallaxidin peptides from the skin secretion of the Eastern Dwarf Tree Frog Litoria fallax. Sequence determination by positive and negative ion electrospray mass spectrometry: antimicrobial activity and cDNA cloning of the fallaxidins. Rapid Communications in Mass Spectrometry, 22(20), 3207-3216.
Scopus13 WoS12 Europe PMC62008 Musgrave, I. (2008). Moth myths. New Scientist, 197(2638), 19.
2007 Newman, M., Musgrave, I., & Lardelli, M. (2007). Alzheimer disease: amyloidogenesis, the presenilins and animal models. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1772(3), 285-297.
Scopus115 WoS103 Europe PMC662007 Newman, M., Musgrave, I. F., & Lardelli, M. (2007). Corrigendum to "Alzheimer disease: Amyloidogenesis, the presenilins and animal models" [Biochim. Biophys. Acta 1772 (2007) 285-297] (DOI:10.1016/j.bbadis.2006.12.001). Biochimica et Biophysica Acta - Molecular Basis of Disease, 1772(9), 1118.
2006 Pukala, T., Bowie, J., Maselli, V., Musgrave, I., & Tyler, M. (2006). Host-defence peptides from the glandular secretions of amphibians: structure and activity. Natural Product Reports, 23(3), 368-393.
Scopus178 WoS168 Europe PMC1072006 Powell, M., Barnes, N., Bradford, T., Musgrave, I., Wines, B., Cambier, J., & Hogarth, P. (2006). Alteration of the Fc[gamma]RIIa dimer interface affects receptor signaling but not ligand binding. Journal of Immunology, 176(12), 7489-7494.
Scopus31 WoS28 Europe PMC232006 Pukala, T. L., Bowie, J. H., Maselli, V. M., Musgrave, I. F., & Tyler, M. J. (2006). Host‐Defence Peptides from the Glandular Secretions of Amphibians: Structure and Activity. ChemInform, 37(37).
2005 Spier, R., Musgrave, I., Kirk, S., & Callaghan, T. (2005). Unintelligent design [1] (multiple letters). New Scientist, 187(2509), 20. 2005 Baudinette, R., Boontheung, P., Musgrave, I., Wabnitz, P., Maselli, V., Skinner, J., . . . Bowie, J. (2005). An immunomodulator used to protect young in the pouch of the Tammar wallaby, Macropus eugenii. FEBS Journal, 272(2), 433-443.
Scopus19 WoS17 Europe PMC132003 Musgrave, I., Dehle, F., & Piletz, J. (2003). Assembly of PRR-containing receptors on scaffolds: a model for imidazoline I1-receptor action. Annals of the New York Academy of Sciences, 1009(1), 413-418.
Scopus3 WoS2 Europe PMC22003 Musgrave, I., van der Zypp, A., Grigg, M., & Barrow, C. (2003). Endogenous imidazoline receptor ligands relax rat aorta by an endothelium-dependent mechanism. Annals of the New York Academy of Sciences, 1009(1), 222-227.
Scopus8 WoS7 Europe PMC52000 Musgrave, I. F., & Badoer, E. (2000). Harmane produces hypotension following microinjection into the RVLM: Possible role of I<inf>1</inf>-imidazoline receptors. British Journal of Pharmacology, 129(6), 1057-1059.
Scopus60 WoS56 Europe PMC291999 Musgrave, I. F., & Hughes, R. A. (1999). Novel targets and techniques in imidazoline receptor research. Annals of the New York Academy of Sciences, 881(1), 301-312.
Scopus12 WoS10 Europe PMC91998 Musgrave, I. F., & Hughes, R. A. (1998). Investigation of I<inf>1</inf>-imidazoline receptors using microphysiometry and molecular modelling. Journal of the Autonomic Nervous System, 72(2-3), 137-146.
Scopus5 WoS5 Europe PMC41998 Grigg, M., Musgrave, I. F., & Barrow, C. J. (1998). Isolation and partial structure determination of a clonidine-displacing substance from bovine lung and brain. Journal of the Autonomic Nervous System, 72(2-3), 86-93.
Scopus7 WoS7 Europe PMC61998 Head, G. A., Gundlach, A. L., & Musgrave, I. F. (1998). Recent advances in imidazoline receptor research: Ligands-localization and isolation-signaling-functional and clinical studies. Journal of the Autonomic Nervous System, 72(2-3), 74-79.
Scopus11 WoS8 Europe PMC81998 Chen, C., Farnworth, P., Petersenn, S., Musgrave, I., Canny, B. J., & Clarke, L. J. (1998). Growth hormone-releasing peptide-2 (GHRP-2) does not act via the human growth hormone-releasing factor receptor in GC cells. Endocrine, 9(1), 71-77.
Scopus6 WoS12 Europe PMC21998 Head, G. A., Gundlach, A. L., & Musgrave, I. F. (1998). Special issue: Imidazoline receptors - Imidazoline Receptor Workshop, 10 September 1997, Melbourne, Australia - Introduction. JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 72(2-3), 73. 1998 Musgrave, I. F., Kotsopoulos, D., & Hughes, R. A. (1998). Ion channel modulators and I<sub>1</sub>-imidazoline binding sites in bovine adrenal medulla.. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 358(1), R560. 1998 Musgrave, I. F. (1998). Structure and function of protein kinases and protein phosphatases.. IDrugs : the investigational drugs journal, 1(6), 617-619.
Europe PMC11998 Editorial (1998). Journal of the Autonomic Nervous System, 72(2-3), 73.
1997 Majewski, H., Kotsonis, P., Iannazzo, L., Murphy, T. V., & Musgrave, I. F. (1997). Protein kinase C and transmitter release. Clinical and Experimental Pharmacology and Physiology, 24(8), 619-623.
Scopus16 WoS16 Europe PMC111996 Wenzel-Seifert, K., Krautwurst, D., Musgrave, I., & Seifert, R. (1996). Thapsigargin activates univalent- and bivalent-cation entry in human neutrophils by a SK&F 96365- and Gd<sup>3+</sup>-sensitive pathway and is a partial secretagogue: Involvement of pertussis-toxin-sensitive G-proteins and protein phosphatases 1/2A and 2B in the signal-transduction pathway. Biochemical Journal, 314(2), 679-686.
Scopus28 WoS27 Europe PMC171995 Musgrave, I. F., & Seifert, R. (1995). α<inf>2A</inf>-adrenoceptors mediate activation of non-selective cation channels via G<inf>i</inf>-proteins in human erythroleukaemia (HEL) cells. No evidence for a functional role of imidazoline receptors in modulating calcium. Biochemical Pharmacology, 49(2), 187-196.
Scopus21 WoS22 Europe PMC151995 Schroeder, G. E., Kotsonis, P., Musgrave, I. F., & Majewski, H. (1995). Protein kinase C involvement in maintenance and modulation of noradrenaline release in the mouse brain cortex. British Journal of Pharmacology, 116(6), 2757-2763.
Scopus18 WoS16 Europe PMC121995 MUSGRAVE, I. F., KRAUTWURST, D., HESCHELER, J., & SCHULTZ, G. (1995). Clonidine and Cirazoline Inhibit Activation of Nicotinic Channels in PC‐12 Cells. Annals of the New York Academy of Sciences, 763(1), 272-282.
Scopus22 Europe PMC111995 Musgrave, I. F., & Seifert, R. (1995). Alpha 2A-adrenoceptors mediate activation of non-selective cation channels via Gi-proteins in human erythroleukaemia (HEL) cells. No evidence for a functional role of imidazoline receptors in modulating calcium.. Biochem Pharmacol, 49(2), 187-196.
1994 Musgrave, I. F., & Seifert, R. (1994). Human neutrophils and HL-60 cells do not possess α<inf>2</inf>-adrenoceptors. Biochemical Pharmacology, 47(2), 233-239.
Scopus11 WoS11 Europe PMC81994 Musgrave, I. F., Seifert, R., & Schultz, G. (1994). Maitotoxin activates cation channels distinct from the receptor-activated non-selective cation channels of HL-60 cells. Biochemical Journal, 301(2), 437-441.
Scopus38 WoS36 Europe PMC221994 MUSGRAVE, I. F., SEIFERT, R., & SCHULTZ, G. (1994). MATIOTOXIN STIMULATES CALCIUM INFLUX IN HL-60 CELLS THROUGH A PATHWAY DISTINCT FROM RECEPTOR-ACTIVATED NONSELECTIVE CATION CHANNELS. BRITISH JOURNAL OF PHARMACOLOGY, 112, U214. 1993 Musgrave, I. F., Genieser, H. G., Maronde, E., & Seifert, R. (1993). Preparations of Rp-cyclic adenosine 3',5'-phosphorothioate (Rp-cAMPS) can contain biologically active amounts of adenosine. FEBS Letters, 318(3), 227-230.
Scopus7 WoS6 Europe PMC41991 Musgrave, I. F., Foucart, S., & Majewski, H. (1991). Evidence that angiotensin II enhances noradrenaline release from sympathetic nerves in mouse atria by activating protein kinase C. Journal of Autonomic Pharmacology, 11(4), 211-220.
Scopus29 WoS30 Europe PMC171991 Foucart, S., Musgrave, I. F., & Majewski, H. (1991). Long term treatment with phorbol esters suggests a permissive role for protein kinase C in the enhancement of noradrenaline release. Molecular Neuropharmacology, 1(3), 95-101.
Scopus121990 Foucart, S., Musgrave, I. F., & Majewski, H. (1990). Inhibition of noradrenaline release by neuropeptide Y does not involve protein kinase C in mouse atria. Neuropeptides, 15(4), 179-185.
Scopus10 WoS12 Europe PMC81990 MAJEWSKI, H., COSTA, M., FOUCART, S., MURPHY, T. V., & MUSGRAVE, I. F. (1990). Second Messengers Are Involved in Facilitatory but Not Inhibitory Receptor Actions at Sympathetic Nerve Endings. Annals of the New York Academy of Sciences, 604(1), 266-275.
Scopus20 Europe PMC101990 MUSGRAVE, I. F., FOUCART, S., & MAJEWSKI, H. (1990). ANGIOTENSIN-II ENHANCES NORADRENALINE RELEASE FROM SYMPATHETIC-NERVES THROUGH ACTIVATION OF PROTEIN-KINASE-C. BLOOD VESSELS, 27(1), 50. 1990 Musgrave, I. F., Foucart, S., & Majewski, H. (1990). Angiotensin II enhances stimulation-induced noradrenaline release from sympathetic nerves through protein kinase C. European Journal of Pharmacology, 183(4), 1486-1487.
1989 Majewski, H., & Musgrave, I. F. (1989). G proteins and α-adrenoceptor classification. Trends in Pharmacological Sciences, 10(1), 14.
Scopus1 WoS31989 Rajanayagam, M. A. S., Musgrave, I. F., Rand, M. J., & Majewski, H. (1989). Facilitation of noradrenaline release by isoprenaline is not mediated by angiotensin II in mouse atria and rat tail artery. Archives Internationales de Pharmacodynamie et de Therapie, 299, 185-199.
Scopus14 WoS14 Europe PMC101989 Musgrave, I. F., & Majewski, H. (1989). Effect of phorbol ester and pertussis toxin on the enhancement of noradrenaline release by angiotensin II in mouse atria. British Journal of Pharmacology, 96(3), 609-616.
Scopus22 WoS23 Europe PMC201989 Musgrave, I. F., & Majewski, H. (1989). Effect of phorbol esters and polymyxin B on modulation of noradrenaline release in mouse atria. Naunyn-Schmiedeberg's Archives of Pharmacology, 339(1), 48-53.
Scopus30 WoS30 Europe PMC151989 Musgrave, I. F., Foucart, S., & Majewski, H. (1989). Do phorbol myristate and phorbol dibutyrate enhance noradrenaline release by the same mechanisms?. British journal of pharmacology, 98 Suppl, 776P.
Scopus3 Europe PMC21987 Musgrave, I., Marley, P., & Majewski, H. (1987). Pertussis toxin does not attenuate α<inf>2</inf>-adrenoceptor mediated inhibition of noradrenaline release in mouse atria. Naunyn-Schmiedeberg's Archives of Pharmacology, 336(3), 280-286.
Scopus45 WoS54 Europe PMC331987 Johnston, H., Majewski, H., & Musgrave, I. F. (1987). Involvement of cyclic nucleotides in prejunctional modulation of noradrenaline release in mouse atria. British Journal of Pharmacology, 91(4), 773-781.
Scopus53 WoS54 Europe PMC461985 Musgrave, I. F., Bachmann, A. W., Jackson, R. V., & Gordon, R. D. (1985). INCREASED PLASMA NORADRENALINE DURING LOW DOSE ADRENALINE INFUSION IN RESTING MAN AND DURING SYMPATHETIC STIMULATION. Clinical and Experimental Pharmacology and Physiology, 12(3), 285-289.
Scopus27 WoS31 Europe PMC191984 Musgrave, I. F., Bachmann, A. W., Saar, N., & Gordon, R. D. (1984). A comparison of cardiovascular and catecholamine responses to three stimuli in mild hypertension. Metabolism, 33(8), 718-723.
Scopus18 WoS17 Europe PMC101984 Musgrave, I. F., Bachmann, A. W., & Gordon, R. D. (1984). Increased plasma noradrenaline during adrenaline infusion in man.. Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 2(3), S135-S137.
Europe PMC21984 Musgrave, I., Bachmann, A., & Gordon, R. (1984). Increased plasma noradrenaline during adrenaline infusion in man. Journal of Hypertension, 2(SUPPL. 3), 135-137.
Scopus26 -
Book Chapters
Year Citation 2013 Smid, S., & Musgrave, I. (2013). Dietary polyphenols as inhibitors of Β-amyloid-evoked neurotoxicity: implications for the treatment of Alzheimer's disease. In J. Sun, K. Prasad, A. Ismail, B. Yang, X. You, & L. Li (Eds.), Polyphenols: Chemistry, Dietary Sources and Health Benefits (1 ed., pp. 521-538). United States: Nova Science Publishers. 1999 Musgrave, I., & Barrow, C. (1999). Imidazoline Receptors and Their Endogenous Ligands. In The Biology - Chemistry Interface. CRC Press.
1990 Myles, G. (1990). Introduction. In G. Myles (Ed.), Measurement and Modelling in Economics (Vol. 72, pp. 461 pages). Elsevier.
- E., I., Rittschof, D., H., G., & Musgrave, I. (n.d.). Evolutionary Proteomics: Empowering Tandem Mass Spectrometry and Bioinformatics Tools for the Study of Evolution. In Tandem Mass Spectrometry - Applications and Principles. InTech.
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Conference Papers
Year Citation 2023 Britza, S., Farrington, R., Byard, R., & Musgrave, I. (2023). Psoralen-induced toxicity in metabolically variable cell models altered in presence of purported cytochrome P450 modulators astragaloside IV and atractylenolide I. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 180 (pp. 1354-1356). Glasgow, SCOTLAND: WILEY. 2023 Britza, S., Farrington, R., Byard, R., & Musgrave, I. (2023). In vitro demonstration of herbal exacerbation of paracetamol-induced hepatotoxicity. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 180 (pp. 1347-1348). Glasgow, SCOTLAND: WILEY. 2015 Smid, S., Das, S., Musgrave, I., & Pukala, T. (2015). Bioactive polyphenol interactions with β amyloid: a comparison of binding, fibril inhibition and neuroprotection. In JOURNAL OF NEUROCHEMISTRY Vol. 134 (pp. 363-364). Cairns, AUSTRALIA: WILEY-BLACKWELL. 1996 Musgrave, I. F., Krautwurst, D., & Schultz, G. (1996). Imidazoline binding sites and signal transduction pathways. In Clinical and Experimental Pharmacology and Physiology Vol. 23 (pp. 990-994). ADELAIDE, AUSTRALIA: BLACKWELL SCIENCE.
Scopus16 WoS17 Europe PMC121995 Majeuiski, H. K., & Musgrave, I. F. (1995). Second messenger pathways in the modulation of neurotransmitter release. In Australian and New Zealand Journal of Medicine Vol. 25 (pp. 817-821). CENTENARY INST MED & CELL BIOL, SYDNEY, AUSTRALIA: ADIS PRESS AUSTRALASIA P/L.
Scopus10 WoS9 Europe PMC51990 MAJEWSKI, H., COSTA, M., FOUCART, S., MURPHY, T. V., & MUSGRAVE, I. F. (1990). 2ND MESSENGERS ARE INVOLVED IN FACILITATORY BUT NOT INHIBITORY RECEPTOR ACTIONS AT SYMPATHETIC-NERVE ENDINGS. In S. KALSNER, & T. C. WESTFALL (Eds.), PRESYNAPTIC RECEPTORS AND THE QUESTION OF AUTOREGULATION OF NEUROTRANSMITTER RELEASE Vol. 604 (pp. 266-275). PHILADELPHIA, PA: NEW YORK ACAD SCIENCES.
WoS22 -
Conference Items
Year Citation 2014 O'Neill, K., & Musgrave, I. (2014). The effect of saxitoxin on the differentiation of D3 embryonic stem cells into a neural lineage. Poster session presented at the meeting of TOXICOLOGY LETTERS. Edinburgh, SCOTLAND: ELSEVIER IRELAND LTD.
2011 Smid, S., Salem, A., & Musgrave, I. (2011). Blended learning approaches to practical teaching in pharmacology: the best of both worlds?. Poster session presented at the meeting of Transformation. Adelaide, Australia. 2010 Salem, A., Smid, S., Musgrave, I., & Carrington, A. (2010). Development and integration of web-based pharmacology e-resources designed to provide immediate feedback and interactive help. Poster session presented at the meeting of The Education Research Group of Adelaid. Adelaide, Australia: The University of Adelaide.
| Date | Project/ No. | Investigators | Funding Body |
|---|---|---|---|
|
2020 |
“Inhibition of dental biofilms using natural Quorum Sensing Inhibitors investigated with the xCELLigence ® Real Time Cell Analyser.” 2555-2020 | Stuckings Z; Musgrave I; Kidd S; Zilm P | Australian Dental Research Foundation Inc. 2555-2020 |
|
2018 |
“Anticoagulant rodenticide excretion in rats following median lethal dose (LD50) administration” | Hamilton, Jolley, Howard, Musgrave | Australian Pork Limited Project 2018/0011 |
| 2018 | ‘More than providing a microphone: Establishing a research cluster for public engagement with STEM research and policy' | Ankeny R et al., | Interdisciplinary Research Fund. (University of Adelaide Internal Grant) |
|
2017 |
Australian Pork Limited "rodenticide feeding study in rats" | Hamilton, Jolley, Howard, Musgrave | Australian Pork Limited APL Project 2016/2230 |
|
2016 |
In vitro toxicology assessment of herbal medicines. | Maker et al. | Murdoch University Small Grant |
| 2014 | Development of 'omics-based approaches to investigate labelling accuracy and legality of herbal medicine in Australia | Bunce M et al. | NHMRC APP1061329 |
| 2013 | Structure function relationships of anti-amyloid drugs: verification in an in-vivo model. | Musgrave IF, Smid SD, Pukala T, O’Keefe L | Interdisciplinary Research Fund (University of Adelaide Internal Grant) |
| 2010 |
Development and integration of software for practicum delivery and assessment in third year pharmacology courses |
Smid SD, Salem A, Musgrave IF | University of Adelaide Internal Grant |
| 2009 |
Enzymatic synthesis, microencapsulation and biological evaluation of a new class of omega-3 derivedfunctional food ingredients. |
Barrow et al. | ARC Linkage Grant LP100100069 |
| 2009 | New drug treatments for Alzhemier’s disease | Smid SD, Musgrave IF | Sunshine Foundation Grant |
| 2009 | Development and evaluation of on-line assessment materials for a second year compulsory course within the Bachelor of Health Sciences program | Salem A, Smid SD, Musgrave IF, Carrington A | University of Adelaide Internal Grants |
| 2007 | Ensuring Quality Graduates of Pharmacology | ALTC (formerly Carrick) Education Grant (member of ASCEPT Education consortium) | |
| 2006 |
|
Ingman W, Musgrave IF, and Robertson SA | Faculty Small Grant |
| 2006 | Ingman W, Musgrave IF, and Robertson SA | Faculty Small Grant | |
| 2004 | Burcham P, Musgrave IF | SA Brain Foundation Grant | |
| 2004 | Musgrave IF, Piletz J and Head G | University of Adelaide, Faculty of Health Sciences Small Grants | |
| 2003 |
|
Musgrave IF | University of Adelaide, Faculty of Health Sciences Travelling Fellowship Grant for Professor John Piletz |
| 2003 | Musgrave IF | SA Brain Foundation grant | |
| 2002 | Musgrave IF et al. | Rebecca Cooper Foundation grant | |
| 2001 | Musgrave IF | Adelaide University, B3 New Appointment grant | |
| 1999 | Identification of a new endogenous ligand for imidazoline receptors. | Barrow C, Musgrave IF | ARC small grant |
| 1999 | Electrophysiology –Single cell fluorescence setup | Majewski H, Chen C, Musgrave IF, Li C-G, Badoer E | Wellcome Trust Equipment Grant |
| 1997 |
Imidazoline receptors and modulation of ion channels |
Musgrave IF | NH&MRC project grant 981123 |
| 1995 | Imidazoline receptors modulate nicotinic ion channels. | Musgrave IF | Ramaciotti Foundation Grant |
| 1992 | Musgrave IF | NH&MRC CJ Martin Fellowship | |
| 1990 | Musgrave IF | Alexander Von Humboldt Fellowship | |
| 1989 | Role of PKC on sympathetic transmitter release | Majewski H & Musgrave IF | NH&MRC Project grant |
Undergraduate
| Date | Course Details |
|---|---|
| 2013-present | Course coordinator PHARM 3010 Drug Action and Discovery |
| 2013-2018 | Course co-ordinator, Dental& Health Science III and IV (Pharmacology Stream) |
| 2010-2011 | Course coordinator Drug Discovery and Development (PHARM 4200 and lecturer) |
| 2008-2016 | Lecturing for B. Pharm Eng. PHARM 2002 and 2003 rebadged as PHARM 2100 and PHARM 2200, Course coordinator, lecturer and workshop leader PHARM 2200, Drugs Chemicals and the Environment |
| 2007-2013 |
Course co-ordinator, Dental& Health Science IV (Pharmacology Stream) |
| 2007-present | Lecturer in nursing courses, tutor in Dental& Health Science IV (Pharmacology Stream). |
| 2006-2013 | Course coordinator, 2nd year courses (PHARM 2002, 2003, Drugs Chemicals and Health and Drugs Chemicals and the Environment respectively). Lecturer, tutor and demonstrator in 2nd, 3rd year BSc.BHealth Sc. Courses (PHARM 2002, 2003, 3010, 3011). Workshop leader in 2nd year courses, B.Health Sc |
| 2004-2005 |
Course co-ordinator, 3rd year second semester courses, Pharmacology BIII, B.Sc. 2004. Concepts in Pharmacology BIII and Research Methods in Pharmacology BIII B.Health Sc. 2004; Lecturer, tutor and demonstrator in 3rd year BSc.BHealth Sc. courses. Workshop participant in Fundamentals in Drug Development 3rd year BHealth Sc. Lecturer, tutor, workshop leader in 2nd year course, B.Health Sc. |
| 2002-2003 | Course co-ordinator, 3rd year second semester course, Advanced topics in Pharmacology, B.Sc. B.Health Sc. 2003. Lecturing, tutoring and practical class co-ordination, third year basic and advanced pharmacology course B.Sc. B.Health Sc. Lecturer, tutor, workshop leader in 2nd year course, B.Health Sc |
| 2001 |
Lecturing, tutoring and practical class co-ordination, third year basic and advanced pharmacology course. Department of Clinical and Experimental Pharmacology, Adelaide University: B.Sc. B.Health Sc. |
| 1999-2000 |
Lecturing, and practical class demonstrating, Department of Medical Laboratory Science, RMIT University: B App Sc. |
| 1991-1998 | Lecturing, and practical class demonstrating, Department of Pharmacology, Monash University: BSc (Hons), BSc |
| 1987-1990 | Lecturing, tutoring and practical class demonstrating Department of Pharmacology, University of Melbourne BSc (Hons), BSc, Dentistry, Medicine |
Teaching Development
| Date | Course Details |
|---|---|
| 2016 | Invited speaker, 3D visualisations of drug-receptor interactions |
| 2011 | Invited Speaker, ASCEPT Education Workshop (Perth): speaking on Physical Theatre as a metod of student engagement |
| 2010 | Presentation of ALTC (formerly Carrick) grant “Ensuring Quality Graduates of Pharmacology” material at WorldPharma |
| 2009 | Finalised report on the ALTC (formerly Carrick) grant “Ensuring Quality Graduates of Pharmacology Member, ASCEPT Mentoring scheme |
| 2008 |
Invited Speaker, ASCEPT Education Workshop (Sydney): speaking on Votapedia as a novel assessment tool |
| 2007-present | Carrick Education Grant team member |
| 2007-present | Member ASCEPT Education Special Interest Group |
| 2007 | Participant, ASCEPT Teaching Workshop |
| 2006-2007 | Colleague Development Program participant |
| 2006 | HARC mentoring round table |
| 2003 | Teaching at University Course |
| 2003 | Member of ASCEPT core curriculum development group |
| 2001-present | Various service courses for using MyUni |
Other Teaching Service
2006 -2009 Member Teacher Twinning Group (support to high School Science Teachers)
School Service
| Date | Service |
|---|---|
| 2009-2012 | School Honours Coordinator |
| 2007-2008 | Convenor School Research Committee (School RQF coordinator, ERA response co-ordinator, submission of responses to State Gov’t inquiry into the future of research in South Australia, coordinator School Grant Review process) |
| 2007-present | Member OH&S Committee |
| 2006-2012 | Member School Research Committee |
| 2006-2013 | Open Day co-ordinator for Discipline, then School |
Departmental Service
| Date | Details |
|---|---|
| 2009-2012 | Discipline honours Co-ordinator, Teaching and Learning committee |
| 2007-2008 | B. Pharm Eng course development. Teaching and Learning committee, Marketting Committee |
| 2006 | Seminar co-ordinator, Teaching and Learning committee, B. Pharm Eng development. Marketting Committee |
| 2005 | Seminar co-ordinator, Teaching and Learning committee, third year development group. Open day co-ordinator. |
| 2004 | Seminar co-ordinator, Teaching and Learning committee, third year development group. Open day co-ordinator |
| 2003 | Seminar co-ordinator, Equipment committee, Teaching and Learning committee, third year development group, Open day co-ordinator, ASMR research day co-ordinator. |
| 2002 |
ASMR research day co-ordinator. |
| 2001 | Departmental Research Committee, Faculty of Science board, Second year development group |
| 2000 | RMIT Departmental seminar organiser |
| 1999-2000 | Drug Research and Development Group management committee |
| 1999-2000 | Medical Laboratory Science Research Committee |
| 1994-1998 | Prince Henry's Institute of Medical Research, Institute Scientific Group (Chairman: 1995-1996) |
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2023 Co-Supervisor Exogenous Ketogenic Therapy to Inhibit the Symptoms Caused by BACE1 in Drosophila and Protect Mitochondria Doctor of Philosophy Doctorate Full Time Mr Hao Huang 2022 Co-Supervisor Neuroprotective characterisations of cannabis phytochemicals Doctor of Philosophy Doctorate Full Time Mr John Laws III 2022 Co-Supervisor Nanoparticle based strategies for the treatment of Parkinson's Disease: opportunities and challenges Doctor of Philosophy Doctorate Full Time Miss Laura May Carr 2021 Co-Supervisor From Magic to Medicine: The dynamics of faith and science in drug development in antiquity. Master of Philosophy Master Part Time Mr Greg Macpherson -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2022 - 2023 Principal Supervisor The significance of OATP and CYP450 in statin-flavonoid interactions Master of Philosophy (Medical Science) Master Full Time Mr Joshua Paul Zechner 2018 - 2023 Principal Supervisor The Role of Cytokines in Neuronal Injury and Neurodegenerative Diseases Doctor of Philosophy Doctorate Full Time Miss Anuradha Subashini Tennakoon 2017 - 2022 Principal Supervisor Implications for toxicity in herbal polypharmacy: the role of herb-herb interactions and cytotoxic development in at-risk organ models Doctor of Philosophy Doctorate Full Time Dr Susan Marie Britza 2017 - 2022 Co-Supervisor Exploring the Bioactivity and Therapeutic Potential of Structurally Diverse Phytochemicals in Neurodegenerative and Gastrointestinal Disease Doctor of Philosophy Doctorate Full Time Mr Dylan Thomas Marsh 2016 - 2019 Principal Supervisor Herbal Medicine Toxicity, the Role of Adulterants, Contaminants and Pharmokinetic Interactions Doctor of Philosophy Doctorate Full Time Dr Rachael Louise Farrington 2015 - 2018 Co-Supervisor Small molecular inhibitors of Amyloid beta and alpha Synuclein amyloidogenic aggregation, toxicity and in silico design of amyloid-binding ligands Doctor of Philosophy Doctorate Full Time Mrs Sukanya Das 2013 - 2018 Co-Supervisor A Comparative Study of Physiological and Modulators of Aquaporin ion Channels in Diverse Phyla Doctor of Philosophy Doctorate Full Time Mohamad Kourghi 2013 - 2020 Principal Supervisor Herbal Medicine use in the Australian Population: Adulteration, Contamination and Adverse Drug Reactions Doctor of Philosophy Doctorate Part Time Mrs Claire Louise Hoban 2012 - 2017 Principal Supervisor The Effect of the Cyanobacterial Toxin Saxitoxin on Neurodevelopment Doctor of Philosophy Doctorate Full Time Katie O'Neill 2011 - 2015 Co-Supervisor The Functional Studies of Amyloid Fibrils and their Toxicity Doctor of Philosophy Doctorate Full Time Abigail Kegomoditswe Elias 2010 - 2011 Co-Supervisor Characterization of the zebrafish Orthologue of Klotho Master of Science Master Full Time Mr Yuya Sugano 2010 - 2014 Co-Supervisor The Effect of Cannabinoids on Cytokine Evoked Human Colonic Mucosal Damage and Caco-2 Epithelial Permeability Doctor of Philosophy Doctorate Full Time Mr Benjamin Harvey 2005 - 2010 Co-Supervisor Genotoxicity Investigation of Organic N-Chloramines Doctor of Philosophy Doctorate Full Time Mr Somprasong Laingam 2004 - 2008 Principal Supervisor Imidazoline Receptor Antisera - Selected Protein: A Unique Modulator of Neuronal Differentiation Doctor of Philosophy Doctorate Part Time Mr Francis Dehle
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Board Memberships
Date Role Board name Institution name Country 2013 - ongoing Director Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists management board Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Australia -
Committee Memberships
Date Role Committee Institution Country 2019 - ongoing Member ASCEPT Scientific Organising Comittee Australasian Society for Clinical and Experimental Pharmacology and Toxicology Australia 2019 - 2022 Member International Union of Toxicology Nominating Committee International Union of Toxicology United States 2016 - ongoing Member Occupational Helath and Safety Comittee University of Adelaide Australia 2012 - ongoing Member Australian Science Communicators South Australian Branch - - 2010 - ongoing Chair Toxicology Special Interest Group Australian Society of Clinical and Experimental Pharmacologists and Toxicologist Australia 2009 - 2010 Member Aging Research Round Table State Office for the Ageing, Department for Families and Communities Australia 2009 - 2010 Member Toxicology Special Interest Group Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Australia 2007 - 2010 Member Adelaide Healthy Ageing Research Cluster Healthy Ageing Research Cluster Australia 2004 - 2006 Member Interim Management Group Adelaide Healthy Ageing Research Cluster (HARC) Australia -
Memberships
Date Role Membership Country 2019 - ongoing Member High Blood Pressure Research Council of Australia Australia 2019 - ongoing Member Forensic and Clinical Toxicology Association Australia 1995 - ongoing Member Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Australia 1995 - ongoing Member Australasian Neuroscience Society Australia -
Consulting/Advisories
Date Institution Department Organisation Type Country 2019 - 2019 SA health Systems Performance and Service Delivery Health services and related Australia 2018 - 2019 Commonwealth of Australia Senate RURAL AND REGIONAL AFFAIRS AND TRANSPORT REFERENCES COMMITTEE Legislative and political Australia 2018 - 2018 Consumer and Business Services (CBS), South Australia Product safety section Health services and related Australia -
Offices Held
Date Office Name Institution Country 2019 - 2021 Nominating comittee International Union of Toxicologists United States 2010 - ongoing Chair, Toxicology Special Interest group Australasian Society of Clinical and Experimental Pharmacologists and Toxicologistss Australia
Connect With Me
External Profiles
