Bill Panagopoulos

Vasilios Panagopoulos
Adelaide Medical School
Faculty of Health and Medical Sciences

Connect With Me

Bill Panagopoulos

My career spans more than ten years of research experience within private and academic sectors focusing on cancer cell biology and tissue growth and repair. I am very passionate about cancer research and strive to identify new therapeutic strategies to combat metastatic disease. My primary research interest lies within the role of stromal cells within the tumour microenvironment on cancer growth and metastasis. This interest developed early on in my career but wasn't until my PhD (completed in 2016) where I became fascinated with targeting the stroma with novel therapeutic strategies as a treatment for breast cancer.  My PhD identified for the first time a causative role for peroxidase enzymes in cancer development and metastasis. This discovery has resulted in 3 first author publications, a patent application, and collaboration with a pharmaceutical company assessing novel peroxidase inhibitors as a potential therapeutic agents in the treatment/prevention of breast cancer. 

Appointments

Date Position Institution name
2017 Postdoctoral Research Fellow The University of Adelaide
2011 - 2016 Research Associate The University of Adelaide
2010 - 2011 Research Assistant SA Pathology
2009 - 2010 Study Coordinator VivoPharm
2008 - 2009 Research Assistant VivoPharm
2006 - 2008 Research Assistant TGR BioSciences
2004 - 2006 Medical Scientist Gribbles Pathology/Healthscope
2003 - 2004 Medical Scientist SA Health/Women's and Children's Hospital

Language Competencies

Language Competency
English Can read, write, speak, understand spoken and peer review
Greek, Modern (1453-) Can read, write, speak and understand spoken

Education

Date Institution name Country Title
2013 - 2016 The University of Adelaide Australia PhD
1999 - 2002 The University of South Australia Australia Bachelor of Medical and Pharmaceutical Biotechonolgy

Certifications

Date Title Institution name Country
Epigeum: Supervising Doctoral Studies The University of Adelaide

Keywords

Bone and Bones, Cancer Cell Biology, Cancer Therapy

Journals

Date Citation
2107 wang,Y, zinonos,I, zysk,A, Panagopoulos,V, Kaur,G, santos,A, losic,D, evdokiou,A, 2107, In vivo Toxicological Assessment of Electrochemically Engineered Anodic Alumina Nanotubes: A Study of Biodistribution, Subcutaneous Implantation and Intravenous Injection, Journal of Materials Chemistry B, 5, 13, 2511-2523 10.1039/C7TB00222J
2017 Leach,D, Panagopoulos,V, Nash,C, Bevan,C, Thomson,A, Selth,L, Buchanan,G, 2017, Cell-lineage specificity and role of AP-1 in the prostate fibroblast androgen receptor cistrome, Molecular and Cellular Endocrinology, 439, C, 261-272 10.1016/j.mce.2016.09.010
2017 Panagopoulos,V, Liapis,V, Zinonos,I, Hay,S, Leach,D, Ingman,W, DeNichilo,M, Atkins,G, Findlay,D, Zannettino,A et al, 2017, Peroxidase enzymes inhibit osteoclast differentiation and bone resorption, Molecular and Cellular Endocrinology, 440, C, 8-15 10.1016/j.mce.2016.11.007
2017 Zysk,A, DeNichilo,M, Panagopoulos,V, Zinonos,I, Liapis,V, Hay,S, Ingman,W, Ponomarev,V, Atkins,G, Findlay,D et al, 2017, Adoptive transfer of ex vivo expanded Vγ9Vδ2 T cells in combination with zoledronic acid inhibits cancer growth and limits osteolysis in a murine model of osteolytic breast cancer, Cancer Letters, 386, 141-150 10.1016/j.canlet.2016.11.013
2017 Panagopoulos,V, Leach,D, Zinonos,I, Ponomarev,V, Licari,G, Liapis,V, Ingman,W, Anderson,P, DeNichilo,M, Evdokiou,A et al, 2017, Inflammatory peroxidases promote breast cancer progression in mice via regulation of the tumour microenvironment, International Journal of Oncology, 50, 4, 1191-1200 10.3892/ijo.2017.3883
2016 DeNichilo,M, Shoubridge,A, Panagopoulos,V, Liapis,V, Zysk,A, Zinonos,I, Hay,S, Atkins,G, Findlay,D, Evdokiou,A et al, 2016, Peroxidase enzymes regulate collagen biosynthesis and matrix mineralization by cultured human osteoblasts, Calcified Tissue International, 98, 3, 294-305 10.1007/s00223-015-0090-6
2016 Liapis,V, Zinonos,I, Labrinidis,A, Hay,S, Ponomarev,V, Panagopoulos,V, Zysk,A, DeNichilo,M, Ingman,W, Atkins,G et al, 2016, Anticancer efficacy of the hypoxia-activated prodrug evofosfamide (TH-302) in osteolytic breast cancer murine models, Cancer Medicine, 5, 3, 534-545 10.1002/cam4.599
2015 DeNichilo,M, Panagopoulos,V, Rayner,T, Borowicz,R, Greenwood,J, Evdokiou,A, 2015, Peroxidase enzymes regulate collagen extracellular matrix biosynthesis, American Journal of Pathology, 185, 5, 1372-1384 10.1016/j.ajpath.2015.01.013
2015 Liapis,V, Labrinidis,A, Zinonos,I, Hay,S, Ponomarev,V, Panagopoulos,V, DeNichilo,M, Ingman,W, Atkins,G, Findlay,D et al, 2015, Hypoxia-activated pro-drug TH-302 exhibits potent tumor suppressive activity and cooperates with chemotherapy against osteosarcoma, Cancer Letters, 357, 1, 160-169 10.1016/j.canlet.2014.11.020
2015 Panagopoulos,V, Zinonos,I, Leach,D, Hay,S, Liapis,V, Zysk,A, Ingman,W, DeNichilo,M, Evdokiou,A, 2015, Uncovering a new role for peroxidase enzymes as drivers of angiogenesis, The International Journal of Biochemistry and Cell Biology, 68, 128-138 10.1016/j.biocel.2015.09.006
2014 Zinonos,I, Labrinidis,A, Liapis,V, Hay,S, Panagopoulos,V, Denichilo,M, Ponomarev,V, Ingman,W, Atkins,G, Findlay,D et al, 2014, Doxorubicin overcomes resistance to drozitumab by antagonizing inhibitor of apoptosis proteins (IAPS), Anticancer Research, 34, 12, 7007-7020
2014 Zinonos,I, Luo,K, Labrinidis,A, Liapis,V, Hay,S, Panagopoulos,V, Denichilo,M, Ko,C, Yue,G, Lau,C et al, 2014, Pharmacologic inhibition of bone resorption prevents cancer-induced osteolysis but enhances soft tissue metastasis in a mouse model of osteolytic breast cancer, International Journal of Oncology, 45, 2, 532-540 10.3892/ijo.2014.2468
2008 Borowicz,RA, Panagopoulos,V, Greenwood,JE, DeNichilo,MO, Rayner,TE, 2008, Discovery of a novel modulator of extracellular matrix with the potential to promote wound healing, WOUND REPAIR AND REGENERATION, 16, 2, A42-A42

Conference Papers

Date Citation
2015 Panagopoulos,V, Zinonos,I, Liapis,V, Hay,S, Ingman,W, Iasiello,MP, DeNichilo,MO, Evdokiou,A, 2015, Uncovering a new role for peroxidases in breast cancer development and metastasis

Teaching Interests:

2013-2016                   Mentored 1 Honours student and 3 PhD students

2013-2014                   Supervised a University of Adelaide summer student

2017 – present            Currently, co-supervising 2 PhD students and 1 Honours student.

Committee Memberships

Date Role Committee Institution Country
2017 Member Australian Society for Medical Research (ASMR) State Committee
2017 Representative BHI Strategic Research Directions Group Basil Hetzel Institute Australia
2015 - 2016 Representative BHI Management Committee Basil Hetzel Insitute
Org Unit
Surgical Specialties

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