David Haynes

School of Biomedicine

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Professor David R Haynes is Deputy Head of the School of Medicine, University of Adelaide. He has published well over 100 publications in respected peer reviewed journals. Over the past two decades he has developed a respected international reputation in the fields of bone pathologies, biomaterials and inflammation.

Over the past decade he has been President and Secretary of the Australian and New Zealand Society of Orthopaedic Research (www.ANZORS.org.au). In these roles he has help organise more than 5 national and 3 international meetings.

Professor Haynes has been chief investigator on more than 17 successful major national and international grants (NH&MRC, European Union Framework 7 and ARC) grants since the early 1990’s as well as several commercially funded studies on pharmacological regulation of inflammatory cytokines, pathogenic bone loss and implant loosening. He also makes a significant contribution to the training of medical students (MBBS), Health Science students and Nursing students in the Faculty of Health and Medical Sciences.

Career
Publications
Grants and Funding
Teaching
Supervision
Professional Activities
Contact

Appointments

Date	Position	Institution name
2015 - 2016	Professor & Deputy Head	University of Adelaide
2013 - 2015	Head of the School of Medical Sciences	University of Adelaide, Adelaide
2010 - 2015	Associate Professor	University of Adelaide
2009 - 2013	Head of Anatomy and Pathology	University of Adelaide, Adelaide
2006 - 2010	Senior Lecturer	University of Adelaide
2000 - 2006	Lecturer	University of Adelaide
1994 - 2000	Scientific Officer	University of Adelaide
1982 - 1994	Technical Officer	University of Adelaide
1978 - 1982	Research assistant/technical assistant	University of Adelaide

Awards and Achievements

Date	Type	Title	Institution Name	Country	Amount
2012	Award	The Presidents Prize for Collaborative Research , Australian Arthritis Association.	-	Australia	-
2012	Award	Prof Malcolm Smith The Presidents Prize for Collaborative Research 2012	Australian Arthritis Association	-	-
2006	Award	Awarded Subspeciallity Showcase ASM Hobart Australian Orthopaedic Association 2008.	-	Australia	-

Education

Date Institution name Country Title
University of Adelaide Australia BSc
University of Adelaide Australia BSc Hons
University of Adelaide Australia PhD (Med)
Research Interests

Arthritis & Rheumatology Biomaterials Orthopaedics Pathology Periodontics Musculoskeletal Health Oral Health Immunology and Infection Innovative Therapeutics

Institution name	Country	Title
University of Adelaide	Australia	BSc
University of Adelaide	Australia	BSc Hons
University of Adelaide	Australia	PhD (Med)

Journals

Year	Citation
2023	Ng, J. Q., Jafarov, T. H., Little, C. B., Wang, T., Ali, A., Ma, Y., . . . Mukherjee, S. (2023). Loss of Grem1-articular cartilage progenitor cells causes osteoarthritis.. bioRxiv. DOI
2023	Ng, J. Q., Jafarov, T. H., Little, C. B., Wang, T., Ali, A. M., Ma, Y., . . . Mukherjee, S. (2023). Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis. Nature Communications, 14(1), 6909-1-6909-14. DOI Scopus1 Europe PMC1
2020	Algate, K., Haynes, D., Fitzsimmons, T., Romeo, O., Wagner, F., Holson, E., . . . Cantley, M. (2020). Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro. Journal of Cellular Biochemistry, 121(1), 244-258. DOI Scopus17 WoS15 Europe PMC8
2019	Bartold, M., Gronthos, S., Haynes, D., & Ivanovski, S. (2019). Mesenchymal stem cells and biologic factors leading to bone formation. Journal of Clinical Periodontology, 46(S21), 12-32. DOI Scopus40 WoS24 Europe PMC25
2019	Ormsby, R. T., Solomon, L. B., Yang, D., Crotti, T. N., Haynes, D. R., Findlay, D. M., & Atkins, G. J. (2019). Osteocytes respond to particles of clinically-relevant conventional and cross-linked polyethylene and metal alloys by up-regulation of resorptive and inflammatory pathways. Acta Biomaterialia, 87, 296-306. DOI Scopus40 WoS32 Europe PMC21
2017	Cantley, M. D., Zannettino, A. C. W., Bartold, P. M., Fairlie, D. P., & Haynes, D. R. (2017). Histone deacetylases (HDAC) in physiological and pathological bone remodelling. Bone, 95, 162-174. DOI Scopus42 WoS33 Europe PMC25
2017	Cantley, M., Rainsford, K., & Haynes, D. (2017). Yeast RNA extract suppresses human osteoclast resorption in vitro. Inflammopharmacology, 25(5), 571-576. DOI
2016	Saad, S., Dharmapatni, A., Crotti, T., Cantley, M., Algate, K., Findlay, D., . . . Haynes, D. (2016). Semaphorin-3a, neuropilin-1 and plexin-A1 in prosthetic-particle induced bone loss. Acta Biomaterialia, 30, 311-318. DOI Scopus18 WoS14 Europe PMC12
2016	Algate, K., Haynes, D., Bartold, P., Crotti, T., & Cantley, M. (2016). The effects of tumour necrosis factor-α on bone cells involved in periodontal alveolar bone loss; osteoclasts, osteoblasts and osteocytes. Journal of Periodontal Research, 51(5), 549-566. DOI Scopus82 WoS65 Europe PMC44
2016	Ormsby, R., Cantley, M., Kogawa, M., Solomon, L., Haynes, D., Findlay, D., & Atkins, G. (2016). Evidence that osteocyte perilacunar remodelling contributes to polyethylene wear particle induced osteolysis. Acta Biomaterialia, 33, 242-251. DOI Scopus58 WoS46 Europe PMC29
2016	Hynes, K., Bright, R., Proudman, S., Haynes, D., Gronthos, S., & Bartold, M. (2016). Immunomodulatory properties of mesenchymal stem cell in experimental arthritis in rat and mouse models: a systematic review. Seminars in Arthritis and Rheumatism, 46(1), 1-19. DOI Scopus21 WoS19 Europe PMC16
2016	Cantley, M., Dharmapatni, A., Algate, K., Crotti, T., Bartold, P., & Haynes, D. (2016). Class I and II histone deacetylase expression in human chronic periodontitis gingival tissue. Journal of Periodontal Research, 51(2), 143-151. DOI Scopus22 WoS17 Europe PMC13
2015	Crotti, T., Dharmapatni, A., Alias, E., & Haynes, D. (2015). Osteoimmunology: major and costimulatory pathway expression associated with chronic inflammatory induced bone loss. Journal of Immunology Research, 2015, 281287-1-281287-13. DOI Scopus93 WoS82 Europe PMC69
2015	Dharmapatni, A., Cantley, M., Marino, V., Perilli, E., Crotti, T., Smith, M., & Haynes, D. (2015). The X-Linked Inhibitor of Apoptosis Protein inhibitor embelin suppresses inflammation and bone erosion in collagen antibody induced arthritis mice. Mediators of Inflammation, 2015, 564042-1-564042-10. DOI Scopus18 WoS15 Europe PMC12
2015	Perilli, E., Cantley, M., Marino, V., Crotti, T., Smith, M., Haynes, D., & Dharmapatni, A. (2015). Quantifying not only bone loss, but also soft tissue swelling, in a murine inflammatory arthritis model using micro-computed tomography. Scandinavian Journal of Immunology, 81(2), 142-150. DOI Scopus18 WoS16 Europe PMC12
2015	Zawawi, M., Perilli, E., Stansborough, R., Marino, V., Cantley, M., Xu, J., . . . Crotti, T. (2015). Caffeic accid phenethyl ester abrogates bone resorption in a murine calvarial model of polyethylene particle-induced osteolysis. Calcified Tissue International, 96(6), 565-574. DOI Scopus20 WoS14 Europe PMC12
2015	Cantley, M., Fairlie, D., Bartold, P., Marino, V., Gupta, P., & Haynes, D. (2015). Inhibiting histone deacetylase 1 suppresses both inflammation and bone loss in arthritis. Rheumatology, 54(9), 1713-1723. DOI Scopus58 WoS53 Europe PMC33
2015	Zawawi, M., Marino, V., Perilli, E., Cantley, M., Xu, J., Purdue, P., . . . Crotti, T. (2015). Parthenolide reduces empty lacunae and osteoclastic bone surface resorption induced by polyethylene particles in a murine calvarial model of peri-implant osteolysis. Journal of Biomedical Materials Research Part A, 103(11), 3572-3579. DOI Scopus17 WoS13 Europe PMC9
2014	Gully, N., Bright, R., Marino, V., Marchant, C., Cantley, M., Haynes, D., . . . Bartold, M. (2014). Porphyromonas gingivalis peptidylarginine deiminase, a key contributor in the pathogenesis of experimental periodontal disease and experimental arthritis. PLoS One, 9(6), e100838-1-e100838-12. DOI Scopus85 WoS78 Europe PMC67
2013	Rainsford, K. D., & Haynes, D. R. (2013). Erratum to: Professor Barrie Vernon-Roberts, AO, MD, BSc, PhD, FRCPath, FRCPA, FAOrthA (Hon), FRS.SA (vol 21, pg 269, 2013). INFLAMMOPHARMACOLOGY, 21(5), 387. DOI
2013	Harvey, G., Fitzsimmons, T., Dharmapatni, A., Marchant, C., Haynes, D., & Bartold, P. (2013). Expression of peptidylarginine deiminase-2 and -4, citrullinated proteins and anti-citrullinated protein antibodies in human gingiva. Journal of Periodontal Research, 48(2), 252-261. DOI Scopus126 WoS110 Europe PMC82
2013	Gannon, S., Cantley, M., Haynes, D., Hirsch, R., & Bartold, P. (2013). Azithromycin suppresses human osteoclast formation and activity in vitro. Journal of Cellular Physiology, 228(5), 1098-1107. DOI Scopus20 WoS16 Europe PMC15
2013	Cantley, M., Rainsford, K., & Haynes, D. (2013). Comparison of the ability of chondroitin sulfate derived from bovine, fish and pigs to suppress human osteoclast activity in vitro. Inflammopharmacology, 21(6), 407-412. DOI Scopus10 WoS7 Europe PMC6
2013	Howie, D., Neale, S., Haynes, D., Holubowycz, O., McGee, M., Solomon, L., . . . Findlay, D. (2013). Periprosthetic osteolysis after total hip replacement: molecular pathology and clinical management. Inflammopharmacology, 21(6), 389-396. DOI Scopus38 WoS30 Europe PMC22
2013	Cantley, M., Rainsford, K., & Haynes, D. (2013). Effects of Osteochondrin S and select connective tissue ribonucleinate components on human osteoclasts in vitro. Journal of Pharmacy and Pharmacology, 65(8), 1214-1222. DOI Scopus3 WoS3 Europe PMC1
2013	Bartold, P., Du Bois, A., Gannon, S., Haynes, D., & Hirsch, R. (2013). Antibacterial and immunomodulatory properties of azithromycin treatment implications for periodontitis. Inflammopharmacology, 21(4), 321-338. DOI Scopus31 WoS28 Europe PMC23
2013	Rainsford, K., & Haynes, D. (2013). Professor Barrie Vernon-Roberts, AO, MD, BSc, PhD, FRCPath, FRCPA, FAOrthA (Hon), FRS.SA. Inflammopharmacology, 21(4), 269-277. DOI WoS1
2013	Cantley, M., & Haynes, D. (2013). Epigenetic regulation of inflammation: progressing from broad acting histone deacetylase (HDAC) inhibitors to targeting specific HDACs. Inflammopharmacology, 21(4), 301-307. DOI Scopus62 WoS57 Europe PMC38
2012	Zawawi, M., Dharmapatni, A., Cantley, M., McHugh, K., Haynes, D., & Crotti, T. (2012). Regulation of ITAM adaptor molecules and their receptors by inhibition of calcineurin-NFAT signalling during late stage osteoclast differentiation. Biochemical and Biophysical Research Communications, 427(2), 404-409. DOI Scopus22 WoS20 Europe PMC17
2012	Alias, E., Dharmapatni, A., Holding, C., Atkins, G., Findlay, D., Howie, D., . . . Haynes, D. (2012). Polyethylene particles stimulate expression of ITAM-related molecules in peri-implant tissues and when stimulating osteoclastogenesis in vitro. Acta Biomaterialia, 8(8), 3104-3112. DOI Scopus20 WoS19 Europe PMC16
2012	Cantley, M., Bartold, P., Fairlie, D., Rainsford, K., & Haynes, D. (2012). Histone deacetylase inhibitors as suppressors of bone destruction in inflammatory diseases. Journal of Pharmacy and Pharmacology, 64(6), 763-774. DOI Scopus25 WoS19 Europe PMC12
2012	Gross, K., Muller, D., Lucas, H., & Haynes, D. (2012). Osteoclast resorption of thermal spray hydoxyapatite coatings is influenced by surface topography. Acta Biomaterialia, 8(5), 1948-1956. DOI Scopus30 WoS24 Europe PMC10
2012	Marchant, C., Smith, M., Proudman, S., Haynes, D., & Bartold, P. (2012). Effect of Porphyromonas gingivalis on citrullination of proteins by macrophages in vitro. Journal of Periodontology, Online(9), 1-15. DOI Scopus13 WoS14 Europe PMC8
2012	Upton, A., Holding, C., Dharmapatni, A., & Haynes, D. (2012). The expression of RANKL and OPG in the various grades of osteoarthritic cartilage. Rheumatology International, 32(2), 535-540. DOI Scopus37 WoS35 Europe PMC23
2012	Crotti, T., Dharmapatni, A., Alias, E., Zannettino, A., Smith, M., & Haynes, D. (2012). The immunoreceptor tyrosine-based activation motif (ITAM)-related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints. Arthritis Research & Therapy, 14(6), 1-13. DOI Scopus44 WoS40 Europe PMC33
2011	Cantley, M., Bartold, P., Marino, V., Fairlie, D., Le, G., Lucke, A., & Haynes, D. (2011). Histone deacetylase inhibitors and periodontal bone loss. Journal of Periodontal Research, 46(6), 697-703. DOI Scopus58 WoS49 Europe PMC39
2011	Cantley, M., Fairlie, D., Bartold, P., Rainsford, K., Le, G., Lucke, A., . . . Haynes, D. (2011). Inhibitors of histone deacetylases in class I and class II suppress human osteoclasts in vitro. Journal of Cellular Physiology, 226(12), 3233-3241. DOI Scopus63 WoS57 Europe PMC37
2011	Dharmapatni, A., Smith, M., Crotti, T., Holding, C., Vincent, C., Weedon, H., . . . Haynes, D. (2011). TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis. Arthritis Research & Therapy, 13(2), R51-1-R51-10. DOI Scopus34 WoS31 Europe PMC25
2011	Cantley, M., Haynes, D., Marino, V., & Bartold, P. (2011). Pre-existing periodontitis exacerbates experimental arthritis in a mouse model. Journal of Clinical Periodontology, 38(6), 532-541. DOI Scopus99 WoS90 Europe PMC78
2011	Atkins, G., Haynes, D., Howie, D., & Findlay, D. (2011). Role of polyethylene particles in peri-prosthetic osteolysis: A review. World Journal of Orthopedics, 2(10), 93-101. DOI Scopus45 WoS32 Europe PMC23
2011	Haynes, D. R. (2011). Erratum: Bone lysis and inflammation (Inflammation Research (2004) 53 (596-600)DOI 10.1007/s00011-004-1303-z). Inflammation Research, 60(10), 997. DOI
2010	Bartold, P., Cantley, M., & Haynes, D. (2010). Mechanisms and control of pathologic bone loss in periodontitis. Periodontology 2000, 53(1), 55-69. DOI Scopus179 WoS161 Europe PMC118
2010	Kataria, N., Bartold, P., Dharmapatni, A., Atkins, G., Holding, C., & Haynes, D. (2010). Expression of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor, fibroblast growth factor-inducible 14 protein (Fn14), in healthy tissues and in tissues affected by periodontitis. Journal of Periodontal Research, 45(4), 564-573. DOI Scopus18 WoS18 Europe PMC10
2010	Bartold, P., Marino, V., Cantley, M., & Haynes, D. (2010). Effect of Porphyromonas gingivalis-induced inflammation on the development of rheumatoid arthritis. Journal of Clinical Periodontology, 37(5), 405-411. DOI Scopus78 WoS67 Europe PMC61
2010	Lucas, H., Bartold, P., Dharmapatni, A., Holding, C., & Haynes, D. (2010). Inhibition of apoptosis in periodontitis. Journal of Dental Research, 89(1), 29-33. DOI Scopus46 WoS40 Europe PMC31
2010	Bhadang, K., Holding, C., Thissen, H., McLean, K., Forsythe, J., & Haynes, D. (2010). Biological responses of human osteoblasts and osteoclasts to flame-sprayed coatings of hydroxyapatite and fluorapatite blends. Acta Biomaterialia, 6(4), 1575-1583. DOI Scopus50 WoS45 Europe PMC14
2009	Lacey, D., De Kok, B., Clanchy, F., Bailey, M., Speed, K., Haynes, D., . . . Hamilton, J. (2009). Low dose metal particles can induce monocyte/macrophage survival. Journal of Orthopaedic Research, 27(11), 1481-1486. DOI Scopus12 WoS6 Europe PMC6
2009	Vincent, C., Findlay, D., Welldon, K., Wijenayaka, A., Zheng, T., Haynes, D., . . . Atkins, G. (2009). Pro-inflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNF alpha induce the mitogen-activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts. Journal of Bone and Mineral Research, 24(8), 1434-1449. DOI Scopus149 WoS145 Europe PMC101
2009	Atkins, G., Welldon, K., Holding, C., Haynes, D., Howie, D., & Findlay, D. (2009). The induction of a catabolic phenotype in human primary osteoblasts and osteocytes by polyethylene particles. Biomaterials, 30(22), 3672-3681. DOI Scopus85 WoS80 Europe PMC68
2009	Cantley, M., Bartold, P., Marino, V., Reid, R., Fairlie, D., Wyszynski, R., . . . Haynes, D. (2009). The use of live-animal micro-computed tomography to determine the effect of a novel phospholipase A₂ inhibitor on alveolar bone loss in an in vivo mouse model of periodontitis. Journal of Periodontal Research, 44(3), 317-322. DOI Scopus21 WoS17 Europe PMC16
2009	Dharmapatni, A., Smith, M., Findlay, D., Holding, C., Evdokiou, A., Ahern, M., . . . Haynes, D. (2009). Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium. Arthritis Research & Therapy, 11(1), R13:1-R13:11. DOI Scopus49 WoS52 Europe PMC39
2009	Cantley, M., Smith, M., & Haynes, D. (2009). Pathogenic bone loss in rheumatoid arthritis: Mechanisms and therapeutic approaches. International Journal of Clinical Rheumatology, 4(5), 561-582. DOI Scopus15
2008	Haynes, D., Crotti, T., Weedon, H., Slavotinek, J., Au, V., Coleman, M., . . . Smith, M. (2008). Modulation of RANKL and osteoprotegerin expression in synovial tissue from patients with rheumatoid arthritis in response to disease-modifying antirheumatic drug treatment and correlation with radiologic outcome. Arthritis and Rheumatism, 59(7), 911-920. DOI Scopus37 WoS33 Europe PMC26
2008	Shimamura, Y., Holding, C., Haynes, D., Vernon-Roberts, B., Blumbergs, P., Fraser, R., & Moore, R. (2008). The biologic response to particles from a potential disc prosthesis material. Spine, 33(4), 351-355. DOI Scopus4 WoS4 Europe PMC4
2007	Haynes, D. (2007). Inflammatory cells and bone loss in rheumatoid arthritis. Arthritis Research & Therapy, 9(3), 3 pages. DOI Scopus22 WoS19 Europe PMC14
2006	Haynes, D. (2006). Emerging and future therapies for the treatment of bone loss associated with chronic inflammation. Inflammopharmacology, 14(5-6), 193-197. DOI Scopus20 Europe PMC13
2006	Holding, C., Findlay, D., Stamenkov, R., Neale, S., Lucas, H., Dharmapatni, A., . . . Haynes, D. (2006). The correlation of RANK, RANKL and TNFα expression with bone loss volume and polyethylene wear debris around hip implants. Biomaterials, 27(30), 5212-5219. DOI Scopus109 WoS98 Europe PMC72
2005	Krisstiansson, P., Holding, C., Hughes, S., & Haynes, D. (2005). Does human relaxin-2 affect peripheral blood mononuclear cells to increase inflammatory mediators in pathologic bone loss?. Annals of the New York Academy of Sciences, 1041(1), 317-319. DOI Scopus9 Europe PMC9
2005	Findlay, D., & Haynes, D. (2005). Mechanisms of bone loss in rheumatoid arthritis. Modern Rheumatology, 15(4), 232-240. DOI Scopus46 Europe PMC29
2005	Ramaswamy, Y., Haynes, D., Berger, G., Gildenhaar, R., Lucas, H., Holding, C., & Zreiqat, H. (2005). Bioceramics composition modulate resorption of human osteoclasts. Journal of Materials Science-Materials in Medicine, 16(12), 1199-1205. DOI Scopus35 WoS34 Europe PMC15
2005	Bartold, P., Marshall, R., & Haynes, D. (2005). Periodontitis and rheumatoid arthritis: a review. Journal of Periodontology, 76(11S), 2066-2074. DOI Scopus235 WoS195 Europe PMC103
2005	Zannettino, A., Holding, C., Diamond, P., Atkins, G., Kostakis, P., Farrugia, A., . . . Haynes, D. (2005). Osteoprotegerin (OPG) is localized to the Weibel-Palade bodies of human vascular endothelial cells and is physically associated with von Willebrand factor. Journal of Cellular Physiology, 204(2), 714-723. DOI Scopus142 WoS141 Europe PMC96
2005	Walker, J., Stirling, J., Beroukas, D., Dharmapatni, A., Haynes, D., Smith, M., . . . Roberts-Thomson, P. (2005). Histopathological and ultrastructural features of dermal telangiectasias in systemic sclerosis. Pathology, 37(3), 220-225. DOI Scopus30 WoS26 Europe PMC15
2005	Bartold, P., Marshall, R., & Haynes, D. (2005). Periodontitis and Rheumatoid Arthritis: A Review.. Journal of periodontology, 76 Suppl 11S, 2066-2074. DOI Europe PMC49
2004	Haynes, D., & Crotti, T. (2004). Regulation of osteoclast activity in peri-implant tissues. Biomaterials, 25(20), 4877-4885. DOI Scopus71 WoS58 Europe PMC42
2004	Haynes, D. (2004). Bone lysis and inflammation. Inflammation Research, 53(11), 596-600. DOI Scopus55 WoS49 Europe PMC41
2004	Crotti, T., Smith, M., Findlay, D., Zreiqat, H., Ahern, M., Weedon, H., . . . Haynes, D. (2004). Factors regulating osteoclast formation in human tissues adjacent to peri-implant bone loss: expression of receptor activator NF[kappa]B, RANK ligand and osteoprotegerin. Biomaterials, 25(4), 565-573. DOI Scopus138 WoS124 Europe PMC103
2003	Haynes, D., & Crotti, T. (2003). Regulation of bone lysis in inflammatory diseases. Inflammopharmacology, 11(4-6), 323-331. DOI Scopus6 Europe PMC5
2003	Zreiqat, H., Crotti, T., Howlett, C., Capone, M., Markovic, B., & Haynes, D. (2003). Prosthetic particles modify the expression of bone-related protiens by human osteoblastic cells in vitro. Biomaterials, 24(2), 337-346. DOI Scopus30 WoS26 Europe PMC21
2003	Crotti, T., Ahern, M., Lange, K., Weedon, H., Coleman, M., Roberts-Thomson, P., . . . Smith, M. (2003). Variability of RANKL and osteoprotegerin staining in synovial tissue from patients with active rheumatoid arthritis: Quantification using color video image analysis. Journal of Rheumatology, 30(11), 2319-2324. Scopus23 WoS20 Europe PMC13
2003	Haynes, D., Barg, E., Crotti, T., Holding, C., Weedon, H., Atkins, G., . . . Smith, M. (2003). Osteoprotegerin expression in synovial tissue from patients with rheumatoid arthritis, spondyloarthropathies and osteoarthritis and normal controls. Rheumatology, 42(1), 123-134. DOI Scopus135 WoS122 Europe PMC92
2003	Zreiqat, H., Akin, F., Howlett, C., Markovic, B., Haynes, D., Lateef, S., & Hanley, L. (2003). Differentiation of human bone-derived cells grown on GRGDSP-peptide bound titanium surfaces. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 64A(1), 105-113. DOI Scopus74 WoS61 Europe PMC36
2003	Crotti, T., Smith, M., Hirsch, R., Soukoulis, S., Weedon, H., Capone, M., . . . Haynes, D. (2003). Receptor activator NF kB ligand (RANKL) and osteoprotegerin (OPG) protein expression in periodontitis. Journal of Periodontal Research, 38(4), 380-387. DOI Scopus247 WoS223 Europe PMC174
2002	Atkins, G., Bouralexis, S., Evdokiou, A., Hay, S., Labrinidis, A., Zannettino, A., . . . Findlay, D. (2002). Human osteoblasts are resistant to Apo2L/TRAIL-mediated apoptosis. Bone, 31(4), 448-456. DOI Scopus60 WoS60 Europe PMC38
2002	Crotti, T., Smith, M., Weedon, H., Ahern, M., Findlay, D., Kraan, M., . . . Haynes, D. (2002). Receptor activator NFκB ligand (RANKL) expression in synovial tissue from patients with rheumatoid arthritis, spondyloarthropathy, osteoarthritis, and from normal patients: semiquantitative and quantitative analysis. Annals of the Rheumatic Diseases, 61(12), 1047-1054. DOI Scopus171 WoS153 Europe PMC118
2002	Moore, R., Fraser, R., Vernon-Roberts, B., Finnie, J., Blumbergs, P., Haynes, D., . . . Koszyca, B. (2002). The biologic response to particles from a lumbar disc prosthesis. Spine, 27(19), 2088-2094. DOI Scopus31 WoS25 Europe PMC18
2002	Atkins, G., Haynes, D., Zannettino, A., Capone, M., Crotti, T., & Findlay, D. (2002). Haemopoietic cells influence stromal cell gene expression during human osteoclast development. Journal of Bone and Joint Surgery - British Volume, 84B(Suppl.3), 235.
2002	Atkins, G., Crotti, T., Loric, M., Findlay, D., Howie, D., Bain, G., & Haynes, D. (2002). Periprosthetic osteolysis is associated with wear particles stimulating factors that control osteoclast formation. Journal of Bone and Joint Surgery - British Volume, 84B(Suppl.3), 234.
2002	Atkins, G., Crotti, T., Loric, M., Findlay, D., Smith, M., & Haynes, D. (2002). Osteolysis in bone loss pathologies is associated with similar factors that control osteoclast formation. Asia Pacific Orthopaedic Association.. Journal of Bone and Joint Surgery - British Volume, 84B(Suppl.3), 234-235.
2001	Haynes, D., Crotti, T., Loric, M., Bain, G., Atkins, G., & Findlay, D. (2001). Osteoprotegerin and receptor activator of nuclear factor kappaB ligand (RANKL) regulate osteoclast formation by cells in the human rheumatoid arthritic joint. Rheumatology, 40(6), 623-630. DOI Scopus187 WoS165 Europe PMC121
2001	Haynes, D., Crotti, T., Potter, A., Loric, M., Atkins, G., Howie, D., & Findlay, D. (2001). The osteoclastogenic molecules RANKL and RANK are associated with periprosthetic osteolysis. Journal of Bone and Joint Surgery-British Volume, 83B(6), 902-911. DOI Scopus166 WoS137 Europe PMC100
2001	Atkins, G., Bouralexis, S., Haynes, D., Graves, S., Geary, S., Evdokiou, A., . . . Findlay, D. (2001). Osteoprotegerin inhibits osteoclast formation and bone resorbing activity in giant cell tumors of bone. Bone, 28(4), 370-377. DOI Scopus85 WoS82 Europe PMC54
2001	Dalidjan, M., Pierce, A. M., Wilson, D. F., Crotti, T. N., Capone, M., & Haynes, D. R. (2001). The presence of regulators of osteoclast formation in periodontal disease.. JOURNAL OF DENTAL RESEARCH, 80(4), 978.
2001	Crotti, T. N., Smith, M. D., Weedon, H., Capone, M., Holding, C., Findlay, D. M., & Haynes, D. R. (2001). Osteoprotegerin (OPG) and RANKL expression in tissues near bone in diseases of pathological bone loss: A comparison of rheumatoid arthritis, prosthetic joint failure and periodontal disease.. JOURNAL OF BONE AND MINERAL RESEARCH, 16, S227. WoS1
2000	Atkins, G., Haynes, D., Graves, S., Evdokiou, A., Hay, S., Bouralexis, S., & Findlay, D. (2000). Expression of osteoclast differentiation signals by stromal elements of giant cell tumors. Journal of Bone and Mineral Research, 15(4), 640-649. DOI Scopus162 WoS163 Europe PMC113
2000	Neale, S., Haynes, D., Howie, D., Murray, D., & Athanasou, N. (2000). The effect of particle phagocytosis and metallic wear particles on osteoclast formation and bone resorption in vitro. Journal of Arthroplasty, 15(5), 654-662. DOI Scopus51 WoS47 Europe PMC35
2000	Mc Gee, M., Howie, D., Tsirgiotis, K., Haynes, D., Wildenauer, C., Pearcy, M., & McLean, J. (2000). Implant retrieval studies of the wear and loosening of prosthetic joints: a review. Wear, 241(2), 158-165. DOI Scopus96 WoS80
2000	Haynes, D., Crotti, T., & Haywood, M. (2000). Corrosion of and changes in biological effects of cobalt chrome alloy and 316L staianless steel prosthetic particles with age. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 49(2), 167-175. DOI Scopus72 WoS69 Europe PMC26
2000	Haynes, D., Harkin, D., Bignold, L., Hutchens, M., Taylor, S., & Fairlie, D. (2000). Inhibition of C5a-induced neutrophil chemotaxis and macrophage cytokine production In vitro by a new C5a receptor antagonist. Biochemical Pharmacology, 60(5), 729-733. DOI Scopus56 WoS54 Europe PMC34
2000	Atkins, G., Haynes, D., Geary, S., Loric, M., Crotti, T., & Findlay, D. (2000). Coordinated cytokine expression by stromal and hematopoietic cells during human osteoclast formation. Bone, 26(6), 653-661. DOI Scopus70 WoS65 Europe PMC43
1999	Haynes, D., Atkins, G., Loric, M., Crotti, T., Geary, S., & Findlay, D. (1999). Bidirectional signaling between stromal and hemopoietic cells regulates interleukin-1 expression during human osteoclast formation. Bone, 25(3), 269-278. DOI Scopus40 WoS34 Europe PMC25
1999	Atkins, G. J., Haynes, D. R., Graves, S. E., Evdokiou, A., Hay, S., Bouralexis, S., . . . Findlay, D. M. (1999). Expression of osteoclast differentiation signals by stromal elements of giant cell tumours.. JOURNAL OF BONE AND MINERAL RESEARCH, 14, S176. WoS1
1998	Pierce, A. M., Haynes, D. R., Loric, M., Findlay, D., Dreyer, C., & Vernon-Roberts, B. (1998). The use of animal and human model systems to study tooth and bone resorption <i>in vitro</i>.. JOURNAL OF DENTAL RESEARCH, 77, 721.
1998	Haynes, D., Hutchens, M., Whitehouse, M., & Vernon-Roberts, B. (1998). A comparison of the disease-modifying and cytokine-regulating activities of tenidap, piroxicam and cyclosporin-A using the adjuvant-induced model of arthritis in rats. Inflammopharmacology, 6(3), 193-202. DOI Scopus3 Europe PMC2
1998	Pentilla, I., Harris, R., Storm, P., Haynes, D., Worswick, D., & Marmion, B. (1998). Cytokine dysregulation in the post-Q-fever fatigue syndrome. QJM, 91(8), 549-560. DOI Scopus88 WoS75 Europe PMC51
1998	Haynes, D., Boyle, S., Rogers, S., Howie, D., & Vernon-Roberts, B. (1998). Variation in cytokines induced by particles from different prosthetic materials. Clinical Orthopaedics and Related Research, 352(352), 223-230. DOI Scopus104 WoS93 Europe PMC8
1997	McGee, M., Howie, D., Neale, S., Haynes, D., & Pearcy, M. (1997). The role of polyethylene wear in joint replacement failure. Proceedings of the Institution of Mechanical Engineers, Part H, 211(1), 65-72. DOI Scopus50 WoS35 Europe PMC10
1997	Rogers, S., Howie, D., Graves, S., Pearcy, M., & Haynes, D. (1997). In vitro human monocyte response to wear particles of titanium alloy containing vanadium or niobium. Journal of Bone and Joint Surgery (British), 79-B(2), 311-315. DOI Scopus149 WoS136 Europe PMC61
1997	Haynes, D., Hay, S., Rogers, S., Ohta, S., Howie, D., & Graves, S. (1997). Regulation of bone cells by particle-activated mononuclear phagocytes. Journal of Bone and Joint Surgery, 79B(6), 988-994. DOI Scopus66 WoS57 Europe PMC38
1997	Whitehouse, M., Macrides, T., Kalafatis, N., Betts, W., Haynes, D., & Broadbent, J. (1997). Anti-inflammatory activity of a lipid fraction (lyprinol) from the NZ green-lipped mussel. Inflammopharmacology, 5(3), 237-246. DOI Scopus121
1997	Youssef, P., Haynes, D., Triantafillou, S., Parker, A., Gamble, J., Roberts-Thomson, P., . . . Smith, M. (1997). Effects of pulse methylprednisolone on inflammatory mediators in peripheral blood, synovial fluid, and synovial membrane in rheumatoid arthritis. Arthritis and Rheumatism, 40(8), 1400-1408. DOI Scopus111 WoS109 Europe PMC74
1996	Howie, D., Rogers, S., McGee, M., & Haynes, D. (1996). Biologic effects of cobalt chrome in cell and animal models. Clinical Orthopaedics and Related Research, 329(Suppl), S217-S232. DOI Scopus113 WoS39 Europe PMC18
1996	Haynes, D., Rogers, S., Howie, D., Pearcy, M., & Vernon-Roberts, B. (1996). Drug inhibition of the macrophage response to metal wear particles in vitro. Clinical Orthopaedics and Related Research, 323(323), 316-326. DOI Scopus48 WoS22 Europe PMC3
1996	Haynes, D., & Vernon-Roberts, B. (1996). Prospects for non-surgical intervention in artificial joint loosening. Journal of Orthopaedic Rheumatology, 9(2), 74-77.
1996	Haynes, D., Gadd, S., Whitehouse, M., Mayrhofer, G., & Vernon-Roberts, B. (1996). Complete prevention of the clinical expression of adjuvant-induced arthritis in rats by cyclosporin-A and lobenzarit: the regulation of lymph node cell populations and cytokine production. Inflammation Research, 45(4), 159-165. DOI Scopus15 WoS10 Europe PMC9
1995	Haynes, D., & Vernon-Roberts, B. (1995). Potential pharmacological treatments of prosthetic joint loosening. Inflammopharmacology, 3(3), 213-219. DOI Scopus4
1994	Rofe, A. M., Philcox, J. C., Haynes, D. R., & Coyle, P. (1994). Wasting in adjuvant-induced arthritis and its relationship to plasma zinc, copper and liver metallothionein. Agents and Actions, 42(1-2), 60-62. DOI Scopus9 Europe PMC4
1994	Wright, P. F. A., Stacey, N. H., & Haynes, D. R. (1994). Effects of piroxicam and misoprostol on cytokine release from human liver immune cells. In Vitro Toxicology: Journal of Molecular and Cellular Toxicology, 7(2), 113-118.
1993	Howie, D. W., Haynes, D. R., Rogers, S. D., McGee, M. A., & Pearcy, M. J. (1993). The response to particulate debris. Orthopedic Clinics of North America, 24(4), 571-581. Scopus134 WoS118 Europe PMC43
1993	Haynes, D. R., Rogers, S. D., Hay, S., Pearcy, M. J., & Howie, D. W. (1993). The differences in toxicity and release of bone-resorbing mediators induced by titanium and cobalt-chromium-alloy wear particles. Journal of Bone and Joint Surgery - Series A, 75(6), 825-834. DOI Scopus376 WoS342 Europe PMC121
1993	Haynes, D. R., Wright, P. F. A., Gadd, S. J., Whitehouse, M. W., & Vernon-Roberts, B. (1993). Is aspirin a prodrug for antioxidant and cytokine-modulating oxymetabolites. Agents and Actions, 39(1-2), 49-58. DOI Scopus36 Europe PMC27
1993	Rogers, S. D., Pearcy, M. J., Hay, S. J., Haynes, D. R., Bramley, A., & Howie, D. W. (1993). A method for production and characterization of metal prosthesis wear particles. Journal of Orthopaedic Research, 11(6), 856-864. DOI Scopus32 WoS30 Europe PMC11
1992	Haynes, D. R., Whitehouse, M. W., & Vernon-Roberts, B. (1992). The prostaglandin E<inf>1</inf> analogue, Misoprostol, regulates inflammatory cytokines and immune functions in vitro like the natural prostaglandins E<inf>1</inf>, E<inf>2</inf> and E<inf>3</inf>. Immunology, 76(2), 251-257. Scopus115 Europe PMC74
1992	Rofe, A. M., Philcox, J. C., Haynes, D. R., Whitehouse, M. W., & Coyle, P. (1992). Changes in plasma zinc, copper, iron, and hepatic metallothionein in adjuvant-induced arthritis treated with cyclosporin. Biological Trace Element Research, 34(3), 237-248. DOI Scopus22 Europe PMC17
1991	Haynes, D. R., Whitehouse, M. W., & Vernon-Roberts, B. (1991). The effects of some anti-arthritic drugs and cytokines on the shape and function of rodent macrophages. International Journal of Experimental Pathology, 72(1), 9-22. Scopus11 Europe PMC4
1991	Bartold, P. M., & Haynes, D. R. (1991). Interleukin‐6 production by human gingival fibroblasts. Journal of Periodontal Research, 26(4), 339-345. DOI Scopus114 WoS114 Europe PMC94
1990	Rofe, A. M., Whitehouse, M. W., Bourgeois, C. S., Haynes, D. R., & Vernon‐Roberts, B. (1990). Prevention of adjuvant‐induced cachexia in rats by cyclosporin A. Immunology and Cell Biology, 68(1), 63-69. DOI Scopus12 Europe PMC8
1990	Bignold, L. P., Ferrante, A., & Haynes, D. R. (1990). Studies of chemotactic, chemotactic movement-inhibiting and random movement-inhibiting effects of interleukin-1 alpha and beta, tumour necrosis factors alpha and beta and interferon gamma on human neutrophils in assays using 'sparse-pore' polycarbonate (Nuclepore) membranes in the boyden chamber. International Archives of Allergy and Immunology, 91(1), 1-7. DOI Scopus17 WoS20 Europe PMC9
1990	Haynes, D. R., Wright, P. F., Whitehouse, M. W., & Vernon‐Roberts, B. (1990). The cyclo‐oxygenase inhibitor, Piroxicam, enhances cytokine‐induced lymphocyte proliferation in vitro and in vivo. Immunology and Cell Biology, 68(4), 225-230. DOI Scopus13 Europe PMC14
1989	Smith, M. D., Haynes, D. R., & Roberts-Thomson, P. J. (1989). Interleukin 2 and interleukin 2 inhibitors in human serum and synovial fluid. I. Characterization of the inhibitor and its mechanism of action. Journal of Rheumatology, 16(2), 149-157. Scopus7 Europe PMC5
1989	Bartold, P. M., Haynes, D. R., & Vernon‐Roberts, B. (1989). Effect of mitogen and lymphokine stimulation on proteoglycan synthesis by lymphocytes. Journal of Cellular Physiology, 140(1), 82-90. DOI Scopus20 WoS23 Europe PMC12
1988	Haynes, D. R., Garrett, I. R., & Vernon-Roberts, B. (1988). Effect of gold salt treatment on the receptor binding activity of monocytes and macrophages isolated from rats with adjuvant arthritis. Rheumatology International, 8(4), 159-164. DOI Scopus9 Europe PMC10
1988	Haynes, D. R., Garrett, I. R., Whitehouse, M. W., & Vernon-Roberts, B. (1988). Do gold drugs inhibit interleukin-1? Evidence from an in vitro lymphocyte activating factor assay. Journal of Rheumatology, 15(5), 775-778. Scopus20 Europe PMC15
1984	Manning, P. A., & Haynes, D. R. (1984). A common-immunogenic Vibrio outer membrane protein. FEMS Microbiology Letters, 24(2-3), 297-302. DOI Scopus16
1982	Manning, P. A., Imbesi, F., & Haynes, D. R. (1982). Cell envelope proteins in Vibrio cholerae. FEMS Microbiology Letters, 14(3), 159-166. DOI Scopus30

Books

Year	Citation
2000	Haynes, D., Crotti, T., Loric, M., Atkins, G., Howie, D., Vernon-Roberts, B., & Findlay, D. (2000). Osteoclastogenic factors associated with periprosthetic osteolysis. USA.
2000	Crotti, T., Loric, M., Dalidjan, M., Atkins, G., Findlay, D., Howie, D., & Haynes, D. (2000). Expression of RANK, RANKL and OPG is associated with rheumatoid arthritic, periodontal and periprosthetic tissues. USA.
2000	Zreiqat, H., Howlett, C., Markovic, B., Loric, M., Crotti, T., & Haynes, D. (2000). The Mechanisms by Which Metallic Particles Influence The In Vitro Expression of Osteogenic mRNAs and Proteins from Human Bone-Derived Cells. USA.

Book Chapters

Year	Citation
2006	Findlay, D., & Haynes, D. (2006). Bone resorption. In Wiley encyclopedia of biomedical engineering (pp. www1-www13). Hoboken, N.J: Wiley. DOI
2006	Haynes, D., & Crotti, T. (2006). Cytokines and mediators in physiologic and pathologic bone resorption. In A. Shanbhag, H. Rubash, & J. Jacobs (Eds.), Joint replacement and bone resorption - pathology, biomaterials, and clinical practice (1 ed., pp. 281-325). USA, UK: Taylor & Francis. DOI Scopus1
1996	Rogers, S., Howie, D., Haynes, D., & Pearcy, M. (1996). The In Vitro Response to Particulate Titanium Alloy. In Medical Applications of Titanium and its Alloys: The Material and Biological Issues (Vol. 1272, pp. 297-305). American Society for Testing and Materials. Scopus3

Conference Papers

Year	Citation
2011	Dharmapatni, A., Fitzpatrick, D., Cantley, M. D., & Haynes, D. R. (2011). INCREASED SOFAT MRNA EXPRESSION DURING OSTEOCLAST DEVELOPMENT, EVIDENCE THAT SOFAT IS NOT ONLY ASSOCIATED WITH T CELLS. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S604). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD.
2011	Atkins, G. J., Vincent, C., Wijenayaka, A. R., Welldon, K. J., Haynes, D. R., Zheng, T. S., . . . Findlay, D. M. (2011). THE EFFECTS OF TWEAK AND TNF ON HUMAN OSTEOBLASTS: MAPK DEPENDENT INDUCTION OF SCLEROSTIN EXPRESSION. In D. Wallach, A. Kovalenko, & M. Feldman (Eds.), ADVANCES IN TNF FAMILY RESEARCH Vol. 691 (pp. 688). San Lorenzo del Escorial, SPAIN: SPRINGER-VERLAG BERLIN.
2011	Crotti, T. N., Zawawi, M. S., Dharmapatni, A. A., Cantley, M. D., & Haynes, D. R. (2011). INHIBITION OF ITAM ADAPTOR MOLECULES AND THEIR RECEPTORS BY INHIBITION OF CALCINEURIN-NFAT SIGNALLING DURING LATE STAGE HUMAN OSTEOCLAST DIFFERENTIATION. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S603). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD.
2011	Dharmapatni, A. A. S., Gillard, J. W., Rainsford, K. D., & Haynes, D. R. (2011). REGULATION OF HUMAN OSTEOCLAST ACTIVITY AND APOPTOSIS BY IAP INHIBITORS IN VITRO. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S603-S604). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD.
2011	Cantley, M. D., Fairlie, D. P., Bartold, P., Marino, V., & Haynes, D. R. (2011). INHIBITING HISTONE DEACETYLASES EXPRESSED IN HUMAN PERIODONTAL TISSUES PREVENTS BONE LOSS IN AN ANIMAL MODEL OF PERIODONTAL DISEASE. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S613). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD.
2010	Haynes, D. R., Dharmapatni, K., Smith, M. D., Chen, D. Y., Holding, C. A., Weedon, H., & Upton, A. (2010). A ROLE FOR TNF-LIKE WEAK INDUCER OF APOPTOSIS (TWEAK) DERIVED FROM SYNOVIAL TISSUES AND CARTILAGE IN THE PATHOGENESIS OF OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 18 (pp. S100). Brussels, BELGIUM: W B SAUNDERS CO LTD. DOI
2010	Cantley, M., Haynes, D. R., & Rainsford, K. D. (2010). EFFECTS OF RIBONUCLEINATE COMPONENTS OF OSTEOCHONDRIN<SUP>R</SUP> S OSTEOARTHRITIS THERAPY ON FORMATION AND ACTIVITY OF HUMAN OSTEOCLASTS <i>IN VITRO</i>. In OSTEOARTHRITIS AND CARTILAGE Vol. 18 (pp. S254-S255). Brussels, BELGIUM: W B SAUNDERS CO LTD. DOI WoS1
2009	Wijenayaka, A. R., Vincent, C., Findlay, D. M., Welldon, K. J., Zheng, T. S., Haynes, D. R., . . . Atkins, G. J. (2009). The proinflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFa induce the mitogen activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts. In BONE Vol. 44 (pp. S63). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC. DOI WoS1
2009	Welldon, K. J., Holding, C., Haynes, D. R., Howie, D. W., Findlay, D. M., & Atkins, G. J. (2009). Polyethylene particles activate pro-osteoclastogenic signalling pathways in human primary osteoblasts and osteocytes. In BONE Vol. 44 (pp. S127-S128). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC. DOI
2009	Cantley, M. D., Fairlie, D. P., Bartold, M. P., Rainsford, K. D., & Haynes, D. R. (2009). Inhibition of both class I and class II histone deacetylases is required to effectively inhibit osteoclast bone resorption in vivo and in vitro. In BONE Vol. 44 (pp. S133-S134). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC. DOI WoS1
2008	Atkins, G. J., Vincent, C., Wijenayaka, A. R., Welldon, K. J., Haynes, D. R., Zheng, T. S., . . . Findlay, D. M. (2008). The Proinflammatory Cytokine TWEAK Induces Sclerostin Expression in Human Immature Osteoblasts in a MAPK Dependent Fashion.. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 23 (pp. S385). Montreal, CANADA: AMER SOC BONE & MINERAL RES.
2007	Atkins, G. J., Vincent, C., Welldon, K. J., Haynes, D. R., Holding, C., Zheng, T. S., . . . Findlay, D. M. (2007). TWEAK is a regulator of human osteoblast function. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 22 (pp. S138). Honolulu, HI: AMER SOC BONE & MINERAL RES.
2006	Ramaswamy, W., Ben-Nissan, B., Roest, R., Haynes, D., & Zreiqat, H. (2006). Human osteoclasts behaviour on sol-gel derived carbonate hydroxyapatite coatings on anodized titanium alloy substrates. In Key Engineering Materials Vol. 309-311 I (pp. 709-712). Trans Tech Publications Ltd.. DOI Scopus3
2005	Dharmapatni, A. A. S. S. K., Findlay, D. M., Smith, M. D., Evdokiou, A., Chen, P., Screaton, G. R., . . . Haynes, D. R. (2005). Regulating the sensitivity of synovial fibroblasts to trail-induced apoptosis. In ANNALS OF THE RHEUMATIC DISEASES Vol. 64 (pp. 154). Vienna, AUSTRIA: BMJ PUBLISHING GROUP.
2004	Lucas, H., Zreiqat, H., Gross, K. A., Holding, C., Findlay, D. M., Wallwork, M., & Haynes, D. R. (2004). Osteoclast resorption of hydroxyapatite bone substitute materials in vitro. In Transactions - 7th World Biomaterials Congress (pp. 1309).
2004	Peters, K., Haynes, D. R., Crotti, T. N., Unger, R. E., & Kirkpatrick, C. J. (2004). Effects of wear particles from metallic implant materials on the pro-inflammatory state of endothelial cells in vitro. In Transactions - 7th World Biomaterials Congress (pp. 1150).
1999	Atkins, G. J., Loric, M., Crotti, T. N., Haynes, D. R., & Findlay, D. M. (1999). Osteoclast differentiation factors are expressed by both stromal and haematopoietic cells in human osteoclast formation. In H. Stein, S. I. Suk, P. C. Leung, K. G. Thorngren, & W. Akeson (Eds.), SIROT 99 (pp. 547-551). SYDNEY, AUSTRALIA: FREUND PUBL HOUSE LTD.
1999	Crotti, T. N., Potter, A. E., Atkins, G. J., Findlay, D. M., Howie, D. W., & Haynes, D. R. (1999). Osteoclast differentiation and development is regulated by mediators released in response to prosthetic particles. In H. Stein, S. I. Suk, P. C. Leung, K. G. Thorngren, & W. Akeson (Eds.), SIROT 99 (pp. 542-546). SYDNEY, AUSTRALIA: FREUND PUBL HOUSE LTD.

Conference Items

Year	Citation
2016	Crotti, T. N., Coleman, R., Dharmapatni, A. A., Weedon, H., Haynes, D. R., Smith, M. D., & Wechalekar, M. D. (2016). EXPRESSION OF OSCAR IN THE SYNOVIUM OF EARLY RA PATIENTS. Poster session presented at the meeting of ANNALS OF THE RHEUMATIC DISEASES. London, ENGLAND: BMJ PUBLISHING GROUP. DOI
2014	Dharmapatni, A., Cantley, M., Marino, V., Perilli, E., Crotti, T., Smith, M., & Haynes, D. (2014). THE X-LINKED INHIBITORY OF APOPTOSIS PROTEIN INHIBITOR, EMBELIN SUPPRESSES INFLAMMATION AND BONE EROSION IN COLLAGEN ANTIBODY INDUCED ARTHRITIS (CAIA) MICE. Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY-BLACKWELL.
2013	Dharmapatni, A., Coleman, R., Lorimer, M., Zannettino, A., Weedon, H., Wechalekar, M., . . . Crotti, T. (2013). Relationship between Soluble OSCAR and Disease Activity: A 12 Month Study of Newly Diagnosed RA Patients. Poster session presented at the meeting of JOURNAL OF BONE AND MINERAL RESEARCH. Baltimore, MD: WILEY-BLACKWELL.
1998	Irani, D. M., Pierce, A. M., Gully, N. J., Haynes, D. R., & Wilson, D. F. (1998). <i>Eikenella corrodens</i> surface associated material stimulates osteolytic cytokines.. Poster session presented at the meeting of JOURNAL OF DENTAL RESEARCH. AMER ASSOC DENTAL RESEARCH.
1998	Irani, D. M., Pierce, A. M., Haynes, D. R., Gully, N. J., & Wilson, D. F. (1998). <i>Eikenella corrodens</i> surface associated material stimulates osteolytic cytokines.. Poster session presented at the meeting of JOURNAL OF DENTAL RESEARCH. SAGE PUBLICATIONS INC.

Date	Project/ No.	Investigators	Funding Body	Amount
1991-1994	Arthritis : Mechanisms of initiation and their modulation by drugs. / #31264	Vernon-Roberts B, Whitehouse MW, Haynes DR	NHMRC	$238622
1994	Wear particle induced bone resorption causing joint replacement loosening. / #31965	Howie DW, Vernon-Roberts B, Haynes DR	NHMRC	$133454
1994	Arthritis: Manipulating endogenous mediators to optimise treatment. / #32432	Vernon-Roberts B, Whitehouse MW, Haynes DR	NHMRC	$60,152
1996-1998	Cell biology and drug control of loosening of joint prostheses. / #34313	Vernon-Roberts B, Howie DW, Haynes DR, Graves SE	NHMRC	$161100
1998-2000	Requirements for human osteoclast generation. / #35252	Findlay DM, Haynes DR, Howie DW	NHMRC	$166,000
2000-2002	Cell regulation of periprosthetic bone loss. / #104818*	Haynes DR, Findlay DM, Vernon-Roberts B, Howie DW	NHMRC	$318,630
2001-2003	Requirements for human osteoclast generation. / #157984	Findlay DM, Atkins GJ, Haynes DR, Zannetino A	NHMRC	$273,000
2003-2005	Mechanisms of periprosthetic bone loss. / #250344	Findlay DM, Haynes DR, Howie DW, McGee MA	NHMRC	$315,000
2005-2007	Improving orthopaedic/dental devices by surface chemical modification / #DP0556403	Zreiqat H, Swain MV, Haynes DR, Anderson G	ARC	$555,000
2004-2006	Regulation of bone resorption in periodontal disease. / #299028	Haynes DR, Bartold PM, Findlay DM, Gully NJ	NHMRC	$254,750
2004-2006	Inducing normal bone remodelling at the medical device/ bone interface. / #300487	Zreiqat H , Haynes DR	NHMRC	$468,250
2006 -2008	Impaired bone remodelling leads to failure of orthopaedic prostheses. / #399168	Findlay DM, Haynes DR, Howie DW, Atkins GJ, Crotti TN	NHMRC	$515,917
2007-2009	The role of TNF family members TWEAK and TNF-alpha in bone remodelling./ #453605	Atkins GJ, Findlay DM, Haynes DR, Zheng TS, Zannetino A	NHMRC	$544,500
2007-2009	Regulation of Osteoclasts in Bone Pathologies./ #453568	Haynes DR, Bartold PM, Smith MD, Rainsford KD	NHMRC	$566,947
2009-2012	Regulation of key pathways causing peri-implant bone loss./ #565361	Haynes DR, Findlay DM, Atkins GA, Howie DW, Crotti TN	NHMRC	$536,613
2011-2013	Sclerostin effects on bone mineralisation and catabolism. / #1004871	GJ Atkins, Findlay DM, Haynes DR	NHMRC	$536,653
2012-2014	Periodontal disease and rheumatoid arthritis / #1023747	Bartold PM , Haynes DR, Smith MD, Proudman S	NHMRC	$536,128
2013-2015	Particle induced osteolysis and osteocytes / #1041456	GJ Atkins, Haynes DR, Findlay DM	NHMRC	$449,619
2014-2016	HDAC 1 and 5 in periodontitis / #1057853	Haynes DR, Bartold PM , Cantley MD	NHMRC	$518,901
2014-2017	An international network on new strategies for processing calcium phosphates.	Riga Technical University, University of Riga, Universite de Technologie de Belfort Montbeliard, University College London, Ludwig Boltzmann Gesellschaft, University de Limoges	European Community Seventh Framework Programme Grant

Teaching

Course coordinator of the compulsory second year course Biology of Disease in the Bachelor of Health Sciences program.

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2016 - 2021	Co-Supervisor	Studies on the Functions of Latent Transforming Growth Factor Beta (TGF-Beta) Binding Protein-2 (LTBP-2) in the Regulation of TGF-Beta 1 and Fibrosis Progression	Doctor of Philosophy	Doctorate	Full Time	Mr Yike You
2015 - 2020	Principal Supervisor	Osteochondroreticular Stem Cell Therapy for Osteoarthritis: The right cells for the job	Doctor of Philosophy	Doctorate	Full Time	Miss Jia Ng
2014 - 2018	Principal Supervisor	Epigenetic Regulation of Cells Involved in Periodontal Bone Destruction Through Targeted Histone Deacetylase Inhibition	Doctor of Philosophy	Doctorate	Full Time	Kent Algate
2012 - 2016	Co-Supervisor	Function of Latent Transforming Growth Factor-B Binding Protein-2 (LTBP-2) in Elastinogenesis and Modulation of Growth Factor Storage, Expression and Activity in Normal and Fibrotic Tissues	Doctor of Philosophy	Doctorate	Full Time	Mr Mohamed Arshad Mohamed Sideek
2011 - 2015	Principal Supervisor	Targeting NF-kappaB and NFATc1 signalling to inhibit bone resorption in peri-prosthetic osteolysis	Doctor of Philosophy	Doctorate	Full Time	Mr Muhamad Syahrul Fitri Zawawi
2010 - 2013	Principal Supervisor	Targeting Histone Deacetylases to Suppress Bone Loss in Similar Chronic Inflammatory Diseases, Periodontitis and Rheumatoid Arthritis.	Doctor of Philosophy	Doctorate	Full Time	Dr Melissa Cantley
2008 - 2014	Principal Supervisor	Osteoclast-associated Intracellular ITAM Signalling Molecules in Human Peri-implant Osteolysis and Rheumatoid Arthritis	Doctor of Philosophy	Doctorate	Full Time	Mr Ekram Alias
2003 - 2007	Principal Supervisor	Trail Mediated Apoptosis in Arthritis	Doctor of Philosophy	Doctorate	Full Time	Ms Anak Dharmapatni
1999 - 2002	Principal Supervisor	MEDIATORS OF LOCALISED PATHOLOGICAL BONE LOSS	Doctor of Philosophy	Doctorate	Full Time	APrf Tania Crotti
1997 - 2003	Principal Supervisor	IMMUNOGENETIC DETERMINANTS OF CHRONIC Q FEVER	Doctor of Philosophy	Doctorate	Full Time	Dr Karla Helbig

Committee Memberships

Date	Role	Committee	Institution	Country
2016 - ongoing	Member	International Combined Orthopaedic Societies for the Scientific Meeting in Xian	-	-
2007 - 2013	Member	Combined Orthopaedic Research Societies (CORS)	-	-

Memberships

Date	Role	Membership	Country
2006 - 2009	President	Australian New Zealand Orthopaedic Research Society	Australia
2003 - 2006	Secretary	Australian New Zealand Orthopaedic Research Society	Australia
1999 - 2016	Member	Australian New Zealand Bone and Mineral Society	Australia

Consulting/Advisories

Date Institution Department Organisation Type Country
2013 - 2016 Advisory Board of the Bone Foundation - - -
Editorial Boards

Date Role Editorial Board Name Institution Country
2007 - ongoing Associate Editor Inflammopharmacology - -

Date	Institution	Department	Organisation Type	Country
2013 - 2016	Advisory Board of the Bone Foundation	-	-	-

Date	Role	Editorial Board Name	Institution	Country
2007 - ongoing	Associate Editor	Inflammopharmacology	-	-

Offices Held

Date	Office Name	Institution	Country
2006 - 2013	Australian representative and committee member of The International Orthopaedic Research Societies	-	-
2006 - 2009	President of the Australian and New Zealand Society of Orthopaedic Research	-	Australia
2003 - 2006	Secretary (2003-6) of the Australian and New Zealand Society of Orthopaedic Research (www.ANZORS.org.au)	-	Australia

Email: david.haynes@adelaide.edu.au

David Haynes

Appointments

Awards and Achievements

Education

Research Interests