Dr Carlee Ruediger
Senior Trial Coordinator
Adelaide Medical School
Faculty of Health and Medical Sciences
Dr Carlee Ruediger, Clinical Researcher, Rheumatology Research Group.
Theme: Inflammatory Disease,
Her current areas of research include:
Knee pain and progression associated with osteoarthritis
Giant Cell Arteritis / Polymyalgia Rheumatica – patient directed disease outcomes and treatments
Psoriatic arthritis – patient directed disease outcomes and treatments
I am currently a clinical trial co-ordinator with expertise in trial design, protocol development, ethics submission, coordination, recruitment, and analysis. She has awarded a NHMRC-NIHR Collaborative Research Grant to set up the Australian arm of a multi centre international clinical trial into PMR. She is currently co-ordinator of two NHMRC funded randomized clinical trials of osteoarthritis (1127981, 1147370), and has coordinated three previous NHMRC funded randomized control trials (1102732, 1045415, 1048581). She is also Chief Investigator of a recently completed RCT of colchicine in hand OA; and is Chief Investigator of an on-going trial of dietary oils in osteoarthritis; each with Arthritis SA funding. Each of these trials has met recruitment targets. She has also managed multiple sponsor-led clinical trials. In addition, Dr Ruediger is co-ordinator of the SA node of the Australian Arthritis and Autoimmune Biobank Collaborative (A3BC) and the SA Giant Cell Arteritis Registry. She currently sits on the CALHN Research Ethics Committee, and contributed to the OMERACT Glucocorticoid Working Group in 2020. She has also had the opportunity to work with Arthritis SA to learn new skills in qualitative research and interviewing. Dr Ruediger has 22 co-author publications and a five first author publication. Despite a change of research direction in late 2014, and two career disruptions, she has already published 13 papers in Rheumatology, as well as presented abstracts at the ARA Annual Scientific Meeting in 2016-18 and in 2019 and was awarded a travel grant for presentations at the 2018 ARA ASM.
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Appointments
Date Position Institution name 2017 - ongoing • CALHN Human Research Ethics Committee Member SA Health 2014 - ongoing Clinical Trials Coordinator Queen Elizabeth Hospital, Adelaide 2012 - 2014 Holter / ECG Technician Cardiovascular Research Centre -
Awards and Achievements
Date Type Title Institution Name Country Amount 2014 Award Dean's Commendation for Doctoral Thesis Excellence University of Adeliade Australia - 2013 Award EO Myers Trust Fund, Travel Grant - - - 2012 Award Young Investigator Award - - - -
Language Competencies
Language Competency English Can read, write, speak, understand spoken and peer review -
Education
Date Institution name Country Title 2010 - 2014 University of Adelaide, Adelaide Australia Doctor of Philosophy 2009 University of Adelaide, Adelaide Australia Honours: Bachelor of Science (First Class) 2006 - 2008 University of Adelaide, Adelaide Australia Bachelor of Health Science
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Journals
Year Citation 2024 Lim, J., Dures, E., Bailey, L. F., Almeida, C., Ruediger, C., Hill, C. L., . . . MacKie, S. L. (2024). Jaw claudication and jaw stiffness in giant cell arteritis: secondary analysis of a qualitative research dataset. Rheumatology Advances in Practice, 8(1), 6 pages.
Scopus1 Europe PMC12023 Lyne, S. A., Ruediger, C., Lester, S., Kaur, G., Stamp, L., Shanahan, E. M., & Hill, C. L. (2023). Clinical phenotype and complications of large vessel giant cell arteritis: A systematic review and meta-analysis. Revue du Rhumatisme (Edition Francaise), 90(5), 552-564.
2023 Bridgewater, S., Shepherd, M. A., Dawson, J., Richards, P., Silverthorne, C., Ndosi, M., . . . Robson, J. C. (2023). Measuring the impact of steroid therapy on health-related quality of life in patients with rheumatic diseases: International development of a glucocorticoid treatment-specific patient-reported outcome measure. Rheumatology (United Kingdom), 62(11), 3565-3575.
Scopus3 WoS2 Europe PMC22023 Lyne, S. A., Ruediger, C., Lester, S., Kaur, G., Stamp, L., Shanahan, E. M., & Hill, C. L. (2023). Clinical phenotype and complications of large vessel giant cell arteritis: a systematic review and meta-analysis. Joint Bone Spine, 90(4), 9 pages.
Scopus6 WoS1 Europe PMC12023 Jing, Y., Su, Z., Zhang, S., Han, Q., Wang, Z., Hu, B., . . . Wu, L. (2023). Structural Characterization, Simulated Digestion and Anti-Aging Activities of an Acidic Polysaccharide from <i>Salvia Miltiorrhiza</i>. PLANT FOODS FOR HUMAN NUTRITION, 78(2), 390-398.
2023 Du, Y., Li, T., Wang, B., Zhang, S., Li, H., Zhang, H., & Zhu, Q. (2023). Experimental study on mechanical characteristics and permeability evolution during the coupled hydromechanical failure of sandstone containing a filled fissure. ACTA GEOTECHNICA, 18(8), 4055-4075.
2023 Du, Y., Zeng, Y., Li, S., Wang, Z., Su, C., Zhang, S., . . . Zhang, M. (2023). Mild infection induced by low-dose LPS does not impair follicular development and is beneficial to pregnancy in mice. FRONTIERS IN VETERINARY SCIENCE, 9, 8 pages.
2022 Li, S., Lin, J., Zhang, Y., Zhang, S., Jiang, T., Hu, Z., . . . Tian, Z. (2022). Eight-Electron Redox Cyclohexanehexone Anode for High-Rate High-Capacity Lithium Storage. ADVANCED ENERGY MATERIALS, 12(30), 11 pages.
2022 Zhu, Q., Li, T., Du, Y., Zhang, H., Ran, J., Li, W., & Zhang, S. (2022). Failure and stability analysis of deep soft rock roadways based on true triaxial geomechanical model tests. ENGINEERING FAILURE ANALYSIS, 137, 21 pages.
2022 Lyne, S. A., Ruediger, C., Lester, S., Chapman, P. T., Shanahan, E. M., Hill, C. L., & Stamp, L. (2022). Giant cell arteritis: A population-based retrospective cohort study exploring incidence and clinical presentation in Canterbury, Aotearoa New Zealand. Frontiers in Medicine, 9, 1-9.
Scopus8 WoS1 Europe PMC62022 Ruediger, C., Ninan, J., Dyer, K., Lyne, S., Tieu, J., Black, R. J., . . . Hill, C. L. (2022). Diagnosis of giant cell arteritis by temporal artery biopsy is associated with biopsy length. Frontiers in Medicine, 9, 6 pages.
Scopus3 Europe PMC22021 Davis, C. R., Ruediger, C. D., Dyer, K. A., Lester, S., Graf, S. W., Kroon, F. P. B., . . . Hill, C. L. (2021). Colchicine is not effective for reducing osteoarthritic hand pain compared to placebo: a randomised, placebo-controlled trial (COLAH). Osteoarthritis and Cartilage, 29(2), 208-214.
Scopus24 WoS11 Europe PMC112021 Zhang, S., Lu, T., Xu, P., Tao, Q., Li, M., & Lu, W. (2021). Predicting the Formability of Hybrid Organic-Inorganic Perovskites via an Interpretable Machine Learning Strategy. JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 12(31), 7423-7430.
2021 Zhou, J., Zhang, F., Chen, J., Zhang, S., & Wang, H. (2021). Chlorogenic Acid Inhibits Human Glioma U373 Cell Progression via Regulating the SRC/MAPKs Signal Pathway: Based on Network Pharmacology Analysis. DRUG DESIGN DEVELOPMENT AND THERAPY, 15, 1369-1383.
2020 He, C., Zhang, S., & Shi, L. (2020). Three-Dimensionally-Precise Breast Conformal Device for IMRT in Breast Cancer Patients Treated With Breast-Conserving Surgery-A Pilot Randomized Controlled Trial. TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 19, 9 pages.
2020 Ji, Y., Zhang, S., Qiao, M., Jiao, R., Li, J., Song, P., . . . Huang, H. (2020). Synthesis of structurally defined chondroitin sulfate: Paving the way to the structure-activity relationship studies. CARBOHYDRATE POLYMERS, 248, 11 pages.
2020 Zhang, Y., Ling, X., Su, X., Zhang, S., Wang, J., Zhang, P., . . . Tang, X. (2020). Optical Control of a CRISPR/Cas9 System for Gene Editing by Using Photolabile crRNA. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 59(47), 20895-20899.
2020 Li, C., Cao, Y., Zhang, L., Li, J., Wu, H., Ling, F., . . . Liu, C. (2020). LncRNA IGFBP4-1 promotes tumor development by activating Janus kinase-signal transducer and activator of in bladder urothelial carcinoma (Retracted Article). INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 16(13), 2271-2282.
2020 Jia, L., Wang, Y., Wang, C., Du, Z., Zhang, S., Wen, X., . . . Hu, J. -F. (2020). <i>Oplr16</i> serves as a novel chromatin factor to control stem cell fate by modulating pluripotency-specific chromosomal looping and TET2-mediated DNA demethylation. NUCLEIC ACIDS RESEARCH, 48(7), 3935-3948.
2020 Ruediger, C., Nguyen, L., Black, R., Proudman, S., & Hill, C. (2020). Efficacy of Methotrexate in Polymyalgia Rheumatica in routine rheumatology clinical care.. Internal medicine journal, 50(9), 1067-1072.
Scopus6 WoS1 Europe PMC12019 Hoon, E., Ruediger, C., Gill, T., Black, R., & Hill, C. (2019). A qualitative study of patient perspectives related to glucocorticoid therapy in polymyalgia rheumatica and giant cell arteritis. Open Access Rheumatology : Research and Reviews, 11, 189-198.
Scopus8 WoS5 Europe PMC52018 Ruediger, C., John, B., Kumar, S., Lim, H., Rangnekar, G., Roberts-Thomson, K., . . . Willoughby, S. (2018). Influence of ethnic background on left atrial markers of inflammation, endothelial function and tissue remodelling. Indian Pacing and Electrophysiology Journal, 18(1), 1-5.
Scopus22017 Black, R. J., Goodman, S. M., Ruediger, C., Lester, S., Mackie, S. L., & Hill, C. L. (2017). A survey of glucocorticoid adverse effects and benefits in rheumatic diseases: The patient perspective. Journal of Clinical Rheumatology, 23(8), 416-420.
Scopus22 WoS19 Europe PMC132016 Chen, J., Hill, C., Lester, S., Ruediger, C., Battersby, R., Jones, G., . . . March, L. (2016). Supplementation with omega-3 fish oil has no effect on bone mineral density in adults with knee osteoarthritis: a 2-year randomized controlled trial. Osteoporosis International, 27(5), 1897-1905.
Scopus23 WoS20 Europe PMC152016 Lester, S., Hewitt, A., Ruediger, C., Bradbury, L., De Smit, E., Wiese, M., . . . Hill, C. (2016). PTPN22 R620W minor allele is a genetic risk factor for giant cell arteritis. RMD Open, 2(1), e000246-1-e000246-3.
Scopus8 WoS10 Europe PMC42016 Hill, C. L., Black, R. J., Nossent, J. C., Ruediger, C., Nguyen, L., Ninan, J. V., & Lester, S. (2016). Risk of mortality in patients with giant cell arteritis: a systematic review and meta-analysis. Seminars in Arthritis and Rheumatism, 46(4), 513-519.
Scopus58 WoS52 Europe PMC282015 Wong, C., Lee, S., Gan, S., Mahajan, R., Rangnekar, G., Pathak, R., . . . Sanders, P. (2015). Underuse and overuse of anticoagulation for atrial fibrillation: a study in Indigenous and non-Indigenous Australians. International Journal of Cardiology, 191, 20-24.
Scopus25 WoS22 Europe PMC92015 Lim, H., Willoughby, S., Schultz, C., Alasady, M., Rangnekar, G., Dang, J., . . . Sanders, P. (2015). Thrombogenic risk in patients with atrial fibrillation. JACC: Clinical Electrophysiology, 1(3), 210-217.
Scopus15 Europe PMC62014 Lim, H., Willoughby, S., Schultz, C., Chakrabarty, A., Alasady, M., Lau, D., . . . Sanders, P. (2014). Successful catheter ablation decreases platelet activation and improves endothelial function in patients with atrial fibrillation. Heart Rhythm, 11(11), 1912-1918.
Scopus31 WoS25 Europe PMC182014 Lim, H., Schultz, C., Dang, J., Alasady, M., Lau, D., Brooks, A., . . . Willoughby, S. (2014). Time course of inflammation, myocardial injury, and prothrombotic response after radiofrequency catheter ablation for atrial fibrillation. Circulation: Arrhythmia and Electrophysiology, 7(1), 83-89.
Scopus137 WoS110 Europe PMC802014 Willoughby, S., Luu, L., Cameron, J., Nelson, A., Schultz, C., Worthley, S., & Worthley, M. (2014). Clopidogrel improves microvascular endothelial function in subjects with stable coronary artery disease. Heart Lung and Circulation, 23(6), 534-541.
Scopus25 WoS23 Europe PMC202014 Schultz, C., Rangneker, G., Lim, H., Fraudeau, A., Young, G., Roberts-Thomson, K., . . . Willoughby, S. (2014). Characterization of thrombogenic, endothelial and inflammatory markers in supraventricular tachycardia: a study in patients with structurally normal hearts. Clinical and Experimental Pharmacology and Physiology, 41(8), 551-557.
Scopus8 WoS5 Europe PMC82013 Lim, H., Willoughby, S., Schultz, C., Gan, C., Alasady, M., Lau, D., . . . Sanders, P. (2013). Effect of atrial fibrillation on atrial thrombogenesis in humans: Impact of rate and rhythm. Journal of the American College of Cardiology, 61(8), 852-860.
Scopus178 WoS149 Europe PMC982012 Wong, C., Lim, H., Schultz, C., Sanders, P., Worthley, M., & Willoughby, S. (2012). Assessment of endothelial function in atrial fibrillation: utility of peripheral arterial tonometry. Clinical and Experimental Pharmacology and Physiology, 39(2), 141-144.
Scopus14 WoS15 Europe PMC122011 Willoughby, S., Lau, D., Schultz, C. D., Lim, H. S., Young, G., & Sanders, P. (2011). Correlation between radial artery- and peripheral arterial-tonometry derived augmentation index in patients with atrial fibrillation. EUROPEAN HEART JOURNAL, 32, 198. 2011 Lim, H. S., Willoughby, S. R., Schultz, C., Alasady, M., Worthley, M., Young, G. D., & Sanders, P. (2011). Inflammation, Myocardial Injury and Prothrombotic Response Following Catheter Ablation for Atrial Fibrillation. journal of arrhythmia, 27(4), 269.
2010 Worthley, M., Prabhu, A., De Sciscio, P., Schultz, C., Sanders, P., & Willoughby, S. (2010). Detrimental effects of energy drink consumption on platelet and endothelial function. American Journal of Medicine, 123(2), 184-187.
Scopus122 WoS104 Europe PMC782010 Willoughby, S., Roberts-Thomson, R., Lim, H., Schultz, C., Prabhu, A., De Sciscio, P., . . . Sanders, P. (2010). Atrial platelet reactivity in patients with atrial fibrillation. Heart Rhythm, 7(9), 1178-1183.
Scopus49 WoS42 Europe PMC311976 PEARSON, J. E., SCHULTZ, C. D., RIVERS, J. E., & GONZALEZ, F. M. (1976). PESTICIDE LEVELS OF PATIENTS ON CHRONIC-HEMODIALYSIS. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 16(5), 556-558.
1967 SCHULTZ, C., & SCHMIDT, E. (1967). GALLENGANGSVERSCHLUSS UND ENZYMAKTIVITATEN IM SERUM. KLINISCHE WOCHENSCHRIFT, 45(3), 162-&.
1964 SCHULTZ, C. (1964). FETTLEBER UND CHRONISCH-ASTHMOIDE BRONCHITIS NACH INHALATION EINES FARBENLOSUNGSMITTELS ( EPICHLORHYDRIN ). DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 89(28), 1342-&.
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Conference Papers
Year Citation 2023 Ninan, J., Ruediger, C., Dyer, K. A., Dodd, T., Black, R. J., Lyne, S., . . . Hill, C. L. (2023). Incidence of biopsy-proven giant cell arteritis (GCA) in South Australia 2014–2020. In Frontiers in Medicine Vol. 10 (pp. 5 pages). Switzerland: FRONTIERS MEDIA SA.
DOI2023 Lim, J., Dures, E., Bailey, L., Almeida, C., Ruediger, C., Hill, C., . . . Mackie, S. L. (2023). JAW CLAUDICATION - DOES THE TEXTBOOK DESCRIPTION NEED UPDATING?. In RHEUMATOLOGY Vol. 62 (pp. 2 pages). ENGLAND, Manchester: OXFORD UNIV PRESS. 2022 Bridgewater, S., Shepherd, M. A., Dawson, J., Richards, P., Silverthorne, C., Ndosi, M., . . . Robson, J. C. (2022). PATIENTS' PERCEPTIONS OF GLUCOCORTICOID THERAPY IMPACT ON HEALTH-RELATED QUALITY OF LIFE DURING TREATMENT FOR RHEUMATIC DISEASES: INTERNATIONAL DEVELOPMENT OF A TREATMENT-SPECIFIC PATIENT-REPORTED OUTCOME MEASURE (THE STEROID PRO). In RHEUMATOLOGY Vol. 61 (pp. I65-+). SCOTLAND, Glasgow: OXFORD UNIV PRESS. 2021 Willers, C., Lynch, T., Chand, V., Islam, M., Lassere, M., Keen, H., . . . March, L. (2021). A Combined Patient Registry and Biobank Laboratory Information System for Prospective Multisite Chronic Rheumatic Disease Research Using REDCap. In ARTHRITIS & RHEUMATOLOGY Vol. 73 (pp. 1769-1773). ELECTR NETWORK: WILEY. 2016 Rachel, B. J., MacKie, S., Ruediger, C., & Catherine, H. L. (2016). GLUCOCORTICOID ADVERSE EFFECTS: THE PATIENT PERSPECTIVE. In INTERNAL MEDICINE JOURNAL Vol. 46 (pp. 17). WILEY-BLACKWELL. 2011 Psaltis, P. J., Harbuzariu, A., Delacroix, S., Witt, T., Kleppe, L., Mueske, C., . . . Simari, R. D. (2011). Sca-1 Identifies a Monocyte-Predisposed Hierarchy of Hematopoietic Progenitor Cells in the Postnatal Murine Aorta. In CIRCULATION Vol. 124 (pp. 1 page). LIPPINCOTT WILLIAMS & WILKINS. 2010 Delacroix, S., Boylan, B. J., Harbuzariu, A., Psaltis, P. J., Pan, S., Holroyd, E., . . . Simari, R. D. (2010). NPR-B Expression In Megakaryocytes and Platelets.. In BLOOD Vol. 116 (pp. 1751-1752). FL, Orlando: AMER SOC HEMATOLOGY. 2010 Harbuzariu, A., Psaltis, P. J., Witt, T. A., Kleppe, L. S., Delacroix, S., Holroyd, E. W., . . . Simari, R. D. (2010). Bone Marrow Mononuclear Cells Contribute to the Vascular Hematopoietic Niche. In CIRCULATION Vol. 122 (pp. 2 pages). LIPPINCOTT WILLIAMS & WILKINS. 2005 Schultz, C. D., McCallum, R. W., Sarosiek, I., Moncure, M., & Wiemers, D. (2005). Assessment of symptoms and gastric emptying in gastroesophageal reflux disease patients before and after Nissen fundoplication. In JOURNAL OF INVESTIGATIVE MEDICINE Vol. 53 (pp. S303). B C DECKER INC. -
Conference Items
Year Citation 2022 Bridgewater, S., Shepherd, M. A., Dawson, J., Richards, P., Silverthorne, C., Ndosi, M., . . . Robson, J. (2022). PATIENT PERCEPTIONS OF IMPACT OF GLUCOCORTICOID THERAPY IN THE RHEUMATIC DISEASES: INTERNATIONAL DEVELOPMENT OF A TREATMENT-SPECIFIC PATIENT REPORTED OUTCOME MEASURE. Poster session presented at the meeting of ANNALS OF THE RHEUMATIC DISEASES. DENMARK, Copenhagen: BMJ PUBLISHING GROUP.
DOI2020 Davis, C., Ruediger, C., Dyer, K., Lester, S., Graf, S., Kroon, F., . . . Hill, C. (2020). COLCHICINE IS NOT EFFECTIVE FOR REDUCING OSTEOARTHRITIC HAND PAIN COMPARED TO PLACEBO: A RANDOMISED, PLACEBO-CONTROLLED TRIAL (COLAH). Poster session presented at the meeting of INTERNAL MEDICINE JOURNAL. WILEY. 2016 Black, R., Goodman, S. M., Ruediger, C., Lester, S., Mackie, S., & Hill, C. (2016). Glucocorticoid Adverse Effects - the Patient Perspective. Poster session presented at the meeting of ARTHRITIS & RHEUMATOLOGY. DC, Washington: WILEY. 2012 Schultz, C. D., Willoughby, S. R., Kumar, S., Shenbanga, P., Nair, S. C., Srivastava, A., . . . Sanders, P. (2012). Left Atrial Inflammation and Platelet Reactivity: A Comparison of Atrial Arrhythmia and an Underlying Substrate. Poster session presented at the meeting of CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS. 2011 Lim, H. S., Willoughby, S. R., Schultz, C., Alasady, M., Lau, D. H., Roberts-Thomson, K. C., . . . Sanders, P. (2011). The Effect of Acute Onset Atrial Fibrillation and Rapid Atrial Rates on Markers of Thrombogenesis in the Human Left Atrium. Poster session presented at the meeting of journal of arrhythmia. Wiley.
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Research Funding
2021 – NHMRC - NIHR Collaborative Research Grant Scheme 2021; Catherine Hill, Helen Keen, Claire Owen, David Liew, Jo-Anne Manski-Nankervis, Nigel Stocks, Carlee Ruediger: $823,722.00
2021- Arthritis Australia- Grant in Aid, Catherine Hill, Michael Shanahan, Jem Ninan,Susan Lester, Carlee Ruediger, Suellen Lyne, The Healthcare Burden of Giant Cell Arteritis in South Australia, $10,000
2019 - Arthritis Australia Grant, 2019, Comparison of dietary oils in osteoarthritis patients: a feasibility study. Chief Investigators: Davis C, Hill CL, Ruediger C, Murphy K. One-year Grant-in-aid $15,000
2017 - Arthritis Australia Project Grant. 2017. A randomised clinical trial of colchicine in inflammatory hand osteoarthritis. Chief Investigators: Hill CL, Ruediger C. One-year project grant, co-funded by The Hospital Research Foundation. $70,000
2013 - Royal Adelaide Hospital Research Committee
Clinical Project Grant -: Dr S Willoughby, Ms C Schultz, Mr Michael Worthington, Mr James Edwards, Prof Prashanthan Sanders, Mr Robert Stuklis. Title: Platelet and Endothelial function within the atria of patients undergoing coronary artery bypass graft (CABG) surgery: Relationships with post-operative atrial fibrillation.
- Supervising Doctoral Studies Program
- University of Adelaide MBBS Program Interviewers
- 2021 SAN Mentoring program
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2021 External Supervisor Epidemiology, Clinical Phenotype and Treatment Implications of Giant Cell Arteritis in Australia and New Zealand Doctor of Philosophy Doctorate Part Time Suellen Anne Lyne
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